Dopamine D_2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive 4 nicotinic receptors via a cholinergic-dependent mechanism [PDF]
, 2010 Recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nAChRs) containing α4 and β2 subunits (α4β2*) functionally interact with G-protein-coupled dopamine (DA) D_2 receptors in basal ganglia.
Andrew R. Tapper +18 more
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Potential revival of cholinesterase inhibitors as drugs in veterinary medicine
Frontiers in Veterinary Science, 2023 The cholinergic system is involved in the regulation of all organ systems and has acetylcholine (ACh) as almost its only neurotransmitter. Any substance is called cholinergic if it can alter the action of acetylcholine. Cholinesterases (ChEs) are enzymes
Neža Žnidaršič +3 more
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Enteric dysfunctions in experimental Parkinson's disease: alterations of excitatory cholinergic neurotransmission regulating colonic motility in rats [PDF]
, 2016 Parkinson's disease (PD) is frequently associated with gastrointestinal symptoms, mostly represented by constipation and defecatory dysfunctions.
Al Harraq, Zainab +14 more
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Neurobiology of Disease, 2011 Vascular cognitive impairment has been related to dysfunction of the central cholinergic system. Studies exploring the putative relationship between vascular cognitive impairment and cholinergic dysfunction have largely been aimed at symptomatic ...
Erik I. Hoff +6 more
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66108 Central Cholinergic Synapse Formation in Optimized Primary Septal “Hippocampal Co” cultures
Journal of Clinical and Translational Science, 2021 IMPACT: Optimization of primary septal-hippocampal co-cultures facilitates studying central cholinergic synapse formation and dysfunction OBJECTIVES/GOALS: Septal cholinergic innervation to the hippocampus is critical for normal learning and memory and ...
Sarra Djemil +4 more
doaj +1 more source
Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in C. elegans [PDF]
, 2019 Mutations in pre-synaptic voltage gated calcium channels can lead to familial hemiplegic migraine type 1 (FHM1). While mammalian studies indicate that the migraine brain is hyperexcitable due to enhanced excitation or reduced inhibition, the molecular ...
Alkema, Mark J. +9 more
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The cholinergic system and Parkinson disease [PDF]
Behavioural Brain Research, 2011 Although Parkinson disease (PD) is viewed traditionally as a motor syndrome secondary to nigrostriatal dopaminergic denervation, recent studies emphasize non-motor features. Non-motor comorbidities, such as cognitive impairment, are likely the result of an intricate interplay of multi-system degenerations and neurotransmitter deficiencies extending ...
Nicolaas I, Bohnen, Roger L, Albin
openaire +2 more sources
Acetylcholine modulates the temporal dynamics of human theta oscillations during memory
Nature Communications, 2023 The cholinergic system is essential for memory. While degradation of cholinergic pathways characterizes memory-related disorders such as Alzheimer’s disease, the neurophysiological mechanisms linking the cholinergic system to human memory remain unknown.
Tamara Gedankien +6 more
doaj +1 more source
Complete morphologies of basal forebrain cholinergic neurons in the mouse
eLife, 2014 The basal forebrain cholinergic system modulates neuronal excitability and vascular tone throughout the cerebral cortex and hippocampus. This system is severely affected in Alzheimer's disease (AD), and drug treatment to enhance cholinergic signaling is ...
Hao Wu, John Williams, Jeremy Nathans
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European Journal of Histochemistry, 2021 Several cholinergic regions have been detected in the brainstem of mammals. In general, these regions are constant among different species, and the nuclear complement is maintained in animals belonging to the same order.
Pilar Marcos, Rafael Coveñas
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