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The Cholinergic System in Aging
Gerontology, 1987A morphometric analysis of neuronal loss during normal aging was performed in the nucleus basalis Meynert complex of the basal forebrain (Nbm) (nucleus septi medialis, nucleus of Broca's diagonal band, nucleus basalis) and the ciliary ganglion, a peripheral cholinergic structure, in patients free of neurological and psychiatric illness.
V, Bigl +5 more
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Cholinergic system of the heart
Česká a slovenská farmacie, 2015The cholinergic system of the heart can be either of neuronal or non-neuronal origin. The neuronal cholinergic system in the heart is represented by preganglionic parasympathetic pathways, intracardiac parasympathetic ganglia and postganglionic parasympathetic neurons projecting to the atria, SA node and AV node.
Matej, Kučera, Anna, Hrabovská
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Human placental cholinergic system
Biochemical Pharmacology, 1997The occurrence of acetylcholine (ACh)-like activity in human placenta, a tissue without innervation, has been known for more than 60 years. However, the non-neuronal functions of ACh in human placenta are not clearly understood. The components of the cholinergic system-ACh, choline acetyltransferase, acetylcholinesterase, butyrylcholinesterase ...
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Cholinergic system and cell proliferation
Chemico-Biological Interactions, 2016The cholinergic system, comprising acetylcholine, the proteins responsible for acetylcholine synthesis and release, acetylcholine receptors and cholinesterases, is expressed by most human cell types. Acetylcholine is a neurotransmitter, but also a local signalling molecule which regulates basic cell functions, and cholinergic responses are involved in ...
F J, Campoy +5 more
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Extraneuronal cholinergic system in lymphocytes
Pharmacology & Therapeutics, 2000Acetylcholine (ACh) is well known as a neurotransmitter in both the central and peripheral nervous systems in mammalian species. Both muscarinic and nicotinic ACh receptors have been identified in lymphocytes isolated from thymus, lymph node, spleen, and peripheral blood, and their stimulation by muscarinic and nicotinic agonists elicits a variety of ...
K, Kawashima, T, Fujii
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2012
Acetylcholine acts via nicotinic or muscarinic receptors. There are several subtypes of nicotinic receptors that are built of pentamers of at least 17 (α1–α10, β1–β4, γ, δ, e) subunits (Wu and Lukas 2011). Several subunits of the same type may be present in any given receptor type (e.g., α1 and α5).
Andrzej T. Slominski +5 more
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Acetylcholine acts via nicotinic or muscarinic receptors. There are several subtypes of nicotinic receptors that are built of pentamers of at least 17 (α1–α10, β1–β4, γ, δ, e) subunits (Wu and Lukas 2011). Several subunits of the same type may be present in any given receptor type (e.g., α1 and α5).
Andrzej T. Slominski +5 more
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The cholinergic system and cancer
Seminars in Cancer Biology, 2008The finding that the cholinergic system may be present in non-neuromuscular cells and tissues was, at the beginning, not easily accepted by the scientific community (since 1970-1982). Today the entire set of cholinergic molecules and their functions in cell-to-cell communication, mediated by intracellular ion dynamics, is well-established.
Laura, Paleari +3 more
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Cholinergic Systems and Multiple Cholinergic Receptors in Ocular Tissues
Journal of Ocular Pharmacology and Therapeutics, 1985Acetylcholine (ACh), choline acetyltransferases and cholinesterases occur in cornea, iris-ciliary body complex and retina of several vertebrates. In cornea, ACh may serve as a sensory transmitter as well as a local hormone, the function of which is not delineated.
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Cannabinoids And The Cholinergic System
The Journal of Clinical Pharmacology, 1981Abstract: Δ9‐Tetrahydrocannabinol (THC) decreases EEG activation and causes slow waves in the cat. The EEG slow‐wave activity is accompanied by a concomitant decrease in acetylcholine release from the neocortex. The findings suggest that THC depresses the brain stem activating system. Large doses of Δ8‐ and Δ‐THC increase brain acetylcholine levels in
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The cholinergic system and spatial learning
Behavioural Brain Research, 2011Acetlylcholine (ACh) in the central nervous system is critical for a multitude of functions. Here, we concentrate on declarative memory in humans, and its equivalent episodic-like memory in rodents and highlight current understanding of cholinergic system in these processes.
Serena, Deiana +2 more
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