Results 131 to 140 of about 48,102 (276)

Design, Synthesis, and Biological Evaluation of Chiral Urea and Thiourea Derivatives as Multitarget‐Directed Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A series of novel chiral urea and thiourea compounds were designed as multitarget‐directed ligands for Alzheimer's disease and evaluated against hAChE, hBChE, and hMAO‐B, with exploratory assessment of HSD10. These chiral compounds were synthesized and fully characterized, and their enantiopurity was confirmed via HPLC.
Sule Erol Gunal, Senel Teke Tuncel, İlke Demir, İpek Baysal, Gökçen Telli, Safiye Sag Erdem, Gulberk Ucar, Michaela Hanzlova, Kamil Musilek, İlknur Dogan, Nesrin Gokhan Kelekci   +10 more
wiley   +1 more source

Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A focused library of 19 donepezil‐linked chalcones (DLCs) was efficiently synthesised through microwave‐assisted Claisen‐Schmidt condensation and subsequently profiled for their inhibitory activities against cholinesterases (AChE and BuChE) as well as monoamine oxidases (MAO‐A and MAO‐B).
Azize Kirac‐Aydin, Bishnu Prasad Pandey, Satyajit Mohanty, Rupsa Mondal, Abanish Biswas, Ashok Kumar Pattnaik, Subodh Mondal, Vinay N. Basavanakatti, Nilüfer Bayrak, Venkatesan Jayaprakash, Hoon Kim, Amaç Fatih TuYuN   +11 more
wiley   +1 more source

Design, Synthesis, X‐Ray Crystallographic Characterization, Anticholinesterase and Antioxidant Evaluation, and Molecular Modeling of Novel Dispiroindene‐Pyrrolidine Derivatives as Multifunctional Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A novel series of 5‐chloro‐N‐alkyl‐1′,1″‐dimethyl‐4′‐aryldispiro[indene‐2,3′‐pyrrolidine‐2′,3″‐indoline]−1,2″(3H)‐diones (4a–r) was rationally designed and synthesized via a one‐pot multicomponent reaction of N‐alkylated 5‐chloroisatin derivatives, 2‐(arylmethylidene)−2,3‐dihydro‐1H‐inden‐1‐ones (2a–i), and sarcosine (3).
Aisha A. Alsfouk, Riham A. El‐Shiekh, Benson M. Kariuki, Eman Sabry, Mohamed G. Abouelenein, Asmaa Saleh, Mahmoud G. A. Saleh, Aladdin M. Srour   +7 more
wiley   +1 more source

Facile Fabrication of PVA Nanofibers Decorated With Ratiometric Fluorescent Carbon Dots for Chlorpyrifos Recognition With Deep Learning

eFood, Volume 7, Issue 4, August 2026.
A ratiometric fluorescent nanosensor, comprising biomass‐derived iron‐doped carbon dots as the probe and silver nanoclusters as the internal reference, was immobilized onto a polyvinyl alcohol nanofiber membrane via electrospinning. A deep learning model, integrated into a smartphone application, accurately quantified chlorpyrifos by analyzing images ...
Weirui Fang, Xiaoyi Zhu, Xingyu Rong, Zhen Wang, Manjun Du, Shiyu Liu, KangJu Lee, Yaowen Liu   +7 more
wiley   +1 more source

Hepatectomy and plasma cholinesterase evolution [PDF]

, 1997
The article provides original results regarding the evolution of plasma cholinesterase in the postoperative state aftre liver resection, with clinical and biochemical ...
Giovannini, Ivo, Chiarla, Carlo, Giuliante, Felice, Vellone, Maria, Nuzzo, Gennaro, Lemmo, Gianfranco, Boldrini, Giuseppe   +6 more
core  

Investigating the Antidiabetic Effects of Calotropis procera: Preclinical Assessment

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Calotropis Procera In vitro/Diabetic rodent model Improved β‐cell function, reduced hepatic gluconeogenesis antioxidant activity. ABSTRACT Diabetes mellitus (DM) is a metabolic disease characterized by persistent hyperglycemia, oxidative stress, and inflammation, often leading to severe complications.
Yu‐Cheng Kuo, Musa I. Ajibola, Halimat Y. Lukman, Bashir Lawal, Lung‐Ching Chen, Sheng‐Liang Huang, Olawale David Ajayi, Sunday Amos Onikanni, Saheed Sabiu, Leandro Miranda‐Alves, Hsu‐Shan Huang   +10 more
wiley   +1 more source

Cholinesterase Activity of the Motor Endplate in Rat Intercostal Muscle [PDF]

Cholinesterase activity was localized solely in the motor endplate of the membrane in rate intercostal muscle. The diameter of rat motor endplates in the gradient dimension was 31.9 micrometers. The cholinesterase activity per unit protein of the soluble
Fuji, Masafumi, Namba, Tatsuji
core  

Neuromodulatory subcortical systems in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Alexander J. Ehrenberg, Neus Falgàs, Heidi I. L. Jacobs, Lea T. Grinberg, ISTAART NSS PIA Executive Committee Chairs, 2020–2028   +5 more
wiley   +1 more source

Phytochemical Characterization and Bioactive Potential of Stachys germanica L.: LC–MS/MS Profiling and Multi‐Target Biological Activities

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
The 80% ethanolic extract of Stachys germanica L. exhibited a phenolic‐rich phytochemical profile characterized by chlorogenic acid, naringin, luteolin, and kaempferol. The extract demonstrated notable antioxidant capacity, selective tyrosinase and α‐glucosidase inhibition, and significant antibacterial activity against Acinetobacter baumannii ATCC ...
Gözde Gülin İnan, Derya Doğanay, Yiğit İnan, Selin Akyüz‐Çetin, Neşet Neşetoğlu, İbrahim Daniş, Esra Mertoğlu, Durişehvar Özer Ünal, Gokhan Zengin   +8 more
wiley   +1 more source

Reactions of Methamidophos with Mammalian Cholinesterase [PDF]

Civil Aerospace Medical Institute1978PDFTech ReportRobinson C.P.Beiergrohslein D.Smith P.WCrane C.R.Civil Aerospace Medical InstituteUnited StatesInsecticidesPoisonsPhysiological aspectsMammalsBrainStomachBlood analysisToxicityNervous systemLaboratory ...

core