Results 151 to 160 of about 285,894 (338)
International Journal of Cancer, EarlyView.What's New? The rarity of acute lymphoblastic leukaemia and lack of available environmental data have made the role of environmental factors in genetic subtypes challenging to investigate. Here, the authors performed a CpG‐level analysis to investigate DNA methylation as an intermediate mechanism between environmental risk exposures and acute ...
Jessica R. Saville +5 more
wiley +1 more source
Neuropsychiatric symptoms in siblings of children with Tourette syndrome in the EMTICS study
JCPP Advances, EarlyView.This multicenter study demonstrated that siblings of children with higher YGTSS score showed a higher level of ASD symptoms. We further report that only female siblings of children with high tic symptom severity showed higher inattention and ODD symptoms.
Olga Sidiropoulou +8 more
wiley +1 more source
JEADV Clinical Practice, EarlyView.This retrospective observational study analyzed a cohort of chronic urticaria (CU) patients to provide insight into the clinical practice of CU with second‐generation antihistamines (SgAHs) and to evaluate the long‐term real‐world effectiveness of rupatadine in CU. Patients with chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU)
A. M. Giménez‐Arnau +5 more
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Restless Legs Syndrome (RLS) is a neurological disorder reported to be associated with impulsivity and impairments in interoception and emotional regulation. However, limited research has explored the combined influence of RLS severity, psychological factors, and chronotype on impulsive decision‐making and risk‐taking behavior in ...
Giacomo Carollo +5 more
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Non‐motor fluctuations, characterized by variability in mood and cognition, are prevalent in advanced Parkinson's disease (PD), but less is known about these fluctuations in early PD. Objective The objective was to characterize fluctuations in cognition and mood in early PD without cognitive impairment.
Abhimanyu Mahajan +4 more
wiley +1 more source
A Dopamine-Acetylcholine Cascade: Simulating Learned and Lesion-Induced Behavior of Striatal Cholinergic Interneurons [PDF]
, 2007 The "teaching signal" that modulates reinforcement learning at cortico-striatal synapses may be a sequence composed of an adaptively scaled DA burst, a brief ACh burst, and a scaled ACh pause.
Bullock, Daniel, Tan, Can Ozan
core +1 more source
Myoclonic Dystonia: A Common Phenomenology in the Pleomorphic Movements of Angelman Syndrome
Movement Disorders Clinical Practice, EarlyView.Abstract Background Angelman syndrome (AS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, a sociable demeanor, and abnormal movements. People with AS often exhibit multiple types of abnormal movements, including nonepileptic myoclonus, tremor, and dystonia, which hamper attempts to identify phenomenology
Robert P. Carson +8 more
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background The coexistence of tics with Parkinson's disease (PD) is rare, as they often emerge at different ages, follow different trajectories and involve contrasting pathophysiological mechanisms related to dopamine availability and function in the brain. Cases We present 10 individuals with primary tic disorders who later developed PD.
Tarig Abkur +11 more
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Antiparkinson medications are effective in improving Parkinson's disease (PD) motor symptoms such as bradykinesia, tremor, and rigidity. The impact of antiparkinson medication on gait speed is less clear. Objectives The primary aim was to determine the effects of antiparkinson medication on gait speed in PD. The secondary aim was to
Anson B. Rosenfeldt +10 more
wiley +1 more source
Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease
Movement Disorders, EarlyView.Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou +6 more
wiley +1 more source