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Antidotal Effects of the Antihistamine Diphenhydramine Against Cholinesterase Inhibitor Poisoning: A Meta-Analysis of Median Lethal Doses in Experimental Animals. [PDF]

Cureus
Mohammad FK, Mohammed AA, Faris GA, Al-Baggou B, Mousa YJ.   +4 more
europepmc   +1 more source

New views on physiological functions and regulation of butyrylcholinesterase and potential therapeutic interventions. [PDF]

Front Mol Biosci
Hajimohammadi S, Lockridge O, Masson P.
europepmc   +1 more source

Insights on the mechanism of action of class IIa bacteriocins [PDF]

, 2019
Barbiroli A., D’Incecco P., Fessas D., Mapelli C., Motta P., Musatti A., Pellegrino S., Rollini M., Saitta F.   +8 more
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Nonquaternary Reactivators for Organophosphate-Inhibited Cholinesterases

Journal of Medicinal Chemistry, 2011
A new class of amidine-oxime reactivators of organophosphate (OP)-inhibited cholinesterases (ChE) was synthesized and tested in vitro and in vivo. Compared with 2-PAM, the most promising cyclic amidine-oxime (i.e., 12e) showed comparable or greater reactivation of OP-inactivated AChE and OP-inactivated BChE.
Jarosław, Kalisiak, Erik C, Ralph, John R, Cashman   +2 more
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Reactivators of organophosphate-inhibited cholinesterase

Archives of Toxicology, 1984
Two isomeric cyclopentylcarbonyl and two cycloheptylcarbonyl derivatives of 2-hydroxyiminomethyl-1-[3-(1-pyridinio-2-oxapropyl]pyr idinium diiodide and 4-hydroxyiminomethyl-1-[3-(1-pyridinio-2-oxapropyl]pyr idinium diiodide were prepared and characterized by spectroscopic methods.
M, Maksimović, I, Bregovec, V, Deljac, Z, Binenfeld   +3 more
openaire   +2 more sources

Reactivators of organophosphate-inhibited cholinesterase

Archives of Toxicology, 1982
Eleven isomeric phenylhydroxymethyl and cyclohexylhydroxymethyl derivatives of 1-(2-hydroxyiminomethyl-1-pyridinio)-3-(1-pyridinio)-2-oxapropane diiodide and 1-(4-hydroxyiminomethyl-1-pyridinio)-3-(1-pyridinio)-2-oxapropane diiodide were prepared and characterized by spectroscopic methods and pKa values.
V, Deljac, M, Maksimović, L, Radović, D, Rakin, V, Markov, I, Bregovec, Z, Binenfeld   +6 more
openaire   +2 more sources

Cholinesterase Reactivators Derived from Pyridine-2-carbaldoxime

Collection of Czechoslovak Chemical Communications, 1998
Monoquaternary reactivators of cholinesterase 3a-3c were prepared by quaternization of substituted pyridine-2-carbaldoximes with an ester (1a, 1b) or carbamoyl (2) function in position 4. A new bisquaternary reactivator, 4-carbamoyl-2'-[(hydroxyimino)methyl]-1,1'-(but-2-ene-1,4-diyl)bispyridinium salt (5), was derived from the unsubstituted pyridine-2 ...
Jiří Bielavský, Jiří Kassa, Iva Elsnerová, Luboš Dejmek   +3 more
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Non-oxime reactivators of organophosphate-inhibited cholinesterases

Archives of Toxicology
Organophosphorus compounds, including pesticides and nerve agents, irreversibly inhibit acetylcholinesterase, leading to an accumulation of acetylcholine that can cause a cholinergic crisis. Standard treatment of organophosphate poisoning relies on oxime-based reactivators, such as pralidoxime, obidoxime, or asoxime.
Karolina Knittelova, Zuzana Kohoutova, Eliska Prchalova, Kamil Musilek, David Malinak   +4 more
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Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics

Archives of Toxicology, 1999
Human poisoning by organophosphates bearing two methoxy groups, e.g. by malathion, paraoxon-methyl, dimethoate and oxydemeton-methyl, is generally considered to be rather resistant to oxime therapy. Since the oxime effectiveness is influenced not only by its reactivating potential but also by inhibition, aging and spontaneous reactivation kinetics ...
F, Worek, C, Diepold, P, Eyer
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