Results 31 to 40 of about 28,548 (243)

Changes in attention variables in those who treated with anticholinergic agents for nonmonosymptomatic enuresis [PDF]

Investigative and Clinical Urology, 2020
Purpose: Brain dysfunction related to areas regarding attention and arousal may occur not only in patients with attention-deficit/hyperactivity disorder (ADHD) but also in patients with enuresis and daytime symptoms.
Gwan Jang , Young Jae Im , Jungyo Suh , Kwanjin Park   +3 more
doaj   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Nicotinic Receptor Activity Alters Synaptic Plasticity

The Scientific World Journal, 2001
Studies using specific agonists, antagonists, and lesions have shown that nicotinic cholinergic systems participate in attention, learning, and memory[1,2].
John A. Dani
doaj   +1 more source

Cholinergic agonist-antagonist interactions on neocortical and limbic EEG activation [PDF]

International Journal of Neuropharmacology, 1967
Abstract EEG activation and behavioral arousal following acetylcholine (0.007 mg/kg) intravenously was blocked by pretreatmeat with the muscarinic (m) cholinergic antagonists methyl atropine and atropine (0·3 mg/kg). On the other hand this was not affected by the nicotinic (n) ganglionic cholinergic antagonists trimethidinium (1 mg/kg) and ...
Kjen-Ichi Yamamoto,, Domino, Edward F.
openaire   +3 more sources

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, EarlyView.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Anticholinergic Drug Use on Admission and the Risk of In-Hospital Falls in Older Hospitalized Patients

Clinical Interventions in Aging, 2022
Özge Akgün,1 Christian Oudshoorn,1 Francesco US Mattace-Raso,1 Angelique Egberts1,2 1Department of Internal Medicine, Section of Geriatric Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands; 2Department of Hospital Pharmacy ...
Akgün Ö, Oudshoorn C, Mattace-Raso FUS, Egberts A   +3 more
doaj  

Potentially inappropriate anticholinergic drug prescriptions for patients with Sjögren's syndrome

Journal of Translational Autoimmunity, 2019
Sjögren's syndrome is characterized by the involvement of exocrine glands, manifesting with xerostomia and xerophthalmia. The objective was to determine the treatment received and identify potentially inappropriate prescriptions by estimating the ...
Luis Fernando Valladales-Restrepo, Jorge Enrique Machado-Alba   +1 more
doaj   +1 more source

The mammalian efferent vestibular system utilizes cholinergic mechanisms to excite primary vestibular afferents

Scientific Reports, 2021
Electrical stimulation of the mammalian efferent vestibular system (EVS) predominantly excites primary vestibular afferents along two distinct time scales.
Glenn T. Schneider, Choongheon Lee, Anjali K. Sinha, Paivi M. Jordan, Joseph C. Holt   +4 more
doaj   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source