Results 41 to 50 of about 411 (95)

Crohn’s Disease Presenting as an Abdominal Wall Abscess in an Adolescent With Autism Spectrum Disorder

Case Reports in Pediatrics, Volume 2026, Issue 1, 2026.
Crohn’s disease (CD) is a subtype of inflammatory bowel disease characterized by discontinuous lesions and transmural inflammation. Delayed diagnosis may lead to fistula formation between the intestine and adjacent organs. However, most CD‐associated fistulas are enteroenteric or perianal, and abdominal wall abscesses are rarely reported in pediatric ...
Kohsuke Hitomi, Shuichi Katayama, Soichi Nakada, Shojiro Hanaki, Satabdi Datta Choudhury   +4 more
wiley   +1 more source

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi, Shiler Khaledi, Kimia Ahmadi, Kambiz Hassanzadeh   +3 more
wiley   +1 more source

A systems immunology analysis of Alzheimer's disease reveals an age‐ and environmental exposure‐independent disturbance in B cell maturation

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Alzheimer's disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinical investigation suggests a neuroimmunological component to disease, with links to the peripheral immune system.
Stephanie Humblet‐Baron, Yang Feng, Rafael Veiga, Julika Neumann, Teresa Prezzemolo, Emanuela Pasciuto, Rik Vandenberghe, Lidia Yshii, Adrian Liston   +8 more
wiley   +1 more source

Cardiorespiratory Response to Exercise in Parkinson's Disease: Associations with Autonomic Dysfunction and Physical Activity

Movement Disorders Clinical Practice, Volume 12, Issue 11, Page 1882-1890, November 2025.
Abstract Background Both autonomic dysfunction and low levels of physical activity could contribute to reduced cardiorespiratory fitness in people with Parkinson's disease (PD). However, the interrelationship between these concepts is not well understood.
Kars I. Veldkamp, Sabine Schootemeijer, Hilde Joosten, Bastiaan R. Bloem, Luc J.W. Evers, Nienke M. de Vries   +5 more
wiley   +1 more source

Organophosphate Poisoning: Insights From a Case Report of Acute Cholinergic Syndrome

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Organophosphate (OP) pesticides are widely used in agriculture and can cause acute cholinergic toxicity by inhibiting the enzyme acetylcholinesterase, leading to an accumulation of acetylcholine. A 45‐year‐old male plumber was admitted to the emergency department 4 h after ingesting an unknown quantity of a 50% emulsifiable concentration of ...
Gudisa Bereda
wiley   +1 more source

Gene and RNA Editing: Revolutionary Approaches to Treating Diseases

MedComm, Volume 6, Issue 10, October 2025.
The image illustrates gene editing technologies: DNA editing using CRISPR–Cas9 and RNA editing via Cas13d, with their clinical applications and ethical risks. DNA editing allows precise gene modifications for conditions like amyotrophic lateral sclerosis [ALS] and Huntington's disease, while RNA editing supports multiplexed modifications.
Jia‐Mei Li, Jie Huang, Yan Liao, Ting Hu, Chang‐Li Wang, Wang‐Zheqi Zhang, Chen‐Wei Huang   +6 more
wiley   +1 more source

In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. [PDF]

Chem Res Toxicol, 2023
Váňová N, Múčková L, Kalíšková T, Lochman L, Bzonek P, Švec F.   +5 more
europepmc   +1 more source

Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides. [PDF]

J Enzyme Inhib Med Chem, 2022
Kohoutova Z, Malinak D, Andrys R, Svobodova J, Psotka M, Schmidt M, Prchal L, Musilek K.   +7 more
europepmc   +1 more source

The in silico identification of novel broad-spectrum antidotes for poisoning by organophosphate anticholinesterases. [PDF]

J Comput Aided Mol Des, 2023
Habiballah S, Chambers J, Meek E, Reisfeld B.   +3 more
europepmc   +1 more source

Isatin-pyridine oxime hybrids as potential reactivators of A-242-inhibited acetylcholinesterase. [PDF]

Arch Toxicol
Pinto AMV, Bhattacharyya D, da Silva MCJ, Kitagawa DAS, Dos Santos MC, Cavalcante SFA, Islam ST, LaPlante SR, Forgione P, Diz JSF, França TCC.   +10 more
europepmc   +1 more source