Results 111 to 120 of about 345,248 (352)

Cholinergic stimulation stabilizes TRPM4 in the plasma membrane of cortical pyramidal neurons

Frontiers in Cell and Developmental Biology
TRPM4 is a calcium activated non-selective cation channel, impermeable to Ca2+, in neurons it has been implicated in the regulation of the excitability and in the persistent firing.
Paula Leyton, Denise Riquelme, Francisco A. Peralta, Franco D. Navarro, Elias Leiva-Salcedo   +4 more
doaj   +1 more source

Cholinergic innervation is necessary to shift reward timing activity in rodent visual cortex [PDF]

, 2011
While the biological analogue of prediction error has been well characterized in the midbrain dopaminergic system, the possibility of other neuromodulatory systems acting as global reinforcers is a topic of much debate.
Emma Roach, Marshall Hussain Shuler
core   +2 more sources

Molecular, Cellular and Circuit Basis of Cholinergic Modulation of Pain

Neuroscience, 2017
Highlights • Cholinergic mechanisms modulate multiple stations of the pain pathway.• Cholinomimetic drugs may provide a promising avenue in pain therapy.• Bilateral cholinergic–opioidergic interactions are therapeutically important.• Underlying circuits ...
Paul V. Naser, R. Kuner
semanticscholar   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

The Binding and Effects of Boron-Containing Compounds on G Protein-Coupled Receptors: A Scoping Review

Receptors
Boron-containing compounds (BCCs) have emerged as potential drugs. Their drug-like effects are mainly explained by their mechanisms of action in enzymes.
José M. Santiago-Quintana, Alina Barquet-Nieto, Bhaskar C. Das, Rafael Barrientos-López, Melvin N. Rosalez, Ruth M. Lopez-Mayorga, Marvin A. Soriano-Ursúa   +6 more
doaj   +1 more source

Cooperative Glutamatergic and Cholinergic Mechanisms Generate Short-Term Modifications of Synaptic Effectiveness in Prepositus Hypoglossi Neurons [PDF]

, 2005
To maintain horizontal eye position on a visual target after a saccade, extraocular motoneurons need a persistent (tonic) neural activity, called "eye-position signal," generated by prepositus hypoglossi (PH) neurons.
Delgado-Garcia, JM, Navarro Lopez, JDD, Yajeya, J   +2 more
core   +1 more source

GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease

Nature Communications, 2018
We report that half striatal cholinergic interneurons are dual transmitter cholinergic and GABAergic interneurons (CGINs) expressing ChAT, GAD65, Lhx7, and Lhx6 mRNAs, labeled with GAD and VGAT, generating monosynaptic dual cholinergic/GABAergic currents
N. Lozovaya, Sanaz Eftekhari, R. Cloarec, Laurie-Anne Gouty-Colomer, Amandine Dufour, B. Riffault, M. Billon-Grand, Alexandre Pons-Bennaceur, N. Oumar, N. Burnashev, Y. Ben-Ari, C. Hammond   +11 more
semanticscholar   +1 more source

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

Association of cholinergic biomarkers with postoperative delirium in elderly patients undergoing regional anesthesia - An observational study

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Postoperative delirium (POD) is a prevalent and serious complication in elderly patients undergoing surgery, contributing to prolonged hospital stays and increased morbidity.
Praveen Kumar Yadav, Shefali Gautam, Jyotsna Agrawal, Neel Kamal Mishra, Vinod Kumar Srivastava, Shashank Kanaujia, Rajesh Raman, Mohammad Kaleem Ahmad   +7 more
doaj   +1 more source

Synergistic Enhancement: Whole Wheat Substrate Improves Memory in Mice by Optimizing Folate Metabolism and Systemic Antioxidant Capacity

Food Bioengineering, EarlyView.
ABSTRACT This study rigorously assessed the impact of folic acid‐fortified whole wheat products on mitigating mild liver injury caused by prolonged excessive folic acid consumption, improving folic acid bioavailability, and enhancing spatial cognitive functions in mice over a 48‐day intervention period.
Yan Qi, Songyi Lin, Meina Zhang, Yue Tang   +3 more
wiley   +1 more source