Results 21 to 30 of about 411 (95)

Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Molecules, 2009
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and ...
Daniel Jun, Jana Zdarova Karasova, Miroslav Pohanka, Martina Hrabinova, Kamil Musilek, Martin Paar, Vladimir Cirkva, Jiri Palecek, Kamil Kuca, Lucie Musilova   +9 more
doaj   +1 more source

Combined Pre- and Posttreatment of Paraoxon Exposure

Molecules, 2020
Aims: Organophosphates (OPCs), useful agents as pesticides, also represent a serious health hazard. Standard therapy with atropine and established oxime-type enzyme reactivators is unsatisfactory.
Dietrich E Lorke, Syed M Nurulain, Mohamed Y Hasan, Kamil Kuča, Georg A Petroianu   +4 more
doaj   +1 more source

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE ...
David Malinak, Rafael Dolezal, Vendula Hepnarova, Miroslava Hozova, Rudolf Andrys, Petr Bzonek, Veronika Racakova, Jan Korabecny, Lukas Gorecki, Eva Mezeiova, Miroslav Psotka, Daniel Jun, Kamil Kuca, Kamil Musilek   +13 more
doaj   +1 more source

Organophosphate Poisoning Simulation Case

MedEdPORTAL, 2010
This simulation case is intended for medical students and residents in emergency medicine and involves a patient that was exposed to organophosphates while working on a farm.
Jessica Brooks, Amy Zosel, Britney Anderson   +2 more
doaj   +1 more source

Clinical characteristics and treatment of mixed-pesticide poisoning in a patient: reflections on a particular case

Journal of International Medical Research, 2020
Patients who commit suicide often deliberately hide their medical history. Given that taking pesticides is one of the most common methods of suicide, other forms of poisoning may be neglected in clinical practice. We report here a case of mixed-pesticide
Yiming Tao, Tingting Liu, Jie Han, Xiangdong Jian, Baotian Kan   +4 more
doaj   +1 more source

The Experimental Oxime K027—A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime

Frontiers in Neuroscience, 2019
Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory.
Dietrich E. Lorke, Dietrich E. Lorke, Georg A. Petroianu   +2 more
doaj   +1 more source

Organophosphorus Poisoning

Journal of Nepal Medical Association, 2008
Acute poisoning by organophosphorus (OP) compounds is a major global clinical problem, with thousands of deaths occurring every year. Most of these pesticide poisoning and subsequent deaths occur in developing countries following a deliberate self ...
Buddhi Prasad Paudyal
doaj   +1 more source

Computational Design, Molecular Docking Study and Toxicity Prediction of Some Novel Pralidoxime Derivatives as reactivators of acetyl cholinesterase enzyme [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & Objective: oximes as Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate compounds (OPCs) intoxication.
abozar roeintan
doaj  

A Study on Two Dose Regimens of Pralidoxime in the Management of Organophosphate Poisoning [PDF]

Asia Pacific Journal of Medical Toxicology, 2013
Background: The role and proper dose of pralidoxime in the treatment of Organophosphorus (OP) compounds poisoning is an unresolved issue .This study was designed to compare the regimen recommended by the World Health Organization (WHO) with the commonly ...
Mahadevaiah Mahesh, Mohan Gowdar, Chilkunda Venkatesh   +2 more
doaj  

In Vitro Antioxidant, Antibacterial, and Cholinesterase‐Inhibitory Properties of an Aqueous Euphorbia macroclada Root Extract Obtained by Ultrasound‐Assisted Extraction

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
The aqueous root extract of Euphorbia macroclada was obtained using ultrasound‐assisted extraction (UAE). The extract showed remarkable butyrylcholinesterase (BChE) inhibition relevant to Alzheimer's disease. Strong antioxidant capacity was demonstrated through multiple radical scavenging and reducing assays.
Abdulkadir Gül, Fırat Yılmaz, Fevzi Topal, İnanç Özgen, Ercan Aydoğmuş, Hasan Arslanoğlu   +5 more
wiley   +1 more source