Results 131 to 140 of about 15,570 (165)

Mutant Cholinesterases Possessing Enhanced Capacity for Reactivation of Their Phosphonylated Conjugates

Biochemistry, 2004
Selective mutants of mouse acetylcholinesterase (AChE; EC 3.1.1.7) phosphonylated with chiral S(P)- and R(P)-cycloheptyl, -3,3-dimethylbutyl, and -isopropyl methylphosphonyl thiocholines were subjected to reactivation by the oximes HI-6 and 2-PAM and their reactivation kinetics compared with wild-type AChE and butyrylcholinesterase (EC 3.1.1.8 ...
Kovarik, Zrinka, Radić, Zoran, Berman, Harvey A., Simeon-Rudolf, Vera, Reiner, Elsa, Taylor, Palmer   +5 more
openaire   +6 more sources

Dealkylation and Loss of Capacity for Reactivation of Cholinesterase Inhibited by Sarin

Science, 1966
Inhibition of rat brain acetylcholinesterase by 32 P-sarin in vivo results initially in 32 P-isopropylmethylphosphonylated enzyme. The percentage of inhibited enzyme that could not be reactivated by pyridinium aldoxime methochloride (aged enzyme) approximated the amount of radioactivity ...
L W, Harris, J H, Fleisher, J, Clark, W J, Cliff   +3 more
openaire   +2 more sources

Reactivity of Diabetic Urinary Bladder to the Cholinesterase Inhibitor Neostigmine

Urology, 2014
To examine the effects of neostigmine, an acetylcholinesterase inhibitor that has been used to treat impaired bladder emptying on diabetic rat urinary bladder smooth muscle.Rat urinary detrusor muscle strips were suspended in organ baths containing Krebs' solution for isometric tension recording.
Seham, Mustafa, Hishaam N, Ismael
openaire   +2 more sources

In vivo reactivation by pam of brain cholinesterase inhibited by paraoxon

Biochemical Pharmacology, 1960
Abstract Pyridine-2-aldoxime methiodide (PAM) injected in amounts of from 25 to 150 mg/kg from 0.5 to 1.5 hr after 0.15 mg/kg paraoxon caused a significant increase in the cholinesterase levels of cerebral cortex, pons, cerebellum, region of area postrema in medulla, and the remainder of the medulla of rabbits killed 3 hr after the injection of ...
openaire   +2 more sources

Uncharged reactivators of OP-inhibited cholinesterases

2019
The acute toxicity of OPNA (organophosphorus nerve agent) results from irreversible inhibition of AChE, a key enzyme in neurotransmission, via the formation of a covalent P-O bond at the catalytic serine. Inhibition of AChE leads to the accumulation of acetylcholine neurotransmitter (ACh) in the synaptic cleft causing among other symptoms, seizures and
Dubois-Geoffroy, P., Probst, N., Gasnot, J., Renard, Pierre-Yves, Braiki, Anissa, Warnault, P., Jean, Ludovic, Zorbaz, Tamara, Maraković, Nikola, Kovarik, Zrinka, Dias, Jose, Calas, G, Nachon, Florian, Baati, Rachid   +13 more
openaire   +2 more sources

Cholinesterase inhibition by methamidophos and its subsequent reactivation

Pesticide Biochemistry and Physiology, 1980
Abstract Methamidophos (O,S-dimethylphosphoramidothioate, Monitor) is an organophosphorus, cholinesterase-inhibiting insecticide. The rate constant (ki) for inhibiting rat plasma cholinesterase (ChE) was 1.57 ± 0.03 × 103 M−1 min−1, for rat erythrocyte ChE was 8.86 ± 1.10 × 103 M−1 min−1, and for rat brain ChE was 6.58 ± 0.42 M−1 min−1.
Casey P. Robinson, Donald Beiergrohslein
openaire   +1 more source

[Trial of cholinesterase reactivators as proserine antagonists].

Biulleten' eksperimental'noi biologii i meditsiny, 1983
HI-6 and TMB-4 were the most effective and safe of 7 cholinesterase reactivators tested as agents for the prophylaxis of proserine poisoning of male mice. The reactivator HI-6 strongly potentiated the prophylactic efficacy of a mixture of atropine and arpenal administered in the doses sufficient for the blockade of both the m- and h-cholinoreactive ...
V B, Prozorovskiĭ, E A, Khramova, T V, Ardab'eva   +2 more
openaire   +1 more source

The ganglionic blocking properties of the cholinesterase reactivator, HS-6

Canadian Journal of Physiology and Pharmacology, 1978
Following intravenous administration of the cholinesterase reactivator HS-6 (30 mg/kg), blood pressure fell (up to 50 mmHg) and maximal blood levels of HS-6 reached 242 μg/ml. HS-6 attenuated the pressor response resulting from carotid occlusion and the depressor effect of vagal stimulation.
openaire   +2 more sources

OXIME REACTIVATION STUDIES OF INHIBITED TRUE AND PSEUDO CHOLINESTERASE

Canadian Journal of Biochemistry and Physiology, 1959
Electric eel cholinesterase and purified pseudo cholinesterase from horse serum were inhibited with sarin, tabun, or O, O-diethyl-S-2-diethylaminoethyl phosphorothiolate. The inhibited enzymes were then reactivated at 25 °C with one of the oximes: pyridine 2-aldoxime methiodide, 1, 1′-trimethylene bis (4-hydroximinomethyl pyridinum) bromide, and 1-(3 ...
openaire   +3 more sources

Action of Reactivators of Cholinesterase Applied by Inhalation

Chemotherapia, 2009
B, BOSKOVIC, P, STERN
openaire   +2 more sources