Plant Terpenoids as the Promising Source of Cholinesterase Inhibitors for Anti-AD Therapy
Biology, 2022 Plant-derived terpenes are the prolific source of modern drugs such as taxol, chloroquine and artemisinin, which are widely used to treat cancer and malaria infections.
Shereen Lai Shi Min +5 more
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Use of Inhibitors in Cholinesterase Histochemistry [PDF]
Nature, 1965 PRESENT-DAY histochemical methods for demonstrating cholinesterases require the use of inhibitors in order to distinguish between acetyl- (that is, true, or specific) cholinesterase (AChE) and butyryl- (non-specific) cholinesterase (ChE). The histochemical technique determines AChE and ChE together, so that if either enzyme is inhibited without the ...
P. C. Diegenbach
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Potential revival of cholinesterase inhibitors as drugs in veterinary medicine [PDF]
Frontiers in Veterinary Science, 2023 The cholinergic system is involved in the regulation of all organ systems and has acetylcholine (ACh) as almost its only neurotransmitter. Any substance is called cholinergic if it can alter the action of acetylcholine. Cholinesterases (ChEs) are enzymes
Neža Žnidaršič +3 more
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Cholinesterase Inhibitors: Structure of Eserine [PDF]
Nature, 1973 ESERINE (physostigmine) was first isolated from the Calabar bean in the latter half of the last century1, but it was not until much later that its activity on the heart was demonstrated to be due to inhibition of acetylcholinesterase2,3. It is one of the few compounds that are equally active as inhibitors of both true and pseudo-cholinesterase and has ...
Trevor J. Petcher, Peter Pauling
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Cholinesterase inhibitors: drugs looking for a disease?
PLoS Medicine, 2006 Maggini and colleagues examine the evidence on cholinesterase inhibitors for treating dementia. "What seemed a biologically plausible intervention," they say, "has not led to a proven, real improvement in patients' well-being."
Marina Maggini +2 more
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Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review [PDF]
Brain SciencesIntroduction: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline, primarily due to dysfunction of acetylcholine caused by acetylcholinesterase and butyrylcholinesterase.
Maryam N. ALNasser +3 more
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Proline-Based Carbamates as Cholinesterase Inhibitors [PDF]
Molecules, 2017 Series of twenty-five benzyl (2S)-2-(arylcarbamoyl)pyrrolidine-1-carboxylates was prepared and completely characterized. All the compounds were tested for their in vitro ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and
Hana Pizova +10 more
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Two selective inhibitors of cholinesterase [PDF]
Biochemical Journal, 1953 L. Austin, W.K. Berry
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A New Class of Benzo[b]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies [PDF]
MoleculesIn this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases (ChE) and the viability of SH-SY5Y cells have been evaluated.
Giovanna Lucia Delogu +6 more
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Can Marine Products Improve Alzheimer’s Disease [PDF]
Journal of Sciences, Islamic Republic of Iran, 2020 Alzheimer's disease is an irreversible chronic neurodegenerative disease which is the most common cause of dementia among older adults. According to amyloid hypothesis, cholin neurotransmitters have important roles in CNS memory function, therefore ...
Hamid-Reza Adhami, Paria Sharafi
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