Results 11 to 20 of about 2,781,261 (274)
Proline-Based Carbamates as Cholinesterase Inhibitors [PDF]
Molecules, 2017 Series of twenty-five benzyl (2S)-2-(arylcarbamoyl)pyrrolidine-1-carboxylates was prepared and completely characterized. All the compounds were tested for their in vitro ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and
Hana Pizova +10 more
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Two selective inhibitors of cholinesterase [PDF]
Biochemical Journal, 1953 L. Austin, W.K. Berry
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Cholinesterase inhibitors: drugs looking for a disease?
PLoS Medicine, 2006 Maggini and colleagues examine the evidence on cholinesterase inhibitors for treating dementia. "What seemed a biologically plausible intervention," they say, "has not led to a proven, real improvement in patients' well-being."
Marina Maggini +2 more
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Use of Inhibitors in Cholinesterase Histochemistry [PDF]
Nature, 1965 PRESENT-DAY histochemical methods for demonstrating cholinesterases require the use of inhibitors in order to distinguish between acetyl- (that is, true, or specific) cholinesterase (AChE) and butyryl- (non-specific) cholinesterase (ChE). The histochemical technique determines AChE and ChE together, so that if either enzyme is inhibited without the ...
P. C. Diegenbach
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Cholinesterase Inhibitors: Structure of Eserine [PDF]
Nature, 1973 ESERINE (physostigmine) was first isolated from the Calabar bean in the latter half of the last century1, but it was not until much later that its activity on the heart was demonstrated to be due to inhibition of acetylcholinesterase2,3. It is one of the few compounds that are equally active as inhibitors of both true and pseudo-cholinesterase and has ...
Trevor J. Petcher, Peter Pauling
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Cholinesterase inhibitors and hospitalization for bradycardia: a population-based study. [PDF]
PLoS Medicine, 2009 BACKGROUND: Cholinesterase inhibitors are commonly used to treat dementia. These drugs enhance the effects of acetylcholine, and reports suggest they may precipitate bradycardia in some patients.
Laura Y Park-Wyllie +5 more
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Cholinesterase inhibitors for delirium [PDF]
Cochrane Database of Systematic Reviews, 2005 Delirium is now the preferred term to describe acute confusional states. It is experienced by 10 to 30% of all hospital inpatients. Delirium is potentially reversible and is related to several adverse outcomes, including increased hospital length of stay, poor functional status, persistent cognitive impairment, need for institutional care and probably ...
Ross Overshott +2 more
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Association of cognitive enhancers and incident seizure risk in dementia: a population-based study
BMC Geriatrics, 2022 Background Although individuals with dementia have a high risk of developing seizures, whether seizures are associated with cholinesterase inhibitors, which are commonly prescribed to treat individuals with dementia, remains unknown.
Junghee Ha +5 more
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Molecules, 2022 As an important source of cholinesterase inhibitors, alkaloids in natural products have high potential value in terms of exerting pharmacological activities.
Pengfei Yu +8 more
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Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source