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Cholinergic neuropharmacology: an update
Acta Psychiatrica Scandinavica, 1991The current status of the pharmacology of central cholinergic transmission is reviewed. Particular attention is paid to the compounds that have been or are potential candidates as therapeutic agents for the treatment of mental disorders, particularly senile dementia. Compounds affecting acetylcholine synthesis, storage and release, affecting the enzyme
PALACIOS, JM +2 more
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From the cholinergic gene locus to the cholinergic neuron
Journal of Physiology-Paris, 1998The cholinergic gene locus (CGL) was first identified in 1994 as the site (human chromosome 10q11.2) at which choline acetyltransferase and a functional vesicular acetylcholine transporter are co-localized. Here, we present recent neuroanatomical, developmental, and evolutionary insights into the chemical coding of cholinergic neurotransmission that ...
E, Weihe +7 more
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Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
Nature Reviews Neuroscience, 2023M. Ananth +4 more
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Experientia, 1977
Soluble proteins obtained from presynaptic cholinergic vesicles have been tested regarding their effects to modify postsynaptic spike generation. The results suggest that these proteins (or derivatives, incl. glycopeptides) may act as modulators in increasing the effectiveness and duration of postsynaptic spike generation.
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Soluble proteins obtained from presynaptic cholinergic vesicles have been tested regarding their effects to modify postsynaptic spike generation. The results suggest that these proteins (or derivatives, incl. glycopeptides) may act as modulators in increasing the effectiveness and duration of postsynaptic spike generation.
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Pharmacology & Therapeutics. Part B: General and Systematic Pharmacology, 1976
NUMEROUS accounts have been given on the influence on spinal reflex activity of acetylcholine and cholinesterase inhibitors under different experimental conditions and in various animal species (cf. Machne and Unna. 1963). However, when scrutinizing the early literature, it is hard to obtain satisfying informations concerning a state of rigidity ...
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NUMEROUS accounts have been given on the influence on spinal reflex activity of acetylcholine and cholinesterase inhibitors under different experimental conditions and in various animal species (cf. Machne and Unna. 1963). However, when scrutinizing the early literature, it is hard to obtain satisfying informations concerning a state of rigidity ...
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Acetylcholine (ACh) is a leading regulatory neurotransmitter in the nervous system, which functions both directly and as modulator of other neurotransmitters. It is found in the central and peripheral nervous system, as well as in the autonomic system-both sympathetic and parasympathetic. In the central nervous system (CNS), ACh functions not only as a
Hermona, Soreq, Adi, Bar, Iddo, Paldor
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Hermona, Soreq, Adi, Bar, Iddo, Paldor
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Cholinergic Systems and Multiple Cholinergic Receptors in Ocular Tissues
Journal of Ocular Pharmacology and Therapeutics, 1985Acetylcholine (ACh), choline acetyltransferases and cholinesterases occur in cornea, iris-ciliary body complex and retina of several vertebrates. In cornea, ACh may serve as a sensory transmitter as well as a local hormone, the function of which is not delineated.
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2021
Abstract Acetylcholine (ACh) is a major neurotransmitter in the central and peripheral nervous systems. Cholinergic neurons in the central nervous system include the basal forebrain cholinergic group that projects to the cerebral cortex and has a major role in attention, sensory processing, and memory; the mesopontine group that projects
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Abstract Acetylcholine (ACh) is a major neurotransmitter in the central and peripheral nervous systems. Cholinergic neurons in the central nervous system include the basal forebrain cholinergic group that projects to the cerebral cortex and has a major role in attention, sensory processing, and memory; the mesopontine group that projects
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Distribution of AChE in cholinergic and non-cholinergic neurons
Brain Research, 1981Intracellular and surface acetylcholinesterase activities were determined for individual cholinergic and non-cholinergic neurons dissected from the central nervous system of the leech. Echothiophate pretreatment was used to inhibit selectively extracellular enzyme.
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The cholinergic hypothesis of geriatric memory dysfunction.
Science, 1982R. Bartus, R. Dean, B. Beer, A. Lippa
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