Results 301 to 310 of about 31,317 (345)

AGONIST‐ANTAGONIST INTERACTION AT THE CHOLINERGIC RECEPTOR OF DENERVATED DIAPHRAGM

Australian Journal of Experimental Biology and Medical Science, 1972
SummaryA study has been made of the cholinergic receptor induced by chronic denervation in the rat diaphragm. The agonists acetylcholine, carbachol and tetramethylammonium produced a dose‐dependent contraction of the denervated diaphragm. These agonists also brought about a graded depolarization of the muscle cells.
S E, Freeman, R J, Turner
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Cholinergic agonists and antagonists

1983
This chapter reviews the effects of the parasympathetic nervous system on the physiological properties of the cardiovascular system and the mechanisms by which these effects are produced. In the context of this background, the cardiovascular effects of agents that augment and antagonize parasympathetic nervous system activity will be discussed.
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Naloxone modulates the behavioral effects of cholinergic agonists and antagonists

Psychopharmacology, 1991
Peripheral glucose administration enhances memory in rodents and humans. Recent findings suggest that glucose may affect behavior, in part, by augmenting central cholinergic functions and by attenuating central opiate functions. The present experiments examined interactions between an opiate antagonist, naloxone, and cholinergic agents to determine ...
D L, Walker, T, McGlynn, C, Grey, M, Ragozzino, P E, Gold   +4 more
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Bovine pancreatic polypeptide as an antagonist of muscarinic cholinergic receptors

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1987
In dispersed acini from rat pancreas, it was found that bovine pancreatic polypeptide (BPP) and its C-fragment hexapeptide amide (PP-6), at concentrations of 0.1 and 30 microM, respectively, could significantly inhibit amylase secretion stimulated by carbachol (P less than 0.01 or 0.05, respectively), and this inhibition by BPP was dose dependent ...
G Z, Pan, L, Lu, J M, Qian, B G, Xue
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Antagonists of cholinergic and serotonergic responses of Aplysia buccal muscle

Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1994
Cholinergic and serotonergic receptors of Aplysia californica buccal muscles were characterized pharmacologically by determining compounds that effectively inhibited contractile responses to acetylcholine (ACh) and modulatory effects of serotonin (5-HT), respectively. pA50 for ACh to elicit contraction averaged 4.7 +/- 0.1 (mean +/- SE, equivalent to 2
J L, Ram, K, Judge, M A, Jednak
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Deoxycholic Acid Conjugates Are Muscarinic Cholinergic Receptor Antagonists

Pharmacology, 2002
In the course of examining the actions of major human bile acids on cholinergic receptors, we discovered that conjugates of lithocholic acid are partial muscarinic agonists. In the present communication, we report that conjugates of deoxycholic acid (DC) act as cholinergic muscarinic receptor antagonists.
Jean-Pierre, Raufman, Ying, Chen, Piotr, Zimniak, Kunrong, Cheng   +3 more
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INTERACTIONS OF FLUORESCENT CHOLINERGIC ANTAGONISTS WITH THE MEMBRANE-BOUND ACETYLCHOLINE RECEPTOR

Neurochemistry International, 1980
The synthesis of pyrenyl-choline derivatives is reported. The interactions of these compounds with the acetylcholine receptor has been studied in developing chick myotubes in culture and in the adult frog neuromuscular junction with electrophysiological techniques.
Y P, Tan, W, Stender, A L, Harvey, B, Soria, F J, Barrantes   +4 more
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Discriminative Stimulus Effects of Cholinergic Agonists and the Actions of Their Antagonists

1988
Both muscarinic- and nicotinic-cholinergic agonists have been used for discrimination training, but only nicotine has been studied extensively. The limited information available suggests that the discriminative stimulus effects of drugs classified as muscarinic-cholinergic agonists are blocked competitively by atropine but not by ganglion-blockers. The
I P, Stolerman, R, Kumar, C, Reavill
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Nicotinic cholinergic antagonists: A novel approach for the treatment of autism

Medical Hypotheses, 2006
Evidence supports the hypothesis that normalization of cholinergic tone by selective antagonism of neuronal nicotinic acetylcholine receptors (NNRs) may ameliorate the core symptoms of autism. As often is the case, epidemiology has provided the first important clues.
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Substance P antagonists and the role of tachykinins in non-cholinergic bronchoconstriction

Life Sciences, 1984
Electrical field stimulation of guinea-pig isolated hilus bronchi induced tetrodotoxin-sensitive contractions of which only a minor part could be inhibited by atropine. The remaining non-cholinergic bronchoconstriction was antagonized by a heptapeptide and an undecapeptide substance P (SP) analogue (Arg5, D-Trp7,9) SP5-11, IC50 = 24.0 microM and (D ...
J A, Karlsson, M J, Finney, C G, Persson, C, Post   +3 more
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