Results 81 to 90 of about 2,781,261 (274)

Lewy Body Dementia Research in Latin America: A Scoping Review

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Dementia research in Latin America (LA) has primarily focused on Alzheimer's Disease and Frontotemporal Dementia, while Lewy body dementia (LBD) has been largely forgotten. Objective We aimed to review the available evidence on LBD in LA, offering a comprehensive perspective for understanding the lack of reports and the unique ...
Carlos Cano‐Gutiérrez, Salomón Salazar‐Londoño, Felipe Botero‐Rodriguez, Salomón Páez‐García, Salomón Giraldo, José Manuel Santacruz‐Escudero, Dag Aarsland, Miguel Germán Borda, on behalf of COL‐DLB, Felipe Botero‐Rodriguez, Miguel Germán Borda, Omar Buritica, Catalina Cerquera‐Cleves, Maria Camila Gonzalez, Elkin Garcia‐Cifuentes, Alberto Jaramillo‐Jimenez, David Aguillon, Yamile Bocanegra, Beatriz Elena Munoz‐Ospina, Carlos Alberto Cano‐Gutierrez, Carlos Tobón, Hernando Santamaría‐García, José Manuel Santacruz‐Escudero, Dag Aarsland, Jorge Orozco, Salomon Salazar‐Londoño, Luis Carlos Venegas‐Sanabria, Salomón Páez‐García, Francisco Lopera, Juan Camilo Castro, Patrick Verhelst Forero, Alexandra Ferreiròs   +31 more
wiley   +1 more source

Cholinesterase inhibitors for the treatment of delirium in non-ICU settings.

Cochrane Database of Systematic Reviews, 2017
BACKGROUND Delirium is a common clinical syndrome defined as alterations in attention with an additional disturbance in cognition or perception, which develop over a short period of time and tend to fluctuate during the course of the episode. Delirium is
Ailan Yu, Shanshan Wu, Zong-wang Zhang, T. Dening, Sai Zhao, G. Pinner, J. Xia, Daogui Yang   +7 more
semanticscholar   +1 more source

Speech Differences between Multiple System Atrophy and Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Delineation of Parkinson's disease (PD) from multiple system atrophy (MSA) can be challenging in early disease stages. Speech characteristics have been studied as digital biomarkers in PD and ataxias. Currently, data on speech in MSA is limited.
Tom Hähnel, Anna Nemitz, Katja Schön, Luise Berger, Annemarie Vogel, Doreen Gruber, Nils Schnalke, Stefan Bräuer, Björn H. Falkenburger, Florin Gandor   +9 more
wiley   +1 more source

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review

Brain Sciences
Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline, primarily due to dysfunction of acetylcholine caused by acetylcholinesterase and butyrylcholinesterase.
Maryam N. ALNasser, Ghadir M. Alboraiy, Eman M. Alsowig, Fatimah M. Alqattan   +3 more
doaj   +1 more source

Novel N‐allyl/propargyl tetrahydroquinolines: Synthesis via Three‐component Cationic Imino Diels–Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors

Chemical Biology and Drug Design, 2016
New N‐allyl/propargyl 4‐substituted 1,2,3,4‐tetrahydroquinolines derivatives were efficiently synthesized using acid‐catalyzed three components cationic imino Diels–Alder reaction (70–95%).
Yeray A. Rodríguez, Margarita Gutiérrez, David Ramírez, Jans H. Alzate-Morales, Cristian C. Bernal, Fausto M. Güiza, Arnold R. Romero Bohórquez   +6 more
semanticscholar   +1 more source

Prediction of 5-hydroxytryptamine Transporter Inhibitor based on Machine Learning [PDF]

arXiv, 2019
In patients with depression, the use of 5-HT reuptake inhibitors can improve the condition. Topological fingerprints, ECFP4, and molecular descriptors were used. Some SERT and small molecules combined prediction models were established by using 5 machine learning methods. We selected the higher accuracy models(RF, SVM, LR) in five-fold cross-validation
arxiv  

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source

Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors

PeerJ, 2016
Inhibition of acetylcholinesterase (AChE) using small molecules is still one of the most successful therapeutic strategies in the treatment of Alzheimer’s disease (AD).
Yao Chen, Yaoyao Bian, Yuan Sun, Chen Kang, Sheng Yu, Tingming Fu, Wei Li, Yuqiong Pei, Haopeng Sun   +8 more
semanticscholar   +1 more source

Cortical Effects of Dopamine Replacement Account for Clinical Response Variability in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Individual variability in clinical response to dopamine replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources of such interindividual differences is necessary to personalize DRT prescribing, inform future clinical ...
Alex I. Wiesman, Mikkel C. Vinding, Panagiota Tsitsi, Per Svenningsson, Josefine Waldthaler, Daniel Lundqvist   +5 more
wiley   +1 more source

Cholinesterase inhibitors for Parkinson’s disease-related visual hallucinations unresponsive to atypical antipsychotics

Archives of Medical Science, 2007
Introduction: Considering lack of accepted guideline in cases of Parkinson’s disease-related visual hallucinations with poor response or intolerance to antipsychotics, and their possible cholinergic pathogenesis, the trial with cholinesterase inhibitors ...
Tomasz Sobow
doaj