Results 21 to 30 of about 15,570 (165)
Frontiers in Neuroscience, 2019 Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory.
Dietrich E. Lorke +2 more
doaj +1 more source
Oxime Reactivation of Diethylphosphoryl Human Serum Cholinesterase
Journal of Biological Chemistry, 1967 Abstract Reactivation of diethyl p-nitrophenyl phosphate inhibited human serum cholinesterase by pyridine-2-aldoxime methiodide and isonitrosoacetophenone has been investigated as a function of reactivator concentration, pH, and temperature in boric acid-borax buffer and in salt solution.
E I, Wang, P E, Braid
openaire +2 more sources
Journal of Nepal Medical Association, 2008 Acute poisoning by organophosphorus (OP) compounds is a major global clinical problem, with thousands of deaths occurring every year. Most of these pesticide poisoning and subsequent deaths occur in developing countries following a deliberate self ...
Buddhi Prasad Paudyal
doaj +1 more source
Obidoxime Reactivation of Organophosphate-Inhibited Cholinesterase Activity in Pigs [PDF]
Acta Veterinaria Scandinavica, 1984 The ability of obidoxime to reactivate organophosphate-inhibited cholinesterases was studied in pigs treated with either trichlorfon, dichlorvos or coumaphos. In 6 pigs Cholinesterase activity was measured in the blood samples both before and after in vitro reactivation with obidoxime.
N, Gyrd-Hansen, I, Kraul
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CHOLINESTERASE INHIBITORS: A LITERATURE REVIEW OF MEDICATION EFFICACY AND SAFETY FOR ALZHEIMER'S DISEASE [PDF]
, 2021 Background: With a steady increase of seniors in Canada’s overall population, geriatric-associated illnesses such as Alzheimer’s disease (AD) will continue to rise. AD is a progressive neurodegenerative disorder that causes plaque build-up in the brain
Wicklund, Ashley
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A Study on Two Dose Regimens of Pralidoxime in the Management of Organophosphate Poisoning [PDF]
Asia Pacific Journal of Medical Toxicology, 2013 Background: The role and proper dose of pralidoxime in the treatment of Organophosphorus (OP) compounds poisoning is an unresolved issue .This study was designed to compare the regimen recommended by the World Health Organization (WHO) with the commonly ...
Mahadevaiah Mahesh +2 more
doaj
Topical Donepezil for Cholinergic Modulation in Chronic Wound Repair
Wound Repair and Regeneration, Volume 34, Issue 5, September/October 2026.ABSTRACT Chronic wounds result from combined defects in vascular perfusion, inflammatory resolution, and epithelial repair. The skin's non‐neuronal cholinergic system (NNCS), formed by keratinocytes, endothelial cells, fibroblasts, and immune cells that synthesise and respond to acetylcholine (ACh), helps coordinate these processes through muscarinic ...
Hui‐Qi Qu +2 more
wiley +1 more source
The kinetics of reactivation, by oximes, of cholinesterase inhibited by organophosphorus compounds [PDF]
Biochemical Journal, 1956 The inhibition of cholinesterase (ChE) and related enzymes, by organophosphorus compounds, is generally believed to occur by direct phosphorylation of some group at the active centre of the enzyme, together with the liberation of an acid anion (Wilson, 1951; Balls & Jansen, 1952; Hartley & Kilby, 1952; Aldridge, 1954; Kilby & Youatt, 1954).
D R, DAVIES, A L, GREEN
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Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview
MedComm, Volume 7, Issue 6, June 2026.The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele +7 more
wiley +1 more source
Avaliação dos efeitos tóxicos induzidos por malation e malaoxon e a possível proteção por oximas [PDF]
, 2013 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2013O malation é um composto tóxico pertencente à classe dos pesticidas organofosforados (OF) que tem como ...
Santos, Alessandra Antunes dos
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