Results 121 to 130 of about 15,570 (165)
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Cholinesterase reactivators — Contribution to the study of their metabolic effects
Experientia, 1976Cholinesterase reactivators - trimedoxim, methoxim and obidoxim - injected in the dose of 20 mg/kg s.c., increase muscle glycogen concentration in normal, but not in adrenalectomized rats. This effect may be in connection with simoultaneously found rise of serum corticosteron level.
Jindrich Musil, O Benesova
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Nonquaternary Reactivators for Organophosphate-Inhibited Cholinesterases
Journal of Medicinal Chemistry, 2011A new class of amidine-oxime reactivators of organophosphate (OP)-inhibited cholinesterases (ChE) was synthesized and tested in vitro and in vivo. Compared with 2-PAM, the most promising cyclic amidine-oxime (i.e., 12e) showed comparable or greater reactivation of OP-inactivated AChE and OP-inactivated BChE.
Jarosław, Kalisiak +2 more
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Chemico-Biological Interactions, 2017 International audienceOrganophosphorus nerve agents, like VX, are highly toxic due to their strong inhibition potency against acetylcholinesterase (AChE). AChE inhibited by VX can be reactivated using powerful nucleophilic molecules, most commonly oximes,
André-Guilhem Calas +2 more
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Trials of cholinesterase reactivators as neostigmine antagonists
Bulletin of Experimental Biology and Medicine, 1983V. B. Prozorovskii +2 more
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The history of cholinesterase reactivation: hydroxylamine and pyridinium aldoximes.
Die Pharmazie, 2012Hydroxylamine (NH2OH) the substance which will turn out to be of importance to those interested in the treatment of organophosporus cholinesterase inhibitor exposure, was synthesized by Wilhem Clemens Lossen in 1865 while working in Halle as an assistant in the laboratory of Wilhelm Heinrich Heintz.
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Reactivation of alkylphosphorylated cholinesterase by a constituent of liver
International Journal of Neuropharmacology, 1962Summary One of the substances present in the dialysate of liver homogenate and effective as reactivators of phosphorylated acetylcholinesterase has been isolated and identified.
V. Neuhoff, H. Kewitz
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Non-oxime reactivators of organophosphate-inhibited cholinesterases
Archives of ToxicologyOrganophosphorus compounds, including pesticides and nerve agents, irreversibly inhibit acetylcholinesterase, leading to an accumulation of acetylcholine that can cause a cholinergic crisis. Standard treatment of organophosphate poisoning relies on oxime-based reactivators, such as pralidoxime, obidoxime, or asoxime.
Karolina Knittelova +4 more
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Identical reactivity of brain and erythrocyte cholinesterases of some mammals
Journal of Evolutionary Biochemistry and Physiology, 2009The paper deals with a comparative study of various aspects of reactivity (substrate and inhibitor specificity, sensitivity to action of hydrophobic organophosphorus inhibitors, capability for reactivation) of preparations of the brain, erythrocyte, and serum cholinesterases of a group of mammals (human, rabbit, rat, cattle, dog, and cat).
N E, Basova, E V, Rozengart
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Reactivators of organophosphate-inhibited cholinesterase
Archives of Toxicology, 1982Eleven isomeric phenylhydroxymethyl and cyclohexylhydroxymethyl derivatives of 1-(2-hydroxyiminomethyl-1-pyridinio)-3-(1-pyridinio)-2-oxapropane diiodide and 1-(4-hydroxyiminomethyl-1-pyridinio)-3-(1-pyridinio)-2-oxapropane diiodide were prepared and characterized by spectroscopic methods and pKa values.
V, Deljac +6 more
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Reactivators of organophosphate-inhibited cholinesterase
Archives of Toxicology, 1984Two isomeric cyclopentylcarbonyl and two cycloheptylcarbonyl derivatives of 2-hydroxyiminomethyl-1-[3-(1-pyridinio-2-oxapropyl]pyr idinium diiodide and 4-hydroxyiminomethyl-1-[3-(1-pyridinio-2-oxapropyl]pyr idinium diiodide were prepared and characterized by spectroscopic methods.
M, Maksimović +3 more
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