Results 1 to 10 of about 3,332,447 (220)

Plant Terpenoids as the Promising Source of Cholinesterase Inhibitors for Anti-AD Therapy

Biology, 2022
Plant-derived terpenes are the prolific source of modern drugs such as taxol, chloroquine and artemisinin, which are widely used to treat cancer and malaria infections.
Shereen Lai Shi Min, Sook Yee Liew, Nelson Jeng Yeou Chear, Bey Hing Goh, Wen-Nee Tan, Kooi Yeong Khaw   +5 more
doaj   +2 more sources

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review [PDF]

Brain Sciences
Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline, primarily due to dysfunction of acetylcholine caused by acetylcholinesterase and butyrylcholinesterase.
Maryam N. ALNasser, Ghadir M. Alboraiy, Eman M. Alsowig, Fatimah M. Alqattan   +3 more
doaj   +2 more sources

Adverse Effects of Cholinesterase Inhibitors in Dementia, According to the Pharmacovigilance Databases of the United-States and Canada.

PLoS ONE, 2015
This survey analyzes two national pharmacovigilance databases in order to determine the major adverse reactions observed with the use of cholinesterase inhibitors in dementia.
Thibault B Ali, Thomas R Schleret, Brian M Reilly, Winston Yuchen Chen, Ruben Abagyan   +4 more
doaj   +2 more sources

Proline-Based Carbamates as Cholinesterase Inhibitors [PDF]

Molecules, 2017
Series of twenty-five benzyl (2S)-2-(arylcarbamoyl)pyrrolidine-1-carboxylates was prepared and completely characterized. All the compounds were tested for their in vitro ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and
Hana Pizova, Marketa Havelkova, Pavel Bobal, Sarka Stepankova, Tereza Kauerova, Andrzej Bak, Peter Kollar, Violetta Kozik, Michal Oravec, Ales Imramovsky, Josef Jampilek   +10 more
doaj   +5 more sources

A New Class of Benzo[b]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies [PDF]

Molecules
In this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases (ChE) and the viability of SH-SY5Y cells have been evaluated.
Giovanna Lucia Delogu, Michela Begala, Maria João Matos, Davide Crucitti, Valeria Sogos, Benedetta Era, Antonella Fais   +6 more
doaj   +2 more sources

Long-term Effects of Cholinesterase Inhibitors on Cognitive Decline and Mortality

Neurology, 2021
Objective To investigate whether cholinesterase inhibitors (ChEIs) are associated with slower cognitive decline in Alzheimer dementia and decreased risk of severe dementia or death.
Hong Xu, S. García-Ptacek, L. Jönsson, A. Wimo, P. Nordström, M. Eriksdotter   +5 more
semanticscholar   +1 more source

Can Marine Products Improve Alzheimer’s Disease [PDF]

Journal of Sciences, Islamic Republic of Iran, 2020
Alzheimer's disease is an irreversible chronic neurodegenerative disease which is the most common cause of dementia among older adults. According to amyloid hypothesis, cholin neurotransmitters have important roles in CNS memory function, therefore ...
Hamid-Reza Adhami, Paria Sharafi
doaj   +1 more source

Potential revival of cholinesterase inhibitors as drugs in veterinary medicine

Frontiers in Veterinary Science, 2023
The cholinergic system is involved in the regulation of all organ systems and has acetylcholine (ACh) as almost its only neurotransmitter. Any substance is called cholinergic if it can alter the action of acetylcholine. Cholinesterases (ChEs) are enzymes
Neža Žnidaršič, Malan Štrbenc, Neža Grgurevič, Tomaž Snoj   +3 more
doaj   +1 more source

Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias.

Ideggyógyászati Szemle, 2021
In aging societies, the morbidity and mortality of dementia is increasing at a significant rate, thereby imposing burden on healthcare, economy and the society as well.
N. Balázs, D. Bereczki, T. Kovács
semanticscholar   +1 more source

Withdrawal or continuation of cholinesterase inhibitors or memantine or both, in people with dementia.

Cochrane Database of Systematic Reviews, 2021
BACKGROUND Dementia is a progressive syndrome characterised by deterioration in memory, thinking and behaviour, and by impaired ability to perform daily activities. Two classes of drug - cholinesterase inhibitors (donepezil, galantamine and rivastigmine)
C. Parsons, Wei Yin Lim, Clement Loy, B. McGuinness, P. Passmore, S. Ward, C. Hughes   +6 more
semanticscholar   +1 more source