Results 51 to 60 of about 28,548 (243)

Sudden death in strabismus surgery under local anaesthesia: a case report [PDF]

Journal of Emergency Practice and Trauma, 2017
Oculocardiac reflex (OCR) sometimes occurs as a result of pressure on the eye or traction of the intraorbital surrounding structures during ophthalmic surgery. This can result in bradycardiac arrhythmia and cardiac arrest.
Mahesh Chand Meena, Kuldeep Panchal, Mukta Rani   +2 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Pinnatoxins’ Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health

Marine Drugs, 2019
Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine ...
Nicolas Delcourt, Emmeline Lagrange, Eric Abadie, Valérie Fessard, Jean-Marc Frémy, Jean-Paul Vernoux, Marie-Bénédicte Peyrat, Thomas Maignien, Nathalie Arnich, Jordi Molgó, César Mattei   +10 more
doaj   +1 more source

Long-term results of oxybutynin use in treating facial hyperhidrosis [PDF]

Anais Brasileiros de Dermatologia, 2014
BACKGROUND: Facial hyperhidrosis can lead to serious emotional distress. Video-assisted thoracic sympathectomy resolves symptoms effectively, though it may be associated with compensatory hyperhidrosis, which may be more common in patients undergoing ...
Nelson Wolosker, Marcelo Passos Teivelis, Mariana Krutman, Taiz Pereira Dozono de Almeida Campbell, Paulo Kauffman, José Ribas de Campos, Pedro Puech-Leão   +6 more
doaj   +1 more source

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

Physiological functions of the cholinergic system in immune cells

Journal of Pharmacological Sciences, 2017
T and B cells, macrophages and dendritic cells (DCs) all express most of the components necessary for a functional cholinergic system. This includes choline acetyltransferase (ChAT), muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and ...
Takeshi Fujii, Masato Mashimo, Yasuhiro Moriwaki, Hidemi Misawa, Shiro Ono, Kazuhide Horiguchi, Koichiro Kawashima   +6 more
doaj   +1 more source

Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review

Food Safety and Health, EarlyView.
Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra, Monika Bhadauria, Satendra Kumar Nirala   +2 more
wiley   +1 more source

Avoiding anticholinergic burden in neuropsychiatric treatments comorbid with alcohol use disorder [PDF]

Dementia & Neuropsychologia
Alcohol use disorder (AUD) frequently co-occurs with neuropsychiatric conditions such as insomnia, anxiety, depression, and psychosis. The management of these comorbidities requires careful pharmacological consideration, particularly the avoidance of ...
Ismael Segura-Ulate
doaj   +1 more source

Preclinical advances in antibodies against N‐terminal Aβ4‐x species for Alzheimer's disease and cerebral amyloid angiopathy

Ibrain, EarlyView.
This review provides an update on monoclonal and polyclonal antibodies developed to specifically target amyloid beta (Aβ) truncated species starting at residue phenylalanine 4 (Aβ4‐x) in Alzheimer's disease and cerebral amyloid angiopathy preclinical studies (in vitro and in vivo models).
Maria Luisa Valle, Donatello Arienzo
wiley   +1 more source

Responses of pigeon vestibular hair cells to cholinergic agonists and antagonists [PDF]

Brain Research, 2011
Acetylcholine (ACh) is the major neurotransmitter released from vestibular efferent terminals onto hair cells and afferents. Previous studies indicate that the two classes of acetylcholine receptors, nicotinic (nAChRs) and muscarinic receptors (mAChRs), are expressed by vestibular hair cells (VHCs).
Gang Q, Li, Manning J, Correia
openaire   +2 more sources