Results 161 to 170 of about 345,248 (352)

The cholinergic hypothesis of Alzheimer’s disease: a review of progress

open access: yesJournal of Neurology Neurosurgery & Psychiatry, 1999
P. Francis   +3 more
semanticscholar   +1 more source

Taxon, Arboreality, Sex, and Season—Factors Influencing Gastrointestinal Parasite Occurrence in Zoo‐Housed Non‐Human Primates

open access: yesZoo Biology, EarlyView.
ABSTRACT The emergence of anthelminthic resistance is a well‐documented phenomenon in livestock and companion animals. Given the scarcity of new antiparasitic drugs, the implementation of effective, holistic anthelminthic control strategies is critical to preserving the efficacy of existing treatments.
Stalder Sandro, Hatt Jean‐Michel
wiley   +1 more source

Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors

open access: yesActa Crystallographica Section F, EarlyView.
The crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Masashi Mima   +4 more
wiley   +1 more source

Bidirectional genetic and phenotypic links between smoking and striatal iron content involving dopaminergic and inflammatory pathways

open access: yesAddiction, EarlyView.
Abstract Background and aims Tobacco smoking is a major risk factor for cardiovascular and lung diseases. A better understanding of its neurobiological underpinnings will benefit the prevention of smoking‐related illnesses and mortality. Previous studies link smoking to increased iron concentration in the striatum, a central component of the brain's ...
Olga Trofimova   +2 more
wiley   +1 more source

Hippocampal subfield differences in people with and without recreational ketamine use: Insights from multi‐modal neuroimaging

open access: yesAddiction, EarlyView.
Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu   +8 more
wiley   +1 more source

Reduced butyrylcholinesterase activity is an early indicator of trauma-induced acute systemic inflammatory response

open access: yesJournal of Inflammation Research, 2016
Aleksandar R Zivkovic, Jochen Bender, Thorsten Brenner, Stefan Hofer,* Karsten Schmidt* Department of Anesthesiology, Heidelberg University Hospital, Heidelberg, Germany *These authors contributed equally to this work Purpose: Early diagnosis of ...
Zivkovic AR   +4 more
doaj  

The International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria

open access: yesAllergy, EarlyView.
ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
T. Zuberbier   +221 more
wiley   +1 more source

The effects of Nicotine on licking behavior induced by Apomorphine in rats

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 1999
Objective: The purpose of the present study was to determine the possible interaction of nicotine or muscarinic receptor mechanism(s) with the licking behavior induced by apomorphine in rats.
MR Zarrindast, M Shecharchi, M Rezayat
doaj  

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