Results 11 to 20 of about 28,548 (243)

Differential pharmacological and sex-specific effects of antimuscarinic agents at the hypoglossal motor nucleus in vivo in rats

Scientific Reports, 2022
Successful cholinergic-noradrenergic pharmacotherapy for obstructive sleep apnea (OSA) is thought to be due to effects at the hypoglossal motor nucleus (HMN). Clinical efficacy varies with muscarinic-receptor (MR) subtype affinities. We hypothesized that
Sepehr Niakani, Hattie Liu, Wen-Ying Liu, Richard L. Horner   +3 more
doaj   +1 more source

Social Isolation: How Can the Effects on the Cholinergic System Be Isolated?

Frontiers in Pharmacology, 2021
Social species form organizations that support individuals because the consequent social behaviors help these organisms survive. The isolation of these individuals may be a stressor. We reviewed the potential mechanisms of the effects of social isolation
Jaromir Myslivecek
doaj   +1 more source

Cholinergic Mechanisms in Spinal Locomotion - Potential Target for Rehabilitation Approaches

Frontiers in Neural Circuits, 2014
Previous experiments implicate cholinergic brainstem and spinal systems in the control of locomotion. Our results demonstrate that the endogenous cholinergic propriospinal system, acting via M2 and M3 muscarinic receptors, is capable of consistently ...
L M Jordan, J R McVagh, B R Noga, A M Cabaj, A M Cabaj, H eMajczyński, Urszula eSlawinska, J eProvencher, H eLeblond, S eRossignol   +9 more
doaj   +1 more source

Rapid Desensitization with Autologous Sweat in Cholinergic Urticaria

Allergology International, 2011
Background: The majority of patients with cholinergic urticaria presents with strong hypersensitivity to autologous sweat. Patients with severe cholinergic urticaria are frequently resistant to H1 antagonists which are used in conventional therapies for ...
Takeshi Kozaru, Atsushi Fukunaga, Kumiko Taguchi, Kanako Ogura, Tohru Nagano, Masahiro Oka, Tatsuya Horikawa, Chikako Nishigori   +7 more
doaj   +1 more source

Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia.

PLoS ONE, 2019
In early-onset generalized torsion dystonia, caused by a GAG deletion in TOR1A (DYT1), enhanced striatal cholinergic activity has been suggested to be critically involved. Previous studies have shown increased acetylcholine levels in the striatum of DYT1
Franziska Richter, Laura Klein, Christin Helmschrodt, Angelika Richter   +3 more
doaj   +1 more source

Unilateral mydriasis secondary to ipratropium bromide in a critically ill patient

Journal of Emergencies, Trauma and Shock, 2012
Unilateral dilated pupil in a critical patient under sedation is an important clinical sign that requires prompt evaluation. An exhaustive assessment must be performed, including neurological examination and imaging tests, and pharmacological causes must
Luciano Santana-Cabrera, Ernesto José Fernández-Tagarro, Beatriz del Amo-Nolasco, Nieves Jaén-Sánchez, Juan José Cáceres-Agra   +4 more
doaj   +1 more source

Treatment of uncommon sites of focal primary hyperhidrosis: experience with pharmacological therapy using oxybutynin

Clinics, 2014
OBJECTIVES: Primary hyperhidrosis usually affects the hands, armpits, feet and cranio-facial region. Sweating in other areas is common in secondary hyperhidrosis (after surgery or in specific clinical conditions). Oxybutynin has provided good results and
Marcelo Passos Teivelis, Nelson Wolosker, Mariana Krutman, Paulo Kauffman, José Ribas Milanez de Campos, Pedro Puech-Leão   +5 more
doaj   +1 more source

A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. [PDF]

PLoS ONE, 2012
BACKGROUND: Cocaine increases the level of endogenous dopamine (DA) in the striatum by blocking the DA transporter. Endogenous DA modulates glutamatergic inputs to striatal neurons and this modulation influences motor activity.
Alessandro Tozzi, Antonio de Iure, Valentina Marsili, Rosaria Romano, Michela Tantucci, Massimiliano Di Filippo, Cinzia Costa, Francesco Napolitano, Nicola Biagio Mercuri, Franco Borsini, Carmen Giampà, Francesca Romana Fusco, Barbara Picconi, Alessandro Usiello, Paolo Calabresi   +14 more
doaj   +1 more source

Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia

New England Journal of Medicine, 2021
The muscarinic receptor agonist xanomeline has antipsychotic properties and is devoid of dopamine receptor-blocking activity but causes cholinergic adverse events. Trospium is a peripherally restricted muscarinic receptor antagonist that reduces peripheral cholinergic effects of xanomeline. The efficacy and safety of combined xanomeline and trospium in
Brannan, Stephen K., Sawchak, Sharon, Miller, Andrew C., Lieberman, Jeffrey A., Paul, Steven M., Breier, Alan   +5 more
openaire   +2 more sources

Evaluation of Different Combined Regimens in the Treatment of Cholinergic Urticaria

World Allergy Organization Journal, 2012
Background Cholinergic urticaria is uncommon and accounts for 10% of all young adults. To date, there is no effective therapy for cholinergic urticaria.Objective To determine the therapeutic efficacy of different drug combinations in the treatment of ...
Abdulghani M. Alsamarai, MD, PhD, Ali A. Hasan, MBChB, HDIA, Amina H. Alobaidi, BSc, MSc, PhD, DHPE   +2 more
doaj   +1 more source