Results 121 to 130 of about 48,102 (276)

Those Debating Alzheimer Disease Modifying Therapies Should Review the Seminal JAGS Dementia Minimal Clinically Important Difference Article

Journal of the American Geriatrics Society, EarlyView.
Frank J. Molnar
wiley   +1 more source

A combined artificial intelligence–wet lab approach identifies a pivotal role of the NAD+–mitophagy axis on aging and neurodegeneration

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Emerging evidence points to a role of nicotinamide mononucleotide (NAD+) depletion and compromised mitophagy in aging and neurodegenerative diseases. We hypothesize that age‐dependent impairment of the NAD+–mitophagy axis contributes to brain aging and neurodegeneration.
Sofie Lautrup, Shu‐qin Cao, Xi Long, Bonnie Hei Man Liu, Beatriz Escobar‐Doncel, Aristide Ferrante, Johannes Frank, Tomas Schmauck‐Medina, Geoffrey Ho Duen Leung, Kristina Xiao Liang, Ning Lu, Katerina Veverova, Martin Vyhnalek, Frank W. Pun, Alex Zhavoronkov, Evandro Fei Fang   +15 more
wiley   +1 more source

Lecanemab use in Chinese patients with Alzheimer's disease: a 12‐month multicenter real‐world study

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION We evaluated lecanemab's safety and cognitive outcomes in Chinese patients with Alzheimer's disease (AD) and the utility of blood‐based biomarkers (BBMs) for treatment guidance. METHODS A multicenter, real‐world cohort enrolled 1042 patients receiving lecanemab, with 453, 359, 97 patients followed up at 3, 6, 12 months ...
Hao Wu, Qin Chen, Min Fang, Huidong Tang, Huayan Liu, Jun Liu, Jiewen Zhang, Lijun Chi, Shuai Liu, Jiawei Xin, Lumin Leng, Pan Wang, Song Chi, Yi Li, Jianwen Chen, Ligong Zhang, Jinhong Zhang, Qiang Ma, Xuezhen Wang, Xinling Meng, Jianfei Nao, Xiangqing Li, Yan Lv, Yanhong Jia, Qing Zhao, Chunyan Liu, Jinghuan Gan, Jing Zhu, Yehua Song, Huaian Li, Min Fei, Xia Guo, Jingwen Liu, Guoping Peng, Xiaochun Chen, Yong Ji   +35 more
wiley   +1 more source

OPC Poisoning and Serum Cholinesterase Levels [PDF]

, 2017
OP Poisoning is a major public health problem in the developing world. Clinical manifestations following OP poisoning can be associated with the extent of decrease of Pche. This study was undertaken to find out the relationship between OPC poisoning and
Owaise Ahmed, M
core  

Economic evaluation of population‐level dementia prevention strategies in China: informing policy and public health action

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION While it has been postulated that population‐based strategies targeting modifiable dementia risk factors are cost effective in high‐income settings, their health and economic impact in China remains unclear. METHODS A Markov model evaluated five interventions: salt substitution, smoke‐free legislation, increased tobacco tax, sugar‐
Chao Gong, Jiawei Zhang, Naaheed Mukadam, Quan Wang, Zheng Zhu, Yixin Qin, Qi Qin, Kun Yang, Xia Wei, Yi Tang, Li Yang   +10 more
wiley   +1 more source

Use of cholinesterase inhibitors in elderly patients with clinical comorbidities [PDF]

, 2008
Cholinesterase inhibitors such as donepezil, galantamine and rivastigmine are drugs indicated for treatment of hypocholinergic dementias, particularly Alzheimer's disease.
Thomaz,Débora Pereira, Cunha,Ulisses Gabriel de Vasconcelos, Marquete,Carolina Ribeiro, Balabram,Karine, Marino,Carolina Guerra   +4 more
core  

Association of Participation in the Collaborative Care Team With Behavioral and Psychological Symptoms of Dementia and Caregiver Distress

Brain and Behavior, Volume 16, Issue 8, August 2026.
The case manager–centered dementia collaborative care model was associated with reduced short‐term BPSD severity and caregiver distress. Integrating collaborative care models in long‐term care healthcare systems is recommended to better support dementia patients and caregivers.
Yu‐Hsuan Hung, Wen‐Fu Wang, Ming‐Che Chang, Yu‐Chun Tung, Kai‐Ming Jhang   +4 more
wiley   +1 more source

Decoding the role of serum cholinesterase among type 2 diabetes mellitus patients at RIMS, Ranchi – A hospital-based study

Journal of Family Medicine and Primary Care
Introduction: Diabetes mellitus (DM) type 2 is a group of conditions which is defined by persistent hyperglycemia along with various metabolic disturbances in carbohydrate, protein, and lipid metabolism. This condition is characterized by variable levels
Avijit Saha, Abha Kumari, Santosh Kumar, Abhay Kumar, Chandrakanta Munni   +4 more
doaj   +1 more source

Protective Effect of Barberry (Berberis vulgaris L.) Extract on Oxidative Stress and Behavioral Changes in Toxicity Induced by Diazinon in the Brain Tissue of Male Rats

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Diazinon (DZN) is a hazardous organophosphate pesticide that is applied to control insects, which causes oxidative damage in brain tissue. Barberry (Berberis vulgaris L.) is a plant widely used in Asia for its therapeutic properties. Objectives The present study evaluated the protective effects of B.
Razieh Parvareshi Hamrah, Elham Shiri, Ahmad Fadai, Fereshteh Mehri   +3 more
wiley   +1 more source

PharmVar GeneFocus: CYP1A2—Clinical Impact, Genetic Variation, and Updated Nomenclature

Clinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 313-323, August 2026.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human CYP1A2 gene. CYP1A2 plays a crucial role in the biotransformation of several commonly used drugs, including antipsychotics, antidepressants, anxiolytics, and methylxanthines.
Katalin Monostory, Gonzalo Villapalos Garcia, Dora Koller, Solomon Adams, Chad A. Bousman, Evangelia Eirini Tsermpini, Michelle Whirl‐Carrillo, Amy J. Turner, Volker M. Lauschke, Mohamed Nagy, Erin C. Boone, Teri E. Klein, Pablo Zubiaur, Andrea Gaedigk   +13 more
wiley   +1 more source