Results 161 to 170 of about 285,894 (338)

The increased effective connectivity from left middle occipital gyrus to right medial septum/diagonal bands in AD patients after donepezil intervention

Frontiers in Aging Neuroscience
IntroductionDonepezil enhances the function of cholinergic nerves by increasing the concentration of acetylcholine, thereby improving clinical symptoms in patients with Alzheimer’s disease (AD).
Ting Yang, Fuquan Wei, Yufei Guo, Mengxiao Zhu, Hongtao Hou, Zhongwei Guo, Xiaozheng Liu, Xiaozheng Liu   +7 more
doaj   +1 more source

Pathophysiological Role of Primary Motor Cortex in Essential Tremor

Movement Disorders, EarlyView.
Abstract Background Essential tremor (ET) is one of the most prevalent movement disorders. However, the complete understanding of ET pathophysiology remains elusive. Objective To explore the pathophysiological role of primary motor cortex (M1) in ET, specifically exploring its neurophysiological changes and their correlation with voluntary motor ...
Daniele Birreci, Luca Angelini, Giulia Paparella, Davide Costa, Antonio Cannavacciuolo, Massimiliano Passaretti, Martina De Riggi, Simone Aloisio, Donato Colella, Andrea Guerra, Matteo Bologna   +10 more
wiley   +1 more source

Cholinergic stimulation stabilizes TRPM4 in the plasma membrane of cortical pyramidal neurons

Frontiers in Cell and Developmental Biology
TRPM4 is a calcium activated non-selective cation channel, impermeable to Ca2+, in neurons it has been implicated in the regulation of the excitability and in the persistent firing.
Paula Leyton, Denise Riquelme, Francisco A. Peralta, Franco D. Navarro, Elias Leiva-Salcedo   +4 more
doaj   +1 more source

Distinct Longitudinal Clinical‐Neuroanatomical Trajectories in Parkinson's Disease Clinical Subtypes: Insight toward Precision Medicine

Movement Disorders, EarlyView.
ABSTRACT Background Parkinson's disease (PD) varies widely across individuals in clinical manifestations and course of progression. Identification of distinct biological subtypes could explain this heterogeneity, identify its pathophysiology, and predict disease progression. Objectives Our aim was to compare longitudinal clinical trajectories and brain
Seyed‐Mohammad Fereshtehnejad, Roqaie Moqadam, Houman Azizi, Ronald B. Postuma, Mahsa Dadar, Anthony E. Lang, Connie Marras, Yashar Zeighami   +7 more
wiley   +1 more source

New Insights into the Development of Donepezil-Based Hybrid and Natural Molecules as Multi-Target Drug Agents for Alzheimer’s Disease Treatment

Molecules
Alzheimer’s disease (AD) involves a complex pathophysiology with multiple interconnected subpathologies, including protein aggregation, impaired neurotransmission, oxidative stress, and microglia-mediated neuroinflammation.
Violina T. Angelova, Boris P. Stoyanov, Rumyana Simeonova   +2 more
doaj   +1 more source

A Role for the Kolliker-Fuse Nucleus in Cholinergic Modulation of Breathing at Night During Wakefulness and NREM Sleep [PDF]

, 2010
For many years, acetylcholine has been known to contribute to the control of breathing and sleep. To probe further the contributions of cholinergic rostral pontine systems in control of breathing, we designed this study to test the hypothesis that ...
Bonis, Joshua M., Forster, Hubert V., Kiner, T., Krause, Katie L., Marshall, B. D., Neumueller, Suzanne E., Pan, Lawrence, Qian, B., Smith, A.   +8 more
core   +1 more source

Molecular Tools to Study and Control Dopaminergic Neurotransmission With Light

Medicinal Research Reviews, EarlyView.
ABSTRACT Dopaminergic neurotransmission is involved in several important brain functions, such as motor control, learning, reward‐motivated behavior, and emotions. Dysfunctions of dopaminergic system may lead to the development of various neurological and psychiatric disorders, like Parkinson's disease, schizophrenia, depression, and addictions ...
Galyna Maleeva, Carlo Matera, Silvia Roda, Alessio Colleoni, Marco De Amici, Pau Gorostiza   +5 more
wiley   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, EarlyView.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Xanomeline‐Trospium Chloride (Cobenfy): A New Era in Managing Schizophrenia—Comparative Effectiveness and Economic Challenges

Medicine Advances, EarlyView.
Xanomeline‐trospium chloride (cobenfy) is a muscarinic agonist used to treat hallucinations and psychotic illnesses such as Alzheimer's and Schizophrenia. It has been constructed for patients who are unable to tolerate dopamine‐targeting therapies and a comparison is drawn against other similar drugs with variables like cost, mechanism of action ...
Jawairya Muhammad Hussain, Wajiha Arif, Sharjeel Humayun, Nida Shoaib, Saim Mahmood Khan   +4 more
wiley   +1 more source

Acetylcholinesterase Inhibition and Antioxidant Activity of DHA‐Disubstituted Phospholipids

Molecular Nutrition &Food Research, EarlyView.
1,2‐Di‐DHA‐PC phospholipids in nutraceutical form may cross the blood‐brain barrier and inhibit acetylcholinesterase (AChE) activity, with an efficacy similar to galantamine. This suggests their potential as neuroprotective agents in the treatment of Alzheimer's disease.
Ernestina Garcia‐Quinto, Sabrina Sollecito‐Rovella, Victor M. Amador‐Luna, Lidia Montero, Gloria Fernandez‐Lorente   +4 more
wiley   +1 more source