Results 71 to 80 of about 31,317 (345)

Duration of Antimuscarinic Administration for Treatment of Overactive Bladder Before Which One Can Assess Efficacy: An Analysis of Predictive Factors [PDF]

International Neurourology Journal, 2015
Purpose: To determine the duration of antimuscarinic therapy for overactive bladder syndrome (OAB) appropriate for assessment of the efficacy of treatment, and to evaluate the possible predictive factors for response to therapy. Methods: All OAB patients
Sheng-Mou Hsiao, Chun-Hou Liao, Ho-Hsiung Lin, Hann-Chorng Kuo   +3 more
doaj   +1 more source

Cholinergic interneurons control the excitatory input to the striatum

, 2007
How the extent and time course of presynaptic inhibition depend on the action potentials of the neuron controlling the terminals is unknown. We investigated this issue in the striatum using paired recordings from cholinergic interneurons and projection ...
Bracci, Enrico, Pakhotin, Pavel
core   +1 more source

Paraherquamide and 2-Deoxy-paraherquamide Distinguish Cholinergic Receptor Subtypes in Ascaris Muscle [PDF]

, 2002
Paraherquamide is a novel natural anthelmintic product with a mode of action that is incompletely characterized. Nicotine and cholinergic-anthelmintic agonists of different chemical classes were used to produce contraction in Ascaris muscle strips ...
Thompson, David P., Trailović, Saša, Geary, Timothy G., Burns, Teresa A., Robertson, P. Alan, Martin, Richard J., Clark, Cheril L.   +6 more
core   +1 more source

Synergistic Enhancement: Whole Wheat Substrate Improves Memory in Mice by Optimizing Folate Metabolism and Systemic Antioxidant Capacity

Food Bioengineering, EarlyView.
ABSTRACT This study rigorously assessed the impact of folic acid‐fortified whole wheat products on mitigating mild liver injury caused by prolonged excessive folic acid consumption, improving folic acid bioavailability, and enhancing spatial cognitive functions in mice over a 48‐day intervention period.
Yan Qi, Songyi Lin, Meina Zhang, Yue Tang   +3 more
wiley   +1 more source

Avoiding anticholinergic burden in neuropsychiatric treatments comorbid with alcohol use disorder [PDF]

Dementia & Neuropsychologia
Alcohol use disorder (AUD) frequently co-occurs with neuropsychiatric conditions such as insomnia, anxiety, depression, and psychosis. The management of these comorbidities requires careful pharmacological consideration, particularly the avoidance of ...
Ismael Segura-Ulate
doaj   +1 more source

Synthesized flavone attenuates diabetes‐induced neurodegeneration through regulation of oxidative stress and metabolic‐neurodegenerative molecular pathways

Ibrain, EarlyView.
Neuroprotective efficacy of flavone (2‐phenyl‐4H‐chromen‐4‐one). The study aimed to explore the potential of a synthetic derivative (flavone) of a phytocompound, which is involved in neuroprotection activities. Experimental strategies included the characteristics of compound, in‐silico analysis, and in vivo assessments.
Karishma Sen, Anita Sakarwal, Heera Ram, Suman K. Saha, Nirmal K. Rana, Dharmveer Yadav, Sunil Dutt Shukla, Mukesh Kumar Yadav, Balachandar Vellingiri, Vikas Kumar   +9 more
wiley   +1 more source

Dopaminergic novelty detection and theta oscillations: Virtual reality‐based adaptive interventions for cognitive enhancement in aging

Ibrain, EarlyView.
Aging‐related cognitive decline is associated with reduced dopaminergic signaling and disrupted theta oscillations, which together impair novelty detection and memory formation. This review shows how VR environments can be used to deliver adaptive, novelty‐rich stimuli that engage dopaminergic circuits and entrain theta rhythms, thereby enhancing ...
Abraham Olufemi Asuku, Ayodeji Johnson Ajibare   +1 more
wiley   +1 more source

Cognition in menopausal women

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Cognitive health in postmenopausal women is significantly affected by hormonal shifts, especially the drop in estrogen levels. This review explores the intricate relationship between menopause and cognitive functions across six domains: perception, attention, memory, language, executive functioning, and motor skills.
Suvarna Khadilkar, Jharna Mahajan (Bhanushali), Anuradha P. Mahto, Satish Khadilkar   +3 more
wiley   +1 more source

Complement C3 mediates adolescent social isolation‐induced hippocampal synaptic deficits and sex‐specific emotional dysfunction

Interdisciplinary Medicine, EarlyView.
Adolescent social isolation disrupts hippocampal function and exacerbates emotional symptoms, with sex‐specific patterns, as shown by human studies. In mice, social isolation decreased hippocampal synaptic density and calcium signaling, upregulated complement proteins, and activated complement‐mediated microglial synaptic phagocytosis.
Yuwan Qi, Siying Weng, Qiao Yin, Mengqi Li, Liang Shen, Enyou Qiao, Lu Gao, Yihan Wang, Yuxuan Li, Weifeng Luo, Qilin Zhang, Jing Wang, Jianfeng Feng, Qifei Cong   +13 more
wiley   +1 more source

Interaction between the antioxidant activity of curcumin and cholinergic system on memory retention in adult male Wistar rats [PDF]

Iranian Journal of Basic Medical Sciences, 2015
Objective(s):  The cholinergic system plays an important role in learning and memory. This study investigated the effects of curcumin (turmeric extract) and the cholinergic system and their interaction on memory retention of passive avoidance learning in
Zeynab Sarlak, Shahrbanoo Oryan, Mehrnoush Moghaddasi   +2 more
doaj