Results 61 to 70 of about 199,578 (301)
Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]
, 2019 Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
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Advanced Science, EarlyView.This study presents a miniaturized bidirectional thermal stimulation system integrated with an electrode array enabling real‐time, bidirectional modulation and simultaneous recording of neural activity through localized heating and cooling. By monolithic integration of the Peltier element and with a silicon neural probe, the innovative system allows ...
Zoia Naumkina +6 more
wiley +1 more source
Making Sweat Measurable: Induction, Sampling, and Refreshment in Wearable Biofluid Sensing
Advanced Science, EarlyView.Wearable sweat sensing relies not only on chemical detection but also on controlled biofluid management. This Review integrates sweat physiology, induction strategies, and microfluidic sampling architectures, demonstrating how flux, transport, and refreshment shape measurement reliability.
Soyoung Shin, Wei Gao
wiley +1 more source
Annals of Neurology, EarlyView.Objective Parkinson's disease (PD) is increasingly conceptualized as a disorder of large‐scale brain networks, yet whether and how frequency‐specific functional connectivity reorganizes across stages remains poorly understood. In this study, we used high‐density electroencephalography (EEG) to characterize cortico‐cortical functional connectivity ...
Matteo Conti +15 more
wiley +1 more source
Corelease of acetylcholine and GABA from cholinergic forebrain neurons
eLife, 2015 Neurotransmitter corelease is emerging as a common theme of central neuromodulatory systems. Though corelease of glutamate or GABA with acetylcholine has been reported within the cholinergic system, the full extent is unknown.
Arpiar Saunders +2 more
doaj +1 more source
Translational Psychiatry, 2021 Nerve growth factor (NGF) gene therapy has been used in clinical trials of Alzheimer’s disease. Understanding the underlying mechanisms of how NGF influences memory may help develop new strategies for treatment.
Wei Zheng Eu +7 more
doaj +1 more source
Exercise enhances motor skill learning by neurotransmitter switching in the adult midbrain. [PDF]
, 2020 Physical exercise promotes motor skill learning in normal individuals and those with neurological disorders but its mechanism of action is unclear. We find that one week of voluntary wheel running enhances the acquisition of motor skills in normal adult ...
Li, Hui-Quan, Spitzer, Nicholas C
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Parkinson's disease dementia: a neural networks perspective. [PDF]
, 2015 In the long-term, with progression of the illness, Parkinson's disease dementia affects up to 90% of patients with Parkinson's disease. With increasing life expectancy in western countries, Parkinson's disease dementia is set to become even more ...
Foltynie, T, Gratwicke, J, Jahanshahi, M
core +1 more source
The central cholinergic system as a therapeutic target in Parkinson's disease
Journal of Parkinson’s DiseaseThe central cholinergic system plays a crucial role in neural communication and physiological regulation, mediated by acetylcholine (ACh) and cholinergic receptors in the central nervous system (CNS). In this review, we explore the extensive distribution
Sean J Miller +4 more
doaj +1 more source
A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies [PDF]
, 2020 Here we design and optimize a genetically encoded fluorescent indicator, iAChSnFR, for the ubiquitous neurotransmitter acetylcholine, based on a bacterial periplasmic binding protein.
Borden, Philip M. +4 more
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