Adverse Effects of Cholinesterase Inhibitors in Dementia, According to the Pharmacovigilance Databases of the United-States and Canada. [PDF]
This survey analyzes two national pharmacovigilance databases in order to determine the major adverse reactions observed with the use of cholinesterase inhibitors in dementia.
Thibault B Ali +4 more
doaj +6 more sources
Potential revival of cholinesterase inhibitors as drugs in veterinary medicine [PDF]
The cholinergic system is involved in the regulation of all organ systems and has acetylcholine (ACh) as almost its only neurotransmitter. Any substance is called cholinergic if it can alter the action of acetylcholine. Cholinesterases (ChEs) are enzymes
Neža Žnidaršič +3 more
doaj +2 more sources
Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review [PDF]
Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline, primarily due to dysfunction of acetylcholine caused by acetylcholinesterase and butyrylcholinesterase.
Maryam N. ALNasser +3 more
doaj +2 more sources
Proline-Based Carbamates as Cholinesterase Inhibitors [PDF]
Series of twenty-five benzyl (2S)-2-(arylcarbamoyl)pyrrolidine-1-carboxylates was prepared and completely characterized. All the compounds were tested for their in vitro ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and
Hana Pizova +10 more
doaj +5 more sources
A New Class of Benzo[b]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies [PDF]
In this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases (ChE) and the viability of SH-SY5Y cells have been evaluated.
Giovanna Lucia Delogu +6 more
doaj +2 more sources
Can Marine Products Improve Alzheimer’s Disease [PDF]
Alzheimer's disease is an irreversible chronic neurodegenerative disease which is the most common cause of dementia among older adults. According to amyloid hypothesis, cholin neurotransmitters have important roles in CNS memory function, therefore ...
Hamid-Reza Adhami, Paria Sharafi
doaj +1 more source
Plant Terpenoids as the Promising Source of Cholinesterase Inhibitors for Anti-AD Therapy
Plant-derived terpenes are the prolific source of modern drugs such as taxol, chloroquine and artemisinin, which are widely used to treat cancer and malaria infections.
Shereen Lai Shi Min +5 more
doaj +1 more source
Cholinesterase inhibitors and hospitalization for bradycardia: a population-based study. [PDF]
BACKGROUND: Cholinesterase inhibitors are commonly used to treat dementia. These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients.
Laura Y Park-Wyllie +5 more
doaj +1 more source
Association of cognitive enhancers and incident seizure risk in dementia: a population-based study
Background Although individuals with dementia have a high risk of developing seizures, whether seizures are associated with cholinesterase inhibitors, which are commonly prescribed to treat individuals with dementia, remains unknown.
Junghee Ha +5 more
doaj +1 more source
As an important source of cholinesterase inhibitors, alkaloids in natural products have high potential value in terms of exerting pharmacological activities.
Pengfei Yu +8 more
doaj +1 more source

