Results 291 to 300 of about 31,317 (345)

Cholinergic antagonists in a solitary wasp venom

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1986
The venom of the solitary wasp Philanthus triangulum contains a cholinergic antagonist of the nicotinic receptor of the rectus abdominis muscle of the frog, Xenopus laevis. The venom of African P. triangulum contains two different cholinergic factors, a competitive and a non-competitive antagonist. The venom of the European P.
T, Piek, P, Mantel
openaire   +2 more sources

Cholinergic antagonists and REM sleep generation

Brain Research, 1991
In this study we extended our observations on the role of M1 and M2 muscarinic receptors in mediating the cholinergic induction of REM sleep. Cats were chronically implanted with sleep recording electrodes and microinjections of Ringer's or muscarinic antagonists followed by the relatively specific M2 muscarinic agonist, cis-methyl-dioxolane (cisdioxo),
J, Velazquez-Moctezuma, M, Shalauta, J C, Gillin, P J, Shiromani   +3 more
openaire   +2 more sources

[Effects of cholinergic antagonists in stress].

Patologicheskaia fiziologiia i eksperimental'naia terapiia, 2007
Effects of methacine, hexamethonium and their combinations with neostigmine on activity of B-lymphocytes in various phases of immune response and development of stress ulcers induced in animals were studied. The drugs were found to modulate B-lymphocyte activity for 28 days and longer.
G I, Nezhinskaia, N A, Losev, N S, Sapronov   +2 more
openaire   +2 more sources

Morphine Withdrawal Syndrome Responses to Cholinergic Antagonists and to a Partial Cholinergic Agonist

Nature, 1973
MORPHINE impairs the release of acetylcholine (ACh) at muscarinic and nicotinic sites in the periphery1–3, and within the brain4–8. Paton9 suggested that morphine's ability to impair ACh release might be the origin of the morphine withdrawal reaction. He proposed that ACh could accumulate within cholinergic terminals during habituation to the narcotic ...
C, Pinsky, R C, Frederickson, A J, Vazquez   +2 more
openaire   +2 more sources

The effect of cholinergic antagonists on a central response to nicotine

Experientia, 1982
Mecamylamine and hexamethonium antagonize the prostration response of rats to centrally-administered nicotine; decamethonium and d-tubocurarine are less effective. physostigmine does not elicit the response. Nicotine's central cholinergic effect thus may contribute to but does not fully account for its action.
L S, Schwab, M F, Kritzer
openaire   +2 more sources

Aryldiazonium Salts as Antagonists at Cholinergic Muscarinic Receptors

Canadian Journal of Physiology and Pharmacology, 1974
A series of aryldiazonium salts were synthesized and tested for inhibitory activity on the longitudinal muscle of the guinea pig ileum. The most potent member of the series, benzenediazonium fluoborate (BDF) (at 10−4 M with incubation for 5 min), produced a dose ratio of 600 for acetylcholine (Ach), 58 for cis-2-methyl-4-trimethylammonium methyl-1,3 ...
D H, Ross, D J, Triggle
openaire   +2 more sources

Methylatropine blocks the central effects of cholinergic antagonists

Behavioural Pharmacology, 1994
These studies were conducted in order to establish the dose dependency and relative peripheral versus central activity of four prototypical cholinergic antagonists on the rodent passive avoidance response, a widely used animal model of retention.
R.D., Smith, M.E., Grzelak, V.L., Coffin
openaire   +2 more sources

Parasympathetic non-adrenergic, non-cholinergic transmission in rat parotid glands: Effects of cholecystokinin-A and -B receptor antagonists on the secretory response

Regulatory Peptides, 2008
Recent studies show i.v. administered pentagastrin and cholecystokinin to evoke protein/amylase secretion from the rat parotid gland and to stimulate gland protein synthesis, the two phenomena being abolished by cholecystokinin receptor antagonists.
J Ekstrom
exaly   +2 more sources

Amitriptyline and nortriptyline as antagonists of central and peripheral cholinergic activation

Psychopharmacologia, 1963
1. The anticholinergic activity of amitriptyline and a new antidepressant, nortriptyline, which is a secondary amine related to amitriptyline, were compared on guinea pig ileum and salivation of dogs. Both are active anticholinergic agents, but somewhat atypical, by these tests.
R C, RATHBUN, I H, SLATER
openaire   +2 more sources

Effects of cholinergic agonists and antagonists on morphine-withdrawal syndrome

Psychopharmacology, 1976
The effects of pilocarpine, atropine and dexetimide were studied on the occurrence and intensity of morphine-withdrawal signs observed after cessation of chronic morphine injections. Pilocarpine was effective in reducing both 'wet-dog' like body shakes and aggression but it increased diarrhea and weight loss.
M D, Hynes, G, Gianutsos, H, Lal
openaire   +2 more sources