Results 151 to 160 of about 199,578 (301)

Selective vulnerability of the aging cholinergic system to amyloid pathology revealed by induced APP overexpression. [PDF]

J Neuroinflammation
Xie K, Ryan D, Schröder S, Freund L, Bonn S, Zhou Y, Ehninger D.   +6 more
europepmc   +1 more source

Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come. [PDF]

Mol Neurodegener, 2023
Alam JJ, Nixon RA.
europepmc   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, EarlyView.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Cholinergic system in patients with chronic kidney disease: cognitive and renal implications. [PDF]

Nephrol Dial Transplant
Xu H, Eriksdotter M, Hafez G, Mitra S, Bruchfeld A, Pešić V, Unwin R, Wagner CA, Massy ZA, Zoccali C, Pepin M, Capasso G, Liabeuf S, CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target) .   +13 more
europepmc   +1 more source

Correction: Drug development targeting degeneration of the basal forebrain cholinergic system: its time has come. [PDF]

Mol Neurodegener, 2023
Alam JJ, Nixon RA.
europepmc   +1 more source

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, EarlyView.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Cognitive Impairment in Temporal Lobe Epilepsy: Alterations in the Basal Forebrain Cholinergic System. [PDF]

Brain Behav
Shen B, Jiang L, Shi Y, Guo J, Chen B, Qiu Z, Wang S, Yuan Z, Fang J.   +8 more
europepmc   +1 more source

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, EarlyView.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

The cholinergic system exerts opposing effects on memory at different stages of disease progression in Alzheimer's and Down syndrome model systems. [PDF]

Alzheimers Dement
Lisgaras CP, Scharfman HE.
europepmc   +1 more source