Results 131 to 140 of about 1,448,122 (321)

In vivo and in silico models of Drosophila for Parkinson's disease

The FEBS Journal, EarlyView.
In vivo and in silico models of Drosophila offer valuable advantages in the generation, analysis, and interpretation of complex biological data, thereby significantly advancing our understanding of Parkinson's disease. Molecular‐level measurements and phenotypic data from Drosophila are extensively utilised in metabolic network modeling and artificial ...
Müberra Fatma Cesur, Rachel Strazdins, Souvarish Sarkar, Tunahan Çakır   +3 more
wiley   +1 more source

Alzheimer’s disease hypothesis and related therapies

Translational Neurodegeneration, 2018
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause for dementia. There are many hypotheses about AD, including abnormal deposit of amyloid β (Aβ) protein in the extracellular spaces of neurons, formation of ...
Xiaoguang Du, Xinyi Wang, Meiyu Geng
doaj   +1 more source

Enteric neuropathy and the vagus nerve: Therapeutic implications

Neurogastroenterology &Motility, EarlyView.
Abstract Enteric neuropathies are characterized by abnormalities of gut innervation, which includes the enteric nervous system, inducing severe gut dysmotility among other dysfunctions. Most of the gastrointestinal tract is innervated by the vagus nerve, the efferent branches of which have close interconnections with the enteric nervous system and ...
Bruno Bonaz
wiley   +1 more source

Neurotrophin-3-enhanced nerve regeneration selectively improves recovery of muscle fibers expressing myosin heavy chains 2b [PDF]

, 1997
The purpose of this study was to evaluate the effect of neurotrophin 3 (NT-3) enhanced nerve regeneration on the reinnervation of a target muscle. Muscle fibers can be classified according to their mechanical properties and myosin heavy chain (MHC ...
Airaksinen, Averbuch-Heller, Bar, Bertelli, Braun, Burke, Davis, DiStefano, Eriksson, Ernfors, Fex, Fields, Gillespie, Goldspink, Green, Griesbeck, Henderson, Henderson, Hughes, Isaacson, Izumo, Jansson, Karpati, Kato, Kucera, Kucera, Lefebvre, Lewin, Li, Lindsay, Lohof, Maltin, Oakley, Ozaki, Pellegrino, Peter, Pette, Romanul, Salmons, Schantz, Schiaffino, Schnell, Sterne, Tessarollo, Totosy de Zepetnek, Vejsada, Wang, Wong, Wright   +48 more
core   +2 more sources

β-Amyloid(1-42)-Induced Cholinergic Lesions in Rat Nucleus Basalis Bidirectionally Modulate Serotonergic Innervation of the Basal Forebrain and Cerebral Cortex

Neurobiology of Disease, 2001
Ample experimental evidence suggests that β-amyloid (Aβ), when injected into the rat magnocellular nucleus basalis (MBN), impels excitotoxic injury of cholinergic projection neurons.
Tibor Harkany, Sheila O'Mahony, Jan Keijser, John P. Kelly, Csaba Kónya, Zsolt A. Borostyánkői, Tamás J. Görcs, Márta Zarándi, Botond Penke, Brian E. Leonard, Paul G.M. Luiten   +10 more
doaj  

Targeted optogenetic stimulation of parasympathetic cholinergic nerve fibers reveals cholinergic-purinergic cotransmission in the bladder detrusor muscle

, 2018
Parasympathetic nerve fibers control the contraction of the bladder musculature. Only a third of the contraction induced by their general activation through EFS is inhibited by antagonists of muscarinic ACh receptors. The remaining contraction is predominantly mediated via purinergic receptors.
Mirsaidov, Nodir, Justus Liebig University Giessen   +1 more
openaire   +3 more sources

The human colon: Evidence for degenerative changes during aging and the physiological consequences

Neurogastroenterology &Motility, EarlyView.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source

Averaging Transformations of Synaptic Potentials on Networks [PDF]

, 2009
The problem of the transformation of microscopic information to the macroscopic level is an intriguing challenge in computational neuroscience, but also of general mathematical importance.
Hamid Reza Noori
core   +3 more sources

Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction

Neurogastroenterology &Motility, EarlyView.
Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley   +1 more source

Disorders of gut–brain interaction through the lens of polyvagal theory

Neurogastroenterology &Motility, Volume 37, Issue 3, March 2025.
This paper introduces a metric, vagal efficiency (VE), that tracks a brainstem “switching” mechanism regulating blood pressure's effect on vagal control of the heart and gut. Potentially offering insights into gut–brain interaction disorders. Abstract This paper introduces a metric capable of tracking a hypothetical brainstem “switching” mechanism ...
Stephen W. Porges
wiley   +1 more source