Results 81 to 90 of about 195,821 (248)

The Binding and Effects of Boron-Containing Compounds on G Protein-Coupled Receptors: A Scoping Review

Receptors
Boron-containing compounds (BCCs) have emerged as potential drugs. Their drug-like effects are mainly explained by their mechanisms of action in enzymes.
José M. Santiago-Quintana, Alina Barquet-Nieto, Bhaskar C. Das, Rafael Barrientos-López, Melvin N. Rosalez, Ruth M. Lopez-Mayorga, Marvin A. Soriano-Ursúa   +6 more
doaj   +1 more source

Quantification of Palmar and Digital Epidermal Thickness and Sweat Duct Density

Clinical Anatomy, EarlyView.
ABSTRACT Palmar digital skin, with its high density of epidermal sweat glands and unique stratum corneum, derives its autonomic innervation from peripheral nerves. Understanding the changes to these structures could serve as objective proxy markers following peripheral nerve injury and interventions to promote regeneration.
Elizabeth Jones, Hanaa N. Mughal, Roxana Moscalu, Malachy Columb, Christopher Duff, Mark Dickinson, Adam J. Reid, Ralph N. A. Murphy   +7 more
wiley   +1 more source

Association of cholinergic biomarkers with postoperative delirium in elderly patients undergoing regional anesthesia - An observational study

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Postoperative delirium (POD) is a prevalent and serious complication in elderly patients undergoing surgery, contributing to prolonged hospital stays and increased morbidity.
Praveen Kumar Yadav, Shefali Gautam, Jyotsna Agrawal, Neel Kamal Mishra, Vinod Kumar Srivastava, Shashank Kanaujia, Rajesh Raman, Mohammad Kaleem Ahmad   +7 more
doaj   +1 more source

Efficacy of Lecaniodiscus cupanioide and Alchornea cordifolia supplemented diets on neurotransmitter, neuroinflammatory, and antioxidant systems of scopolamine-induced amnesia in rat hippocampus [PDF]

Exploration of Neuroscience
Aim: Natural products possess diverse pharmacological properties that are effective and safe for treating and managing amnesia; however, there is little or no scientific proof for most of their claims.
Odunayo Michael Agunloye, Ayodele Ebenezer Aijo, Olamide Wilson Fasakin, Ganiyu Oboh   +3 more
doaj   +1 more source

Opsoclonus in Pediatric Patients: Differential Diagnosis and a Practical Approach to Evaluation

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Opsoclonus is an ocular dyskinesia characterized by involuntary, arrhythmic, multidirectional saccades. In pediatrics, opsoclonus is most commonly attributed to the rare neuroinflammatory disorder opsoclonus‐myoclonus‐ataxia syndrome (OMAS), typically considered a paraneoplastic syndrome associated with neural crest tumors. However, opsoclonus
Aubrey C. Reed, Supreet S. Randhawa, Jason H. Peragallo, Prabhumallikarjun Patil, Grace Gombolay, Varun Kannan   +5 more
wiley   +1 more source

Examination of cortically-projecting cholinergic neurons following exercise and environmental intervention in a rodent model of Fetal Alcohol Spectrum Disorders (FASD)

, 2023
Klintsova, Anna Y.Background: 1 in 20 live births in the United States is exposed to alcohol prenatally, resulting in neurodevelopmental and behavioral deficits categorized under the umbrella clinical term, Fetal Alcohol Spectrum Disorders (FASD ...
Milbocker, Katrina A.
core   +1 more source

Anterior cingulate cortex neuron subtypes differentially regulate seizures

Epilepsia, EarlyView.
Abstract Objective This study aimed to investigate the regulatory roles of distinct neuronal subtypes within the anterior cingulate cortex (ACC) in acute seizures and to identify cell type‐specific mechanisms underlying seizure modulation in this region. Methods Acute seizure models were established in mice via pentylenetetrazol injection.
Ziqian Yan, Ting Tang, Kaishan Wang, Bin Fu, Zesheng Li, Mingshan Liu, Hongyi Huang, Yanfeng Yang, Qiang Zheng, Yangmin Zheng, Yongzhi Shan, Yumin Luo, Guoguang Zhao   +12 more
wiley   +1 more source

Striatal dual cholinergic /GABAergic transmission in Parkinson disease: friends or foes? [PDF]

, 2018
The rule of one terminal and one transmitter acting on one synapse clearly fails to cover the complexity of chemical synapse operation in the brain. Compelling evidence now indicates that two transmitters can be released from the same terminal, acting in
Constance Hammond, Natalia Lozovaya, Yehezkel Ben-Ari   +2 more
core   +1 more source

3D Reconstruction of the Neurovascular Unit Reveals Differential Loss of Cholinergic Innervation in the Cortex and Hippocampus of the Adult Mouse Brain

Frontiers in Aging Neuroscience, 2019
Increasing evidence supports a role for cerebrovasculature dysfunction in the etiology of Alzheimer’s disease (AD). Blood vessels in the brain are composed of a collection of cells and acellular material that comprise the neurovascular unit (NVU).
Shereen Nizari, Roxana O. Carare, Ignacio A. Romero, Cheryl A. Hawkes   +3 more
doaj   +1 more source

Nucleus basalis functional connectivity aberrations in temporal lobe epilepsy and improvements after successful epilepsy surgery

Epilepsia, EarlyView.
Abstract Objective Resective surgery achieves seizure freedom in approximately 60%–80% of patients with drug‐resistant temporal lobe epilepsy (TLE), yet the extent to which seizure cessation permits recovery of disrupted functional brain networks remains unclear.
Addison C. Cavender, Derek J. Doss, Ghassan S. Makhoul, Bruno Hidalgo Monroy Lerma, Anas Reda, C. Price Withers, Emily Liao, Kate Wang, Hernán F. J. González, Sarah E. Goodale, Graham W. Johnson, Laurie E. Cutting, Sarah K. Bick, Catie Chang, Victoria L. Morgan, Dario J. Englot   +15 more
wiley   +1 more source