Results 131 to 140 of about 853 (162)

Novel oximes as blood–brain barrier penetrating cholinesterase reactivators

Chemico-Biological Interactions, 2010
The US Army utilizes pralidoxime (2-PAM) for the reactivation of OP-inhibited AChE. While 2-PAM effectively reactivates acetylcholinesterase (AChE) in the body, it does not cross the blood-brain barrier (BBB) at therapeutically relevant levels. To address this problem of central nervous system AChE reactivation, novel sugar-oxime conjugates were ...
Gregory E, Garcia, Amy J, Campbell, John, Olson, Deborah, Moorad-Doctor, Venee I, Morthole   +4 more
openaire   +2 more sources

CARBOFURAN POISONING IN HERONS: DIAGNOSIS USING CHOLINESTERASE REACTIVATION TECHNIQUES

Journal of Wildlife Diseases, 1995
Exposure to the carbamate insecticide carbofuran was detected using brain cholinesterase (ChE) reactivation techniques in heron carcasses collected from a potential pesticide exposure incident. Great egrets (Nycticorax nycticorax), great blue herons (Ardea herodias), and black-crowned night herons (Casmerodius albus) were exposed to carbofuran (2,3 ...
K A, Hunt, M J, Hooper, E E, Littrell
openaire   +2 more sources

Uncharged reactivators of OP-inhibited cholinesterases

2019
The acute toxicity of OPNA (organophosphorus nerve agent) results from irreversible inhibition of AChE, a key enzyme in neurotransmission, via the formation of a covalent P-O bond at the catalytic serine. Inhibition of AChE leads to the accumulation of acetylcholine neurotransmitter (ACh) in the synaptic cleft causing among other symptoms, seizures and
Dubois-Geoffroy, P., Probst, N., Gasnot, J., Renard, Pierre-Yves, Braiki, Anissa, Warnault, P., Jean, Ludovic, Zorbaz, Tamara, Maraković, Nikola, Kovarik, Zrinka, Dias, Jose, Calas, G, Nachon, Florian, Baati, Rachid   +13 more
openaire   +2 more sources

Cholinesterase inhibition by methamidophos and its subsequent reactivation

Pesticide Biochemistry and Physiology, 1980
Abstract Methamidophos (O,S-dimethylphosphoramidothioate, Monitor) is an organophosphorus, cholinesterase-inhibiting insecticide. The rate constant (ki) for inhibiting rat plasma cholinesterase (ChE) was 1.57 ± 0.03 × 103 M−1 min−1, for rat erythrocyte ChE was 8.86 ± 1.10 × 103 M−1 min−1, and for rat brain ChE was 6.58 ± 0.42 M−1 min−1.
Casey P. Robinson, Donald Beiergrohslein
openaire   +1 more source

The reactivation of carbamate-inhibited cholinesterase, kinetic parameters

Pesticide Biochemistry and Physiology, 1973
Abstract The rates of spontaneous regeneration or decarbamylation of fly-head and bovine erythrocyte cholinesterase inhibited by methyl- and dimethylcarbamic acid esters were determined under different conditions of pH, salt concentrations, and temperature using Sephadex gel filtration as a means of isolating the carbamylated enzyme.
W.Douglas Reed, T.R. Fukuto
openaire   +1 more source

Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases

Archives of Toxicology, 1998
Cyclohexylmethylphosphonofluoridate (cyclosarin) is a highly toxic organophosphate, which was shown to be rather resistant to conventional oxime therapy. To give more insight into the inhibition, reactivation and aging kinetics, human acetyl-(AChE) and butyrylcholinesterase (BChE) were inhibited by cyclosarin (k2 of 7.4 and 3.8 x 10(8) M(-1) min(-1 ...
F, Worek, P, Eyer, L, Szinicz
openaire   +2 more sources

Identical reactivity of brain and erythrocyte cholinesterases of some mammals

Journal of Evolutionary Biochemistry and Physiology, 2009
The paper deals with a comparative study of various aspects of reactivity (substrate and inhibitor specificity, sensitivity to action of hydrophobic organophosphorus inhibitors, capability for reactivation) of preparations of the brain, erythrocyte, and serum cholinesterases of a group of mammals (human, rabbit, rat, cattle, dog, and cat).
N E, Basova, E V, Rozengart
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[Trial of cholinesterase reactivators as proserine antagonists].

Biulleten' eksperimental'noi biologii i meditsiny, 1983
HI-6 and TMB-4 were the most effective and safe of 7 cholinesterase reactivators tested as agents for the prophylaxis of proserine poisoning of male mice. The reactivator HI-6 strongly potentiated the prophylactic efficacy of a mixture of atropine and arpenal administered in the doses sufficient for the blockade of both the m- and h-cholinoreactive ...
V B, Prozorovskiĭ, E A, Khramova, T V, Ardab'eva   +2 more
openaire   +1 more source

OXIME REACTIVATION STUDIES OF INHIBITED TRUE AND PSEUDO CHOLINESTERASE

Canadian Journal of Biochemistry and Physiology, 1959
Electric eel cholinesterase and purified pseudo cholinesterase from horse serum were inhibited with sarin, tabun, or O, O-diethyl-S-2-diethylaminoethyl phosphorothiolate. The inhibited enzymes were then reactivated at 25 °C with one of the oximes: pyridine 2-aldoxime methiodide, 1, 1′-trimethylene bis (4-hydroximinomethyl pyridinum) bromide, and 1-(3 ...
openaire   +3 more sources

Cholinesterase reactivators — Contribution to the study of their metabolic effects

Experientia, 1976
Cholinesterase reactivators - trimedoxim, methoxim and obidoxim - injected in the dose of 20 mg/kg s.c., increase muscle glycogen concentration in normal, but not in adrenalectomized rats. This effect may be in connection with simoultaneously found rise of serum corticosteron level.
O, Benesová, J, Hvizdosová, J, Musil, M, Kraus, R, Erdösová   +4 more
openaire   +2 more sources