Results 101 to 110 of about 46,746 (260)

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model

open access: yesEpilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher   +1 more
wiley   +1 more source

Is Australia ready for the rollout of amyloid‐targeting therapies for Alzheimer's disease? Results from a national survey characterising current infrastructure capability, workforce and training needs of memory and cognition clinics

open access: yesInternal Medicine Journal, EarlyView.
Abstract Background New amyloid‐targeting monoclonal antibody (mAb) therapies for Alzheimer's disease (AD) are currently under review by the Therapeutic Goods Administration for use in Australia. Aims To determine the infrastructure, workforce and training needs of Australian memory and cognition clinics in order to characterise health system ...
Johannes C. Michaelian   +5 more
wiley   +1 more source

A Predictive Model of Pressure Injury in Children Undergoing Living Donor Liver Transplantation Based on Machine Learning Algorithm

open access: yesJournal of Advanced Nursing, Volume 81, Issue 6, Page 3003-3012, June 2025.
ABSTRACT Aims The aim of our study was to formulate and validate a prediction model using machine learning algorithms to forecast the risk of pressure injuries (PIs) in children undergoing living donor liver transplantation (LDLT). Design A retrospective cohort study.
Xiaomei Chen   +6 more
wiley   +1 more source

Design and methodology of the harmonized diagnostic assessment of dementia for the longitudinal aging study in India: Wave 2

open access: yesJournal of the American Geriatrics Society, Volume 73, Issue 3, Page 685-696, March 2025.
Abstract The rising burden of dementia calls for high‐quality data on cognitive decline and dementia onset. The second wave of the Harmonized Diagnostic Assessment for the Longitudinal Aging Study in India (LASI‐DAD) was designed to provide longitudinal assessments of cognition and dementia in India.
Pranali Y. Khobragade   +65 more
wiley   +1 more source

Network Analyses to Explore Comorbidities Among Older Adults Living With Dementia

open access: yesJournal of the American Geriatrics Society, Volume 73, Issue 4, Page 1168-1178, April 2025.
ABSTRACT Background Older persons living with dementia (PLWD) often have multiple other chronic health conditions (i.e., comorbidities). Network analyses can describe complex profiles of chronic health conditions through graphical displays grounded in empirical data.
Samuel Quan   +5 more
wiley   +1 more source

Managing Hypercholesterolemia in Adults Older Than 75 years Without a History of Atherosclerotic Cardiovascular Disease: An Expert Clinical Consensus From the National Lipid Association and the American Geriatrics Society

open access: yesJournal of the American Geriatrics Society, EarlyView.
ABSTRACT The risk of atherosclerotic cardiovascular disease increases with advancing age. Elevated LDL‐cholesterol and non‐HDL‐cholesterol levels remain predictive of incident atherosclerotic cardiovascular events among individuals older than 75 years.
Vera Bittner   +8 more
wiley   +1 more source

Experiments with Methyl-fluoro-phosphorylcholine-inhibited Cholinesterase. [PDF]

open access: bronze, 1958
Inger Enander   +5 more
openalex   +1 more source

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