Results 81 to 90 of about 2,823,581 (316)

Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors

PeerJ, 2016
Inhibition of acetylcholinesterase (AChE) using small molecules is still one of the most successful therapeutic strategies in the treatment of Alzheimer’s disease (AD).
Yao Chen, Yaoyao Bian, Yuan Sun, Chen Kang, Sheng Yu, Tingming Fu, Wei Li, Yuqiong Pei, Haopeng Sun   +8 more
semanticscholar   +1 more source

Cortical Effects of Dopamine Replacement Account for Clinical Response Variability in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Individual variability in clinical response to dopamine replacement therapy (DRT) is a key barrier to efficacious treatment for patients with Parkinson's disease (PD). A better understanding of the neurobiological sources of such interindividual differences is necessary to personalize DRT prescribing, inform future clinical ...
Alex I. Wiesman, Mikkel C. Vinding, Panagiota Tsitsi, Per Svenningsson, Josefine Waldthaler, Daniel Lundqvist   +5 more
wiley   +1 more source

Positron Emission Tomography Imaging in Clinical Trials for Parkinson's Disease: Applications of Metabolic Brain Network Approach

Movement Disorders, EarlyView.
ABSTRACT Neuroimaging with positron emission tomography (PET) has been instrumental in elucidating neurobiological mechanisms behind therapeutical trials in Parkinson's disease (PD). A variety of medical and neurosurgical interventions have been evaluated using many radioligands that reveal molecular basis for target engagement and brain responses in ...
Vijay Dhawan, Shichun Peng, Phoebe G. Spetsieris, David Eidelberg, Yilong Ma   +4 more
wiley   +1 more source

Synthesis and bioevaluation of new tacrine-cinnamic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Small molecule cholinesterases inhibitor (ChEI) provides an effective therapeutic strategy to treat Alzheimer’s disease (AD). Currently, the discovery of new ChEI with multi-target effect is still of great importance.
Yao Chen, Jie Zhu, J. Mo, Hongyu Yang, Xueyang Jiang, Hongzhi Lin, Kai Gu, Yuqiong Pei, Liang Wu, R. Tan, Jingxia Hou, Jingyi Chen, Yang Lv, Yaoyao Bian, Haopeng Sun   +14 more
semanticscholar   +1 more source

EFNB3 Frameshift Variant in Weimaraner Dogs with a Condition Resembling a Congenital Mirror Movement Disorder

Movement Disorders, EarlyView.
ABSTRACT Background Congenital mirror movement disorders (CMMs) are clinically and genetically heterogeneous in human patients. CMMs have not been documented to occur spontaneously in animals. Objective The objective of this work was to document the first case of CMMs spontaneously occurring in Weimaraner dogs and to identify the underlying genetic ...
Cleo Schwarz, Florian Bartenschlager, Olivia Kershaw, Judith Braun, Julien Guevar, Vidhya Jagannathan, Jörg T. Epplen, Wencke Reineking, Wolfgang Baumgärtner, Kailash P. Bhatia, Achim D. Gruber, Tosso Leeb   +11 more
wiley   +1 more source

Tremor Asymmetry and the Development of Bilateral Phase‐Specific Deep Brain Stimulation for Postural Tremor

Movement Disorders, EarlyView.
Abstract Background Tremor phase‐locked deep brain stimulation (DBS) has been shown to modulate symptom severity in postural tremor, including essential and dystonic tremor, with less energy than existing systems. Previous studies focused on unilateral stimulation; it remains unknown how tremor asymmetry interacts with stimulation in the context of ...
Shenghong He, Alceste Deli, Timothy O. West, Fernando R. Plazas, Alek Pogosyan, Christoph Wiest, Laura Wehmeyer, Fahd Baig, Francesca Morgante, Pablo Andrade, Michael G. Hart, James J. FitzGerald, Veerle Visser‐Vandewalle, Erlick A. Pereira, Alexander L. Green, Huiling Tan, Hayriye Cagnan   +16 more
wiley   +1 more source

Stroke Mimicking Thalamotomy in Primary Familial Brain Calcification

Movement Disorders Clinical Practice, EarlyView.
Jaakko Kungshamn, Emma Ottela, Olli Likitalo, Anna Brück, Juho Joutsa   +4 more
wiley   +1 more source

Protective Effects of Genetic Proxies of Cognitive Reserve in Parkinson's Disease: A Longitudinal Multi‐Cohort Study

Movement Disorders, EarlyView.
ABSTRACT Background Resilience factors are crucial in the progression of neurodegenerative diseases. However, it remains unclear whether a genetic predisposition to cognitive reserve influences clinical heterogeneity in the prognosis of Parkinson's disease (PD).
Young Eun Huh, Beomjin Jang, Sang‐Hyuk Jung, Dokyoon Kim, Towfique Raj, Hong‐Hee Won   +5 more
wiley   +1 more source

Phytocomponents and evaluation of acetylcholinesterase inhibition by Ginkgo biloba L. leaves extract depending on vegetation period

CyTA - Journal of Food, 2020
Leaves of the Ginkgo biloba L. have been identified as a source of bioactive compounds and their consumption may lead to the improvement of the brain function.
Joanna Kobus-Cisowska, Marcin Dziedziński, Oskar Szczepaniak, Weronika Kusek, Dominik Kmiecik, Marta Ligaj, Aleksandra Telichowska, Szymon Byczkiewicz, Piotr Szulc, Dominik Szwajgier   +9 more
doaj   +1 more source

Central Pathophysiology and Brain Network Changes Related to Camptocormia in Parkinson's Disease

Movement Disorders, EarlyView.
ABSTRACT Background Studies on brain connectivity offer important insights into the changes that occur in central network diseases such as Parkinson's disease (PD). Camptocormia, a condition characterized by abnormal flexion of the trunk, often occurs in advanced PD, but its underlying mechanisms are not yet clear.
Tauqeer Anjum, Jan Raethjen, Hao Ding, Nabin Koirala, Rüdiger Pryss, Robin Wolke, Chi Wang Ip, Günther Deuschl, Jens Volkmann, Nils G. Margraf, Muthuraman Muthuraman   +10 more
wiley   +1 more source