Results 1 to 10 of about 1,494,790 (309)

Optogenetic stimulation of cholinergic fibers for the modulation of insulin and glycemia. [PDF]

Sci Rep, 2021
Abstract Previous studies have demonstrated stimulation of endocrine pancreas function by vagal nerve electrical stimulation. While this increases insulin secretion, expected concomitant reductions in circulating glucose do not occur. A complicating factor is the non-specific nature of electrical nerve stimulation.
Fontaine AK, Ramirez DG, Littich SF, Piscopio RA, Kravets V, Schleicher WE, Mizoguchi N, Caldwell JH, Weir RFF, Benninger RKP.   +9 more
europepmc   +7 more sources

Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep. [PDF]

Elife, 2016
Cholinergic projections from the basal forebrain and brainstem are thought to play important roles in rapid eye movement (REM) sleep and arousal. Using transgenic mice in which channelrhdopsin-2 is selectively expressed in cholinergic neurons, we show that optical stimulation of cholinergic inputs to the thalamic reticular nucleus (TRN) activates local
Ni KM, Hou XJ, Yang CH, Dong P, Li Y, Zhang Y, Jiang P, Berg DK, Duan S, Li XM.   +9 more
europepmc   +9 more sources

Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers

Neuron, 2022
Transmission from striatal cholinergic interneurons (CINs) controls dopamine release through nicotinic acetylcholine receptors (nAChRs) on dopaminergic axons. Anatomical studies suggest that cholinergic terminals signal predominantly through non-synaptic volume transmission.
Kramer PF, Brill-Weil SG, Cummins AC, Zhang R, Camacho-Hernandez GA, Newman AH, Eldridge MAG, Averbeck BB, Khaliq ZM   +8 more
semanticscholar   +6 more sources

The Influence of Resiniferatoxin (RTX) and Tetrodotoxin (TTX) on the Distribution, Relative Frequency, and Chemical Coding of Noradrenergic and Cholinergic Nerve Fibers Supplying the Porcine Urinary Bladder Wall [PDF]

Toxins, 2017
The present study investigated the influence of intravesically instilled resiniferatoxin (RTX) or tetrodotoxin (TTX) on the distribution, number, and chemical coding of noradrenergic and cholinergic nerve fibers (NF) supplying the urinary bladder in ...
Ewa Lepiarczyk, Agnieszka Bossowska, Jerzy Kaleczyc, Agnieszka Skowrońska, Marta Majewska, Michal Majewski, Mariusz Majewski   +6 more
doaj   +3 more sources

Cholinergic Fibers and Muscarinic Receptors in the Central Auditory System

The Journal of Kansai Medical University, 2012
アルツハイマー病では中枢聴覚系の機能障害を示唆する症状を合併する場合が少なくない．また細胞変性等の病変が疾病脳の聴覚上行路各部位にも確認されている．本研究ではマウス脳のこれらの部位におけるコリン線維とムスカリン性受容体（m2，m3タイプ）の発現分布密度を測定した．聴覚上行路諸核で，これらコリン線維・受容体を介する情報伝達・変換が聴覚の伝達に一定の意義を有することが，本研究から強く示唆された．
Satoko Hamada, Stefan Trifonov, Takeshi Houtani, Masahiko Kase, Yuji Yamashita, Kazuyasu Baba, Jun-ichi Shimizu, Masato Maruyama, Koichi Tomoda, Toshio Yamashita, Tetsuo Sugimoto   +10 more
semanticscholar   +4 more sources

Cholinergic fiber aberrations in nucleus basalis lesioned rat and Alzheimer's disease [PDF]

Neurobiology of Aging, 1992
Innervation density and morphological aberrations of cholinergic fibers were studied with choline acetyltransferase (ChAT) immunocytochemistry and acetylcholinesterase (AChE) histochemistry in 30-35 month-old aged rats and rats with long-term bilateral lesions of the magnocellular basal nucleus (MBN).
GAYKEMA, RPA, NYAKAS, C, HORVATH, E, HERSH, LB, MAJTENYI, C, LUITEN, PGM   +5 more
openaire   +6 more sources

Sound exposure dynamically induces dopamine synthesis in cholinergic LOC efferents for feedback to auditory nerve fibers

eLife, 2020
Lateral olivocochlear (LOC) efferent neurons modulate auditory nerve fiber (ANF) activity using a large repertoire of neurotransmitters, including dopamine (DA) and acetylcholine (ACh).
Jingjing Sherry Wu, Eunyoung Yi, Marco Manca, Hamad Javaid, Amanda M. Lauer, E. Glowatzki   +5 more
semanticscholar   +2 more sources

Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the teleost Cyprinus carpio [PDF]

European Journal of Histochemistry, 2018
Cholinergic systems play a role in basic cerebral functions and its dysfunction is associated with deficit in neurodegenerative disease. Mechanisms involved in human brain diseases, are often approached by using fish models, especially cyprinids, given ...
Arianna Casini, Rosa Vaccaro, Mattia Toni, Carla Cioni   +3 more
doaj   +4 more sources

Arthritis and cholinergic transition of sympathetic nerve fibers [PDF]

, 2016
Fragestellung. Die Dichte von sympathischen Nervenfasern, welche über die Expression von Tyrosin-hydroxylase (TH, Schlüsselenzym der Katecholaminbiosynthese) analysiert wird, ist bei Arthritis im entzündeten Gewebe erniedrigt. Allerdings ist bekannt, dass sympathische Nervenfasern unter bestimmten Bedingungen, wie sie beispielsweise während der ...
Hubert Stangl
openaire   +3 more sources

Elevated Levels of miR-144-3p Induce Cholinergic Degeneration by Impairing the Maturation of NGF in Alzheimer’s Disease

Frontiers in Cell and Developmental Biology, 2021
Cholinergic degeneration is one of the key pathological hallmarks of Alzheimer’s disease (AD), a condition that is characterized by synaptic disorders and memory impairments. Nerve growth factor (NGF) is secreted in brain regions that receive projections
Lan-Ting Zhou, Lan-Ting Zhou, Juan Zhang, Juan Zhang, Lu Tan, Lu Tan, He-Zhou Huang, He-Zhou Huang, Yang Zhou, Yang Zhou, Zhi-Qiang Liu, Zhi-Qiang Liu, Youming Lu, Ling-Qiang Zhu, Ling-Qiang Zhu, Chengye Yao, Dan Liu   +16 more
doaj   +2 more sources