Results 91 to 100 of about 285,894 (338)
Pro-cognitive drug effects modulate functional brain network organization
Frontiers in Behavioral Neuroscience, 2012 Previous studies document that cholinergic and noradrenergic drugs improve attention, memory and cognitive control in healthy subjects and patients with neuropsychiatric disorders.
Carsten eGiessing, Christiane M Thiel
doaj +1 more source
Alzheimer’s Disease, Hearing Loss, and Deviance Detection
Frontiers in Neuroscience, 2022 Age-related hearing loss is a widespread condition among the elderly, affecting communication and social participation. Given its high incidence, it is not unusual that individuals suffering from age-related hearing loss also suffer from other age ...
David Pérez-González +9 more
doaj +1 more source
Cholinergic modulation of striatal microcircuits
European Journal of Neuroscience, 2018 The purpose of this review is to bridge the gap between earlier literature on striatal cholinergic interneurons and mechanisms of microcircuit interaction demonstrated with the use of newly available tools.
Nilupaer Abudukeyoumu +3 more
semanticscholar +1 more source
Determination of transmitter function by neuronal activity [PDF]
, 1977 The role of neuronal activity in the determination of transmitter function was studied in cultures of dissociated sympathetic neurons from newborn rat superior cervical ganglia.
Campenot, Robert B. +2 more
core
The nicotinic receptor of cochlear hair cells: A possible pharmacotherapeutic target? [PDF]
, 2009 Mechanosensory hair cells of the organ of Corti transmit information regarding sound to the central nervous system by way of peripheral afferent neurons.
Elgoyhen, Ana Belen +2 more
core +1 more source
Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches.
Cansu Öztürk +3 more
wiley +1 more source
Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics
Proteins: Structure, Function, and Bioinformatics, EarlyView., 2023 Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar +2 more
wiley +1 more source
Experimental Pharmacology in Transgenic Rodent Models of Alzheimer’s Disease
Frontiers in Pharmacology, 2019 This Mini Review discusses the merits and shortfalls of transgenic (tg) rodents modeling aspects of the human Alzheimer’s disease (AD) pathology and their application to evaluate experimental therapeutics.
A. Claudio Cuello +4 more
doaj +1 more source
Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice
Brain Sciences, 2020 Background: Parkinsonism is caused by dopamine (DA) insufficiency and results in a hypokinetic movement disorder. Treatment with L-Dopa can restore DA availability and improve motor function, but patients can develop L-Dopa-induced dyskinesia (LID), a ...
Ziqing Shi +5 more
doaj +1 more source
Acta Pharmacologica Sinica, 2019 Midbrain dopaminergic (DA) neurons are governed by an endogenous cholinergic system, originated in the mesopontine nuclei. Nicotine hijacks nicotinic acetylcholine receptors (nAChRs) and interferes with physiological function of the cholinergic system ...
C. Xiao +3 more
semanticscholar +1 more source