Results 21 to 30 of about 2,823,581 (316)
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source
An examination of three prescribing cascades in a cohort of older adults with dementia
BMC Geriatrics, 2021 Background Prescribing cascades are a source of inappropriate prescribing for older adults with dementia. We aimed to study three prescribing cascades in older Nova Scotians with dementia using administrative databases.
Shanna C. Trenaman +3 more
doaj +1 more source
Benzene-1,3-diol derivatives as the inhibitors of butyrylcholinesterase: An emergent target of Alzheimer’s disease [PDF]
Journal of the Serbian Chemical Society, 2022 Molecular docking is a powerful and significant approach for the identification of lead molecules on the basis of virtual screening. With it a large number of compounds can be tested and based on the scoring function and ranking, the conclusion can be ...
Dongliang Yin +7 more
doaj +1 more source
Учёные записки Казанского университета: Серия Естественные науки, 2021 Cholinesterase inhibitors have been the subject of many studies aimed at developing an effective treatment for various cognitive disorders. Therefore, studying cholinesterases and elucidating the mechanism of their interaction with ligands provide a ...
A.R. Mukhametgalieva +3 more
doaj +1 more source
Cholinesterase inhibitors as Alzheimer's therapeutics
Molecular Medicine Reports, 2019 Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic syndrome of the central nervous system that causes a decline in cognitive function and language ability.
K. Sharma
semanticscholar +1 more source
Frontiers in Marine Science, 2021 The search for effective yet environmentally friendly strategies to prevent marine biofouling is hampered by the large taxonomic diversity amongst fouling organisms and a lack of well-defined conserved molecular targets.
Homayon John Arabshahi +7 more
doaj +1 more source
Non-Alkaloid Cholinesterase Inhibitory Compounds from Natural Sources
Molecules, 2021 Alzheimer’s disease (AD) is a severe neurodegenerative disorder of different brain regions accompanied by distresses and affecting more than 25 million people in the world.
Alfred Ngenge Tamfu +4 more
doaj +1 more source
The acetylcholinesterase as indicative of intoxication for pesticide in farmers of conventional and organic cultivation [PDF]
Brazilian Journal of Biology, 2020 In this sense the objective of assessing the levels of pesticide poisoning in rural farmers of San Sebastian and take AL, using acetylcholinesterase enzymes Erythrocyte and plasma as biological indicator of intoxication.
H. H. F. Alves +9 more
doaj +1 more source
Comptes Rendus. Chimie, 2022 In our previous research, some screened 1,3-thiazole fragments were found to be potent by inhibiting LPS-induced TNF$\alpha $ and IL-8 release with IC50 values in the $\mu $M range without cytotoxic activity.
Modrić, Marina +7 more
doaj +1 more source
Understanding Alzheimer disease
South African Family Practice, 2019 Alzheimer disease (AD) is a neurodegenerative disorder with an uncertain pathogenesis. It is characterised by symptoms of memory impairment, executive dysfunction and visuospatial impairment.
M. Vally, F. Kathrada
doaj +1 more source