Zebrafish models for human acute organophosphorus poisoning [PDF]
, 2015 Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war ...
Arick II, Mark +17 more
core +4 more sources
Protein Science, Volume 33, Issue 8, August 2024.Abstract Cholinesterases are well‐known and widely studied enzymes crucial to human health and involved in neurology, Alzheimer's, and lipid metabolism. The protonation pattern of active sites of cholinesterases influences all the chemical processes within, including reaction, covalent inhibition by nerve agents, and reactivation.
Alexander Zlobin +2 more
wiley +1 more source
Sarin Assay using Acetylcholinesterases and Electrochemical Sensor Strip [PDF]
, 2009 An electrochemical sensor strip was used for sarin assay. Three different acetylcholinesterases (AChEs) were chosen as promising recognition elements. viz., human recombinant, electric eel, and bovine erythrocytes origin.
Binder, Jiri +2 more
core +2 more sources
Efficacy of Novel Pyridinium Oximes against Two Organophosphates in Female Sprague Dawley Rats [PDF]
, 2019 Anticholinesterase organophosphate (OP) compounds were developed as insecticides and are also used as nerve agents in chemical warfare. Treatment against acute OP toxicity includes oximes which reactivate phosphorylated acetylcholinesterase (AChE ...
Garcia, Jason Michael
core +1 more source
A Synthetic Study of an Organophosphorous Compound as an Acetylcholinesterase Inhibitor [PDF]
, 1994 Acetylcholinesterase is the enzyme that catalyzes the hydrolysis of acetylcholine. Based on the transition state of the catalysis, and what is known about the structure of the enzyme, a synthetic study has been conducted on an organophosphorous inhibitor
Jhaveri \u2794, Sulay
core +1 more source
Tratamiento de la intoxicación por organofosforados en aves rapaces [PDF]
El amplio uso de los organofosforados, pesticidas anticolinesterásicos, ha sido responsable en ciertas ocasiones de la mortalidad y morbilidad observada en aves silvestres. Los OP son un tipo de insecticidas utilizados desde los años cuarenta, que pueden
Hernández Vicente, Tomás J. +2 more
core +1 more source
Experimental Oximes as Organophosphate Preexposure Prophylaxis. Lessons from the Gulf War Syndrome [PDF]
The present study was undertaken in order to determine if established or experimental K-oximes can protect from OP (paraoxon) toxicity. Rats that received only the OP were compared with those that had received oxime pretreatment before OP exposure.
Kuca, Kamil +2 more
core +2 more sources
Further developments in the treatment of poisoning with alkylphosphate (Organophosphate) insecticides [PDF]
, 2019 No ...
Steyn, Doug G.
core +1 more source
In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. [PDF]
Chem Res Toxicol, 2023 Váňová N +5 more
europepmc +1 more source
Supstituirani monokvaterni oksimi kao reaktivatori acetilkolinesteraze inhibirane ciklosarinom i klorpirifosom [PDF]
, 2006 This paper describes an in vitro study of three potential acetylcholinesterase (AChE; EC 3.1.1.7) reactivators derived from a monoquaternary reactivator pralidoxime.
Daniel Jun +3 more
core +1 more source