Results 111 to 120 of about 285,894 (338)

Evidence that cholinergic mechanisms contribute to hyperexcitability at early stages in Alzheimer’s disease

Frontiers in Dementia
A long-standing theory for Alzheimer’s disease (AD) has been that deterioration of synapses and depressed neuronal activity is a major contributing factor.
Helen E. Scharfman, Helen E. Scharfman, Helen E. Scharfman, Helen E. Scharfman, Helen E. Scharfman, Korey Kam, Áine M. Duffy, John J. LaFrancois, Paige Leary, Elissavet Chartampila, Stephen D. Ginsberg, Stephen D. Ginsberg, Stephen D. Ginsberg, Stephen D. Ginsberg, Christos Panagiotis Lisgaras, Christos Panagiotis Lisgaras   +15 more
doaj   +1 more source

Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement

eLife, 2019
Interplay between dopaminergic and cholinergic neuromodulation in the striatum is crucial for movement control, with prominent models proposing pro-kinetic and anti-kinetic effects of dopamine and acetylcholine release, respectively. However, the natural,
Mark Howe, Imane Ridouh, A. L. Allegra Mascaro, A. Larios, Maite Azcorra, D. Dombeck   +5 more
semanticscholar   +1 more source

Quantification of Palmar and Digital Epidermal Thickness and Sweat Duct Density

Clinical Anatomy, EarlyView.
ABSTRACT Palmar digital skin, with its high density of epidermal sweat glands and unique stratum corneum, derives its autonomic innervation from peripheral nerves. Understanding the changes to these structures could serve as objective proxy markers following peripheral nerve injury and interventions to promote regeneration.
Elizabeth Jones, Hanaa N. Mughal, Roxana Moscalu, Malachy Columb, Christopher Duff, Mark Dickinson, Adam J. Reid, Ralph N. A. Murphy   +7 more
wiley   +1 more source

The Role of microRNA in Overactive Bladder: Relationship and Clinical Correlation

Medicina
Background and Objectives: This study aimed to determine the relationship between miRNAs and overactive bladder (OAB). We also aimed to reveal the diagnostic properties of miRNAs and their potential to predict responses to therapy. Materials and Methods:
Kürşat Küçüker, Hülya Aybek, Hakan Akça, Ege Rıza Karagür, Elif Fırat, Yusuf Özlülerden, Sinan Çelen, Zafer Aybek   +7 more
doaj   +1 more source

New Insights Into Cholinergic Neuron Diversity

Frontiers in Molecular Neuroscience, 2019
Cholinergic neurons comprise a small population of cells in the striatum but have fundamental roles in fine tuning brain function, and in the etiology of neurological and psychiatric disorders such as Parkinson’s disease (PD) or schizophrenia.
N. Y. Ahmed, R. Knowles, N. Dehorter
semanticscholar   +1 more source

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent [PDF]

, 2018
Objective: To determine if human colonic neuromuscular functions decline with increasing age.Design: Looking for non-specific changes in neuromuscular function, a standard burst of electrical field stimulation (EFS) was used to evoke neuronally mediated (
Ahmed, Shafi, Broad, John, Carroll, Rebecca, Chin-Aleong, Joanne, Darreh-Shori, Taher, Elahi, Shezan, Karami, Azadeh, Knowles, Charles H., Kung, Victor W. S., Martin, Joanne E., Palmer, Alexandra, Saffrey, M. Jill, Sanger, Gareth John, Thaha, Mohamed Adhnan   +13 more
core   +2 more sources

Periodontitis presenting among betel quid users: A case series

Clinical Advances in Periodontics, EarlyView.
Abstract Background Betel leaf chewing habit has been studied extensively, as it has been an ancient practice in many Asian countries. Although betel leaf has been reported to have potential beneficial properties, it has also been shown to have a strong association with oral diseases, including periodontitis. This case series addresses the presentation
Jungweon V. Park, Priyanka K. Pitchumani, Dimitris N. Tatakis   +2 more
wiley   +1 more source

Cholinergic, Glutamatergic, and GABAergic Neurons of the Pedunculopontine Tegmental Nucleus Have Distinct Effects on Sleep/Wake Behavior in Mice

Journal of Neuroscience, 2017
The pedunculopontine tegmental (PPT) nucleus has long been implicated in the regulation of cortical activity and behavioral states, including rapid eye-movement (REM) sleep.
D. Kroeger, L. Ferrari, Gaetan Petit, C. E. Mahoney, P. Fuller, E. Arrigoni, T. Scammell   +6 more
semanticscholar   +1 more source

Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]

, 2016
Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
core   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source