Results 71 to 80 of about 146,455 (266)

The Cholinergic Gene Locus [PDF]

Journal of Neurochemistry, 1998
Abstract: Messenger RNAs and the cognate gene(s) encoding choline acetyltransferase (ChAT) and the vesicular acetylcholine transporter (VAChT) have been cloned from mammals and several other animal classes in the last decade. These have provided molecular tools for investigating acetylcholine synthesis and packaging into synaptic vesicles, the genesis ...
openaire   +2 more sources

Dopaminergic novelty detection and theta oscillations: Virtual reality‐based adaptive interventions for cognitive enhancement in aging

Ibrain, EarlyView.
Aging‐related cognitive decline is associated with reduced dopaminergic signaling and disrupted theta oscillations, which together impair novelty detection and memory formation. This review shows how VR environments can be used to deliver adaptive, novelty‐rich stimuli that engage dopaminergic circuits and entrain theta rhythms, thereby enhancing ...
Abraham Olufemi Asuku, Ayodeji Johnson Ajibare   +1 more
wiley   +1 more source

Role of cholinergic innervation and RGS2 in atrial arrhythmia

Frontiers in Physiology, 2012
The heart receives both sympathetic and parasympathetic efferent innervation as well as having the ability to process information internally via an intrinsic cardiac autonomic nervous system (ICANS).
DOUGLAS L. JONES, Jari Micheal Tuomi, Peter eChidiac   +2 more
doaj   +1 more source

Cognition in menopausal women

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Cognitive health in postmenopausal women is significantly affected by hormonal shifts, especially the drop in estrogen levels. This review explores the intricate relationship between menopause and cognitive functions across six domains: perception, attention, memory, language, executive functioning, and motor skills.
Suvarna Khadilkar, Jharna Mahajan (Bhanushali), Anuradha P. Mahto, Satish Khadilkar   +3 more
wiley   +1 more source

A brief review on the mode of action of antinematodal drugs

Acta Veterinaria, 2017
Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites.
Abongwa Melanie, Martin Richard J., Robertson Alan P.   +2 more
doaj   +1 more source

White Matter Dysfunction and Neurotransmitter Basis Underlying the Freezing of Gait in Parkinson's Disease

iNew Medicine, Volume 2, Issue 2, June 2026.
In the freezing of gait in Parkinson's disease, white matter shows decreased local activity but increased functional connectivity. These distinct dysfunctions are uniquely associated with specific neurotransmitter systems (GABA, dopamine, etc.), mapping a new neurochemical basis for this debilitating symptom. ABSTRACT Freezing of gait (FOG) is a severe
Pingping Liu, Jinmei Sun, Lili Hu, Xin Chen, Jinying Han, Liuzhenxiong Yu, Siyu Fan, Rong Ye, Kai Wang, Gong‐Jun Ji, Panpan Hu   +10 more
wiley   +1 more source

Postnatal - Physiological Research of the Bronchial Receptor System Development on the Isolated Preparation of The Human Trachea In Vitro

Biomolecules & Biomedicine, 2006
Research was done on pharmacological-physiological development of the bronchial receptor system on the smooth muscles of trachea in the newborn children, alive-born and stillborn children.
Aziz Šukalo, Hilmi Islami, Ragib Shabani, Hilmi Dauti, Skender Kutllovci, Bashkim Kastrati   +5 more
doaj   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

A cell autonomous torsinA requirement for cholinergic neuron survival and motor control

eLife, 2018
Cholinergic dysfunction is strongly implicated in dystonia pathophysiology. Previously (Pappas et al., 2015;4:e08352), we reported that Dlx5/6-Cre mediated forebrain deletion of the DYT1 dystonia protein torsinA (Dlx-CKO) causes abnormal twisting and ...
Samuel S Pappas, Jay Li, Tessa M LeWitt, Jeong-Ki Kim, Umrao R Monani, William T Dauer   +5 more
doaj   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source