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Cholinergic Activity of Hyoscyamine [PDF]
Nature, 1961 MANY former and recent investigations, employing various clinical and experimental tests1–4, have already revealed the synergic action of small atropine doses with acetylcholine. We were able to demonstrate quite an unexpected experimental correlation between hyoscyamine and cholinergic activity.
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Acetylcholine (ACh) is a leading regulatory neurotransmitter in the nervous system, which functions both directly and as modulator of other neurotransmitters. It is found in the central and peripheral nervous system, as well as in the autonomic system-both sympathetic and parasympathetic. In the central nervous system (CNS), ACh functions not only as a
Hermona, Soreq, Adi, Bar, Iddo, Paldor
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Hermona, Soreq, Adi, Bar, Iddo, Paldor
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Cholinergic Vasoconstriction in the Eye
Journal of Ocular Pharmacology and Therapeutics, 1990Data is presented to support a physiologic vasoconstrictor function of the parasympathetic nervous system in the anterior uvea of the eye. Studies in rabbits, cats and monkeys demonstrate that stimulation of the parasympathetic nerve fibers running with the oculomotor nerve to the eye induces a reduction in blood flow of the iris and in rabbits in the ...
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Cholinergic mechanisms in hydra
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1978Abstract 1. In the homogenate from hydra tissue an enzyme was demonstrated which hydrolyses acetylcholine and butyrylcholine. 2. By the usual criteria this enzyme does not belong to the cholinesterase group since its activity is not influenced by cholinesterase inhibitors except TEPP. 3.
Ida Eržen, Miro Brzin
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Are there cholinergic and non-cholinergic paradoxical sleep-on neurones in the pons?
NeuroReport, 1996Using microiontophoresis on unanesthetized head-restrained cats, we have found two distinct groups of neurones exhibiting tonic discharge specific to paradoxical sleep (PS) (PS-on neurones) in the mesopontine tegmentum, which contains both cholinergic and non-cholinergic neurones.
Kazuya Sakai, Yoshimasa Koyama
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Acetylcarnitine and Cholinergic Receptors
Journal of Pharmaceutical Sciences, 1980Acetylcarnitine, a naturally occurring compound found in high concentration in heart and skeletal muscle of vertebrates, bears structural resemblance to acetylcholine, and studies have shown that it has slight cholinergic properties. Acetylcarnitine was subjected to conformational analysis by extended Hückel theory (EHT) and complete neglect of ...
Wallace J. Murray +2 more
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Cholinergic Systems and Multiple Cholinergic Receptors in Ocular Tissues
Journal of Ocular Pharmacology and Therapeutics, 1985Acetylcholine (ACh), choline acetyltransferases and cholinesterases occur in cornea, iris-ciliary body complex and retina of several vertebrates. In cornea, ACh may serve as a sensory transmitter as well as a local hormone, the function of which is not delineated.
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1963
Publisher Summary This chapter describes neurohormones as pharmacologically active substances released by nerve cells. They act in three main ways. They may be released into the blood stream or into non-nervous tissues and act peripherally; they may influence the level of excitability of surrounding nerve cells, perhaps by affecting their metabolism ...
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Publisher Summary This chapter describes neurohormones as pharmacologically active substances released by nerve cells. They act in three main ways. They may be released into the blood stream or into non-nervous tissues and act peripherally; they may influence the level of excitability of surrounding nerve cells, perhaps by affecting their metabolism ...
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Pharmakologie cholinerger Synapsen [PDF]
, 1982 Acetylcholin CH3COO-CH2CH2N+(CH3)3 ist der primare BotenStoff im cholinergen System. Als synaptischer Transmitter wird Acetylcholin freigesetzt aus den prasynaptischen Terminalen von α- und γ-Motoneuronen, postganglionaren parasympathischen Neuronen, praganglionaren sympathischen und parasympathischen Neuronen, und aus Neuronen im ZNS.
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Cholinergic therapy in dementia
Acta Neurologica Scandinavica, 2009After reviewing the evidence for cholinergic pathology in Alzheimer's disease and related disorders, this paper reviews strategies for treating dementia using cholinomimetic drugs. Special attention is paid to cholinesterase inhibitors, particularly tacrine, the drug recently approved by the FDA.
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