Results 71 to 80 of about 42,628 (216)
Transcriptional Profiles for Glutamate Transporters Reveal Differences Between Organophosphates but Similarities with Unrelated Neurotoxicants [PDF]
, 2010 The developmental neurotoxicity of organophosphates involves mechanisms other than their shared property as cholinesterase inhibitors, among which are excitotoxicity and oxidative stress.
Lobner, Doug +2 more
core +2 more sources
Movement Disorders Clinical Practice, EarlyView.Abstract Background Visual hallucinations (VH) and mild cognitive impairment (MCI) often co‐occur in Parkinson's Disease (PD). Each symptom in isolation is associated with cholinergic basal forebrain (BF) atrophy. However, it is unclear whether BF integrity relates to one symptom preferentially or to their co‐occurrence, and whether this relationship ...
Sabrina M. Adamo +6 more
wiley +1 more source
Neurología (English Edition), 2015 Introduction: Analysing drug consumption in large population groups lets us observe consumption trends and compare them between different settings. Objective: To analyse the time trends for consumption and costs of specific drugs used to treat dementia ...
M.C. de Hoyos-Alonso +4 more
doaj +1 more source
Meeting report : Neuropathology and Neuropharmacology of Monoaminergic systems [PDF]
, 2014 The third EU COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” Annual Conference entitled “Neuropathology and ...
De Deurwaerdere, Philippe +1 more
core +1 more source
Clinical and Radiological Evolution of Idiopathic Normal Pressure Hydrocephalus: A Critical Review
Movement Disorders Clinical Practice, EarlyView.Abstract Background The pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) remains poorly understood. While it is commonly accepted that iNPH has an insidious onset, little is known about its preclinical and early stages and its development over time.
David Campo‐Caballero +6 more
wiley +1 more source
Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis. [PDF]
, 2015 OBJECTIVE: The authors examined research on effects, costs, and patient and caregiver views of pharmacological management strategies for Lewy body dementia.
Cambridge, Victoria +9 more
core +2 more sources
Is anti-cholinesterase therapy of Alzheimer's disease delaying progression? [PDF]
, 2018 During the last decade, a systematic effort to develop a pharmacological treatment for Alzheimer's disease (AD) resulted in three drugs being registered for the first time in the US and Europe.
Giacobini, E.
core
Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies
Movement Disorders, EarlyView.Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer’s agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic site (
Ana I. Ahuja-Casarín +9 more
doaj +1 more source
Rapid Structural Analysis of Natural Products Using MicroED
Small, EarlyView.The cryoEM method, MicroED used for rapid analysis and structure determination of natural products that remained unattainable by other structural biology methods ABSTRACT Structural analysis of natural products remains challenging due to their inherent complexity and limited availability.
Jieye Lin +3 more
wiley +1 more source