Benzene-1,3-diol derivatives as the inhibitors of butyrylcholinesterase: An emergent target of Alzheimer’s disease [PDF]
Journal of the Serbian Chemical Society, 2022 Molecular docking is a powerful and significant approach for the identification of lead molecules on the basis of virtual screening. With it a large number of compounds can be tested and based on the scoring function and ranking, the conclusion can be ...
Dongliang Yin +7 more
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Учёные записки Казанского университета: Серия Естественные науки, 2021 Cholinesterase inhibitors have been the subject of many studies aimed at developing an effective treatment for various cognitive disorders. Therefore, studying cholinesterases and elucidating the mechanism of their interaction with ligands provide a ...
A.R. Mukhametgalieva +3 more
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An investigation of acute effects at various doses of malathion on glucose homeostasis and insulin resistance in rat liver, pancreas and serum [PDF]
, 2020 Objective. This study investigates acute effects of various doses of Malathion on glucose homeostasis and insulin resistance in rat. Methods. Rats were randomly divided into four groups of 6 animals each. Corn oil was given orally to Group 1.
Ekremoğlu, Murat +4 more
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Beyond Cholinesterase Inhibition. Anti-Inflammatory Role and Pharmacological Profile of Current Drug Therapy for Alzheimer's Disease [PDF]
, 2016 Inflammation is a common response of an individual against either exogenous or endogenous damage. The role of inflammation and of inflammatory cells recently emerged also in the pathogenesis of neurodegenerative disorders. Experimental evidences show how
GIUBILEI, Franco
core +1 more source
Frontiers in Marine Science, 2021 The search for effective yet environmentally friendly strategies to prevent marine biofouling is hampered by the large taxonomic diversity amongst fouling organisms and a lack of well-defined conserved molecular targets.
Homayon John Arabshahi +7 more
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Pyridostigmine in pediatric Intestinal pseudo-obstruction. case report of a 2-year old girl and literature review [PDF]
, 2019 Pediatric chronic intestinal pseudo-obstruction is a rare disorder characterized by a severe impairment of gastrointestinal motility leading to intestinal obstruction symptoms in the absence of mechanical causes.
Caló, Girolamo +8 more
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Dysregulated homeostasis of acetylcholine levels in immune cells of RR-multiple sclerosis patients [PDF]
, 2016 Multiple sclerosis (MS) is characterized by pro-inflammatory cytokine production. Acetylcholine (ACh) contributes to the modulation of central and peripheral inflammation.
Biagioni, Stefano +11 more
core +2 more sources
Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources
Molecules, 2021 Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world.
Alfred Ngenge Tamfu +4 more
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Comptes Rendus. Chimie, 2022 In our previous research, some screened 1,3-thiazole fragments were found to be potent by inhibiting LPS-induced TNF$\alpha $ and IL-8 release with IC50 values in the $\mu $M range without cytotoxic activity.
Modrić, Marina +7 more
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The acetylcholinesterase as indicative of intoxication for pesticide in farmers of conventional and organic cultivation [PDF]
Brazilian Journal of Biology, 2020 In this sense the objective of assessing the levels of pesticide poisoning in rural farmers of San Sebastian and take AL, using acetylcholinesterase enzymes Erythrocyte and plasma as biological indicator of intoxication.
H. H. F. Alves +9 more
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