Results 121 to 130 of about 169,479 (311)
Distribution of Cholinergic and Catecholaminergic Nerves in the Colon of the Rat with Aganglionosis
Tatsuo Gonda, Mitsuru Oki
openalex +2 more sources
Abstract Botulism is a severe and often fatal disease in equine patients worldwide. Clostridium botulinum is a ubiquitous soil organism which produces a potent neurotoxin resulting in neuromuscular blockade and flaccid paralysis in affected animals. Definitive diagnosis is often impractical or impossible, leading to diagnosis and treatment based on ...
Kali Slavik +2 more
wiley +1 more source
Aleksandar R Zivkovic, Jochen Bender, Thorsten Brenner, Stefan Hofer,* Karsten Schmidt* Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany *These authors contributed equally to this work Purpose: Early diagnosis of ...
Zivkovic AR +4 more
doaj
TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir +7 more
wiley +1 more source
The effects of Nicotine on licking behavior induced by Apomorphine in rats
Objective: The purpose of the present study was to determine the possible interaction of nicotine or muscarinic receptor mechanism(s) with the licking behavior induced by apomorphine in rats.
MR Zarrindast, M Shecharchi, M Rezayat
doaj
Progress in cholinergic biology: Model cholinergic synapses [PDF]
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Activation of dopamine receptor D1 (D1R) stimulates PKA and ERK pathways via dissociation of stimulatory and olfactory G protein alpha subunits (Gαs/olf). PKA relieves striatal‐enriched protein tyrosine phosphatase (STEP) inhibition of ERK, promoting cyclic adenosine monophosphate response element‐binding protein (CREB)‐driven transcription of ...
Kevin Chua +2 more
wiley +1 more source
A role for the cholinergic neuron circadian clock in RNA metabolism and mediating neurodegeneration. [PDF]
Tam SB +7 more
europepmc +1 more source
Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari +6 more
wiley +1 more source

