Results 31 to 40 of about 1,083,054 (280)

Environmental temperature and choline requirement in rats. I: Choline deficiency in rats at various temperatures

Journal of Lipid Research, 1966
Rats were maintained at 2°, 21°, and 33° for 3 weeks on a choline-supplemented or a choline-deficient diet. In contrast to the findings of some other workers, choline deficiency produced fatty livers at all temperatures.The ratio of the total liver lipid
J.S. Chahl, C.C. Kratzing
doaj   +1 more source

Diurnal changes in liver and plasma lipids of choline-deficient rats

Journal of Lipid Research, 1966
Early effects of choline deficiency were studied in rats. Nonphospholipid (“neutral lipid”) and phospholipid were measured in plasma and in three fractions of a liver homogenate:sediment, supernatant fraction, and “floating fat.”A single choline ...
Bruno Rosenfeld, Jessie M. Lang
doaj   +1 more source

Novel insight on the impact of choline-deficiency in sepsis

Annals of Research Hospitals, 2019
Choline, an essential dietary component, is a selective α7 nicotinic acetylcholine (ACh) receptor agonist. It plays an important role in various metabolic and non-metabolic pathways including inflammatory pathways. Systemic inflammatory response syndrome
Ahmed W. Al-Humadi, Hussam W. Al-Humadi, C. Liapi   +2 more
semanticscholar   +1 more source

Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones

Mutation research, 2011
Steven H. Zeisel
openalex   +3 more sources

Serial plasma choline measurements after cardiac arrest in patients undergoing mild therapeutic hypothermia: a prospective observational pilot trial. [PDF]

PLoS ONE, 2013
OBJECTIVE: Choline is related to phospholipid metabolism and is a marker for global ischaemia with a small reference range in healthy volunteers. The aim of our study was to characterize the early kinetics of plasma free choline in patients after cardiac
Christian Storm, Oliver Danne, Per Magne Ueland, Christoph Leithner, Dietrich Hasper, Tim Schroeder   +5 more
doaj   +1 more source

Effects of dietary lipid level and environmental temperature on lipid metabolism in the intestine and liver, and choline requirement in Atlantic salmon (Salmo salar L) parr

Journal of Nutritional Science, 2023
Choline was recently established as an essential nutrient for Atlantic salmon at all life stages. Choline deficiency is manifested as an excessive accumulation of dietary fat within the intestinal enterocytes, a condition known as steatosis.
Daphne Siciliani, Trond M. Kortner, Gerd M. Berge, Anne Kristine Hansen, Åshild Krogdahl   +4 more
doaj   +1 more source

The Lysophospholipase PNPLA7 Controls Hepatic Choline and Methionine Metabolism

Biomolecules, 2023
The in vivo roles of lysophospholipase, which cleaves a fatty acyl ester of lysophospholipid, remained unclear. Recently, we have unraveled a previously unrecognized physiological role of the lysophospholipase PNPLA7, a member of the Ca2+-independent ...
Sayaka Harada, Yoshitaka Taketomi, Toshiki Aiba, Mai Kawaguchi, Tetsuya Hirabayashi, Baasanjav Uranbileg, Makoto Kurano, Yutaka Yatomi, Makoto Murakami   +8 more
doaj   +1 more source

Dietary Choline Mitigates High-Fat Diet-Impaired Chylomicrons Assembly via UPRer Modulated by perk DNA Methylation

Cells, 2022
High-fat diets (HFD) lead to impairment of chylomicrons (CMs) assembly and adversely influence intestinal lipid homeostasis. However, the mechanisms of HFD impairing CMs assembly have yet to be fully understood. Additionally, although choline, as a lipid-
Zhen-Yu Bai, Hua Zheng, Zhi Luo, Christer Hogstrand, Ling-Jiao Wang, Yu-Feng Song   +5 more
doaj   +1 more source

Identification and functional analysis of choline transporter in tongue cancer: A novel molecular target for tongue cancer therapy

Journal of Pharmacological Sciences, 2016
We examined the functional characteristics of choline uptake in human tongue carcinoma using the cell line HSC-3. Furthermore, we explored the possible correlation between the inhibition of choline uptake and apoptotic cell death.
Ryohta Nishiyama, Fumiaki Nagashima, Beniko Iwao, Yuiko Kawai, Kana Inoue, Arisa Midori, Tsuyoshi Yamanaka, Hiroyuki Uchino, Masato Inazu   +8 more
doaj   +1 more source

¹H-NMR-Based Metabonomics Study to Reveal the Progressive Metabolism Regulation of SAP Deficiency on ApoE^−/− Mice

Metabolites, 2022
Atherosclerosis is the most common disease of the vascular system and the metabolic disorder is one of its important molecular mechanisms. SAP protein is found to be highly expressed in atherosclerotic blood vessels.
Qian Li, Wanting Chen, Wenbin Huang, Ranran Hou, Xinping Huang, Man Xu, Limei Que, Lijing Wang, Yongxia Yang   +8 more
doaj   +1 more source