Results 1 to 10 of about 2,497,858 (389)

Acetylcholine and cholinergic receptors. [PDF]

Brain Neurosci Adv, 2019
This review provides a distillate of the advances in knowledge about the neurotransmitter functions of acetylcholine over the 50-year period between 1967 and 2017, together with incremental information about the cognate nicotinic and muscarinic ...
Brown DA.
europepmc   +6 more sources

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission [PDF]

Cell Reports, 2018
Summary: Ventral tegmental area (VTA) glutamate neurons are important components of reward circuitry, but whether they are subject to cholinergic modulation is unknown.
Yijin Yan, Can Peng, Matthew C. Arvin, Xiao-Tao Jin, Veronica J. Kim, Matthew D. Ramsey, Yong Wang, Sambashiva Banala, David L. Wokosin, J. Michael McIntosh, Luke D. Lavis, Ryan M. Drenan   +11 more
doaj   +3 more sources

Imaging Cholinergic Receptors in the Brain by Positron Emission Tomography. [PDF]

J Med Chem, 2023
Cholinergic receptors represent a promising class of diagnostic and therapeutic targets due to their significant involvement in cognitive decline associated with neurological disorders and neurodegenerative diseases as well as cardiovascular impairment ...
Zhang JJ, Fu H, Lin R, Zhou J, Haider A, Fang W, Elghazawy NH, Rong J, Chen J, Li Y, Ran C, Collier TL, Chen Z, Liang SH.   +13 more
europepmc   +2 more sources

Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

Cancer Discovery, 2018
In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic ductal adenocarcinoma (PDAC) has not been ...
Bernhard W Renz, Ryota Takahashi, Zhengyu Jiang   +2 more
exaly   +2 more sources

Cholinergic Receptors in Cognitive Disorders [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1986
Abstract:Cholinergic receptors (muscarinic subtypes M1 and M2, and putative nicotinic binding) have been examined in the hippocampus obtained at autopsy from a variety of patients with cognitive disorders (Alzheimer's, Parkinson's, and Huntington's diseases, Down's Syndrome and alcoholic dementia) and compared with neurologically normal controls and ...
E. Perry, Robert H. Perry, Carthage J. Smith, D. Purohit, James R. Bonham, D. J. Dick, J. Candy, J. Edwardson, A. Fairbairn   +8 more
semanticscholar   +3 more sources

Blockade of Central Cholinergic Receptors Impairs New Learning and Increases Proactive Interference in a Word Paired-Associate Memory Task.

Behavioral Neuroscience, 2004
Experimental data and computational models suggest that blockade of muscarinic cholinergic receptors impairs paired-associate learning and increases proactive interference (E. DeRosa & M. E. Hasselmo, 2000; M. E. Hasselmo & J. M. Bower, 1993).
Alireza Atri, Seth Sherman, Kenneth A. Norman, Brenda A. Kirchhoff, Marlene M. Nicolas, Michael D. Greicius, Steven C. Cramer, Katherine H. Karlsgodt, Michael E. Hasselmo, Chantal E. Stern   +9 more
openalex   +3 more sources

Biological functions of keratinocyte cholinergic receptors.

Journal of Investigative Dermatology Symposium Proceedings, 1997
Human epidermal keratinocytes possess cholinergic enzymes, which synthesize and degrade acetylcholine, and express both nicotinic and muscarinic classes of cholinergic receptors on their cell surfaces. These receptors bind acetylcholine and initiate cellular response.
S. Grando
semanticscholar   +3 more sources

Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome

Brain, behavior, and immunity, 2015
Madlen Loebel, Patricia Grabowski, Harald Heidecke, Sandra Bauer, Leif G. Hanitsch, Kirsten Wittke, Christian Meisel, Petra Reinke, Hans‐Dieter Volk, Øystein Fluge, Olav Mella, Carmen Scheibenbogen   +11 more
openalex   +2 more sources

Beta-adrenergic and M-cholinergic receptor interactions in the pathogenesis of bronchial obstructive pulmonary diseases [PDF]

Клиническая практика, 2020
The crosstalk between the beta-2-adrenoceptor and M- cholinoreceptor systems in the airways plays one of the main roles in the pathogenesis of bronchoobstructive diseases.
Anna V. Eremenko, Kirill A. Zykov
doaj   +1 more source

An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies

Nature Communications, 2023
The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest in designing ligands for the treatment of neurological and psychiatric disorders. To develop a novel class of α7
Marie S. Prevost, Nathalie Barilone, Gabrielle Dejean de la Bâtie, Stéphanie Pons, Gabriel Ayme, Patrick England, Marc Gielen, François Bontems, Gérard Pehau-Arnaudet, Uwe Maskos, Pierre Lafaye, Pierre-Jean Corringer   +11 more
doaj   +1 more source