Results 151 to 160 of about 198,632 (298)

The neurochemical effects of prenatal exposure of cholinergic drugs on the brain postnatal monoaminergic system development

, 2010
А. А. Байрамов, А. А. Байрамов, С. Н. Прошин, С. Н. Прошин, Natalja Gavrilov, Natalja Gavrilov, N. A. Losev, N. A. Losev, Н. С. Сапронов, Н. С. Сапронов   +9 more
openalex   +1 more source

Analyzing the ‘Bradykinesia Complex’ in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Bradykinesia is the hallmark sign of parkinsonism. We recently proposed redefining bradykinesia as a complex of motor abnormalities, each reflecting separate pathophysiological elements. Objective To analyze the ‘bradykinesia complex’ in Parkinson's disease (PD) and healthy elderly individuals.
Giulia Paparella, Martina De Riggi, Antonio Cannavacciuolo, Daniele Birreci, Davide Costa, Luca Angelini, Danilo Alunni Fegatelli, Alfonso Fasano, Alberto J. Espay, Matteo Bologna   +9 more
wiley   +1 more source

The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury

Movement Disorders, EarlyView.
The “second‐hit” hypothesis proposes that both a genetic predisposition and an environmental insult—such as peripheral nerve trauma or spinal cord injury—are required for dystonia development. This review explores how neuroinflammation and maladaptive plasticity, triggered by nerve and spinal cord injury, contribute to dystonia pathogenesis.
Lisa Harder‐Rauschenberger, Chi Wang Ip   +1 more
wiley   +1 more source

[123I]-IBVM SPECT imaging of cholinergic systems in multiple system atrophy: A specific alteration of the ponto-thalamic cholinergic pathways (Ch5–Ch6)

, 2013
Joachim Mazère, Wassilios G. Meissner, Igor Sibon, F. Lamare, François Tison, Michèle Allard, Willy Mayo   +6 more
openalex   +1 more source

Possible Correlation between Cholinergic System Alterations and Neuro/Inflammation in Multiple Sclerosis [PDF]

, 2020
Valentina Gatta, Guadalupe Mengod, Marcella Reale, Ada Maria Tata   +3 more
openalex   +1 more source

Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come. [PDF]

Mol Neurodegener, 2023
Alam JJ, Nixon RA.
europepmc   +1 more source

Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal‐Weight Rats, Prevented by Perinatal Leptin Intake

Molecular Nutrition &Food Research, EarlyView.
Early‐life exposure of rats to high‐fat‐isocaloric diet leads to metabolically obese, normal‐weight phenotype, and impaired cognition. Hippocampal transcriptomic analysis reveals disruption in pathways linked to obesity and cognitive decline, which is mitigated by perinatal leptin supplementation. PBMC share common altered genes with hippocampus, which
Carmen García‐Ruano, Andrea Costa, Andreu Palou, Paula Oliver   +3 more
wiley   +1 more source

Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come. [PDF]

Mol Neurodegener, 2023
Alam JJ, Nixon RA.
europepmc   +1 more source

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking

Neuroprotection, EarlyView.
Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai, Qing Nan, Menglu Xu, Hongbao Li   +3 more
wiley   +1 more source

Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole‐Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy

ChemistryOpen, EarlyView.
GA: Oxidative stress plays a critical role in Alzheimer's disease (AD) by promoting Aβ plaque accumulation and tau pathology, accelerating neurodegeneration. Elevated reactive oxygen species contribute to cognitive decline through extensive oxidative damage.
Abdüllatif Karakaya, Ulviye Acar Çevik, Betül Kaya, Bilge Çiftçi, Adem Necip, Mesut Işık, Şükrü Beydemir, Yusuf Özkay, Zafer Asım Kaplancıklı   +8 more
wiley   +1 more source