Results 131 to 140 of about 2,781,261 (274)

The Application of Polymeric Nanoparticles as Drug Delivery Carriers to Cells in Neurodegenerative Diseases

Cell Proliferation, EarlyView.
Polymeric nanoparticles represent promising drug (gene) delivery carriers to the brain due to their unique advantages to facilitate the penetration of blood–brain barrier and endocytosis of neuronal cells in neurodegenerative diseases. ABSTRACT In spite of great advances in modern medicine, there are a few effective strategies for the treatment of ...
Lian Jin, Libo Nie, Yan Deng, Ghulam Jilany Khana, Nongyue He   +4 more
wiley   +1 more source

Characterization of binding of antipsychotics to muscarinic receptors using mouse cerebral cortex

Journal of Pharmacological Sciences, 2019
Antipsychotics are often the first-line treatment for behavioral and psychological symptoms of dementia. However, the potential anticholinergic effects of antipsychotics could counteract the therapeutic effects of cholinesterase inhibitors used to treat ...
Keisuke Obara, Saki Horiguchi, Toma Shimada, Takumi Ikarashi, Fumiko Yamaki, Kazuhiro Matsuo, Takashi Yoshio, Yoshio Tanaka   +7 more
doaj  

Acute and persistent changes in neural oscillatory activity predict development of epilepsy following acute organophosphate intoxication in adult rats

Epilepsia, Volume 66, Issue 4, Page 1329-1342, April 2025.
Abstract Objective Acute organophosphate (OP) intoxication affects a significant number of individuals worldwide. Those who survive OP‐induced cholinergic crisis, which includes status epilepticus, often develop neurological morbidities. Here, we provide a rigorous characterization of the acute and delayed electrophysiological responses to OP ...
Jeremy A. MacMahon, Peter M. Andrew, Ali Izadi, Donald A. Bruun, Naomi H. Saito, Daniel J. Tancredi, Amy Brooks‐Kayal, Pamela J. Lein, Gene G. Gurkoff   +8 more
wiley   +1 more source

To Explore the Potential Inhibitors against Multitarget Proteins of COVID 19 using In Silico Study [PDF]

arXiv
The global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many efforts to find the optimal solution of this pandemic. Progressively, drug repurposing is an emergent and powerful strategy with saving cost, time, and labor ...
arxiv  

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Wolfgang Löscher, Dorothée Kasteleijn‐Nolst Trenité   +1 more
wiley   +1 more source

Is Australia ready for the rollout of amyloid‐targeting therapies for Alzheimer's disease? Results from a national survey characterising current infrastructure capability, workforce and training needs of memory and cognition clinics

Internal Medicine Journal, EarlyView.
Abstract Background New amyloid‐targeting monoclonal antibody (mAb) therapies for Alzheimer's disease (AD) are currently under review by the Therapeutic Goods Administration for use in Australia. Aims To determine the infrastructure, workforce and training needs of Australian memory and cognition clinics in order to characterise health system ...
Johannes C. Michaelian, Christopher C. Rowe, Susan E. Kurrle, Constance Dimity Pond, Michael Woodward, Sharon L. Naismith   +5 more
wiley   +1 more source

Design and methodology of the harmonized diagnostic assessment of dementia for the longitudinal aging study in India: Wave 2

Journal of the American Geriatrics Society, Volume 73, Issue 3, Page 685-696, March 2025.
Abstract The rising burden of dementia calls for high‐quality data on cognitive decline and dementia onset. The second wave of the Harmonized Diagnostic Assessment for the Longitudinal Aging Study in India (LASI‐DAD) was designed to provide longitudinal assessments of cognition and dementia in India.
Pranali Y. Khobragade, Sarah Petrosyan, Sharmistha Dey, A. B. Dey, Jinkook Lee, on behalf of the LASI‐DAD Authorship Team, Pranali Y. Khobragade, Sarah Petrosyan, Albert Weerman, Peifeng Hu, Alden L. Gross, Joyita Banerjee, Sandy Chien, Marco Angrisani, Sara D. Adar, Leon Aksman, Niranjan Khandelwal, Anushikha Dhankhar, Harrshita Vishwakarrma, Swaroop Bhatankar, Swati Bajpai, Istikhar Ali, Masroor Anwar, Abhishek Gupta, Clarice Myers, Alka Mohan Chutani, Claire McEvoy, Danielle E. Logan, Kirsten Lynch, Ziqi Zhou, Emma Nichols, Rajeev Aravindakshan, Sankha Subhra Chakrabarti, Madhumita Priyadarshini Das, Karishma De, Minakshi Dhar, Gevesh C. Dewangan, Monica Gupta, Umar Hafiz Khan, Vishakha Jain, John P. John, Ravi Kirti, Arun Kokane, Sarabmeet Singh Lehl, Rashmi R. Mohanty, Vinay Pandit, Chhaya Rajguru, Durgesh Prasad Sahoo, Lalit Sankhe, M. Sukumar, Arunansu Talukdar, Venugopalan Gunasekaran, Joshua R. Ehrich, Elissa S. Epel, David Flood, T. V. Sekher, David E. Bloom, Kenneth M. Langa, Palanimuthu T. Sivakumar, Mathew Varghese, Mary Ganguli, Bharat Thyagarajan, Eileen M. Crimmins, Sharmistha Dey, A. B. Dey, Jinkook Lee   +65 more
wiley   +1 more source

Network Analyses to Explore Comorbidities Among Older Adults Living With Dementia

Journal of the American Geriatrics Society, Volume 73, Issue 4, Page 1168-1178, April 2025.
ABSTRACT Background Older persons living with dementia (PLWD) often have multiple other chronic health conditions (i.e., comorbidities). Network analyses can describe complex profiles of chronic health conditions through graphical displays grounded in empirical data.
Samuel Quan, Barret A. Monchka, Philip D. St. John, Malcolm B. Doupe, Maxime Turgeon, Lisa M. Lix   +5 more
wiley   +1 more source

Managing Hypercholesterolemia in Adults Older Than 75 years Without a History of Atherosclerotic Cardiovascular Disease: An Expert Clinical Consensus From the National Lipid Association and the American Geriatrics Society

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The risk of atherosclerotic cardiovascular disease increases with advancing age. Elevated LDL‐cholesterol and non‐HDL‐cholesterol levels remain predictive of incident atherosclerotic cardiovascular events among individuals older than 75 years.
Vera Bittner, Sunny A. Linnebur, Dave L. Dixon, Daniel E. Forman, Ariel R. Green, Terry A. Jacobson, Ariela R. Orkaby, Joseph J. Saseen, Salim S. Virani   +8 more
wiley   +1 more source

Consumption trends for specific drugs used to treat dementia in the region of Madrid (Spain) from 2002 to 2012

Neurología (English Edition), 2015
Introduction: Analysing drug consumption in large population groups lets us observe consumption trends and compare them between different settings. Objective: To analyse the time trends for consumption and costs of specific drugs used to treat dementia ...
M.C. de Hoyos-Alonso, E. Tapias-Merino, C.M. Meseguer Barros, M. Sánchez-Martínez, A. Otero   +4 more
doaj