Results 31 to 40 of about 411 (95)
A Guinea Green B/butyrylthiocholine iodide solution offers a simple visual colorimetric approach for detecting cholinesterase inhibitors (neostigmine, VX, and A‐234). The aqueous formulation remains practically functional after 150 days at 60 °C, whereas the phosphate‐buffered variant rapidly degrades.
Lukáš Matějovský +1 more
wiley +1 more source
Surgical Treatment for Hemorrhagic Infarction of Small Intestine Caused by Organophosphate Poisoning
ABSTRACT Acute organophosphorus pesticide poisoning (AOPP) may cause intestinal infarction via intra‐abdominal hypertension (IAH) and non‐occlusive mesenteric ischemia (NOMI). Although this complication carries high mortality, early laparotomy, resection of necrotic bowel, and comprehensive therapy can improve survival, as supported by our successfully
Yi‐Yun Sun +5 more
wiley +1 more source
Topical Donepezil for Cholinergic Modulation in Chronic Wound Repair
ABSTRACT Chronic wounds result from combined defects in vascular perfusion, inflammatory resolution, and epithelial repair. The skin's non‐neuronal cholinergic system (NNCS), formed by keratinocytes, endothelial cells, fibroblasts, and immune cells that synthesise and respond to acetylcholine (ACh), helps coordinate these processes through muscarinic ...
Hui‐Qi Qu +2 more
wiley +1 more source
Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele +7 more
wiley +1 more source
Molecular imprinting for neurology: Materials, applications, and limitations
Molecularly imprinted materials: diagnostic, therapeutic and research applications in neurology. Molecularly imprinted materials offer high specificity and affinity for target molecules in neurological applications. This review highlights their synthesis, characterisation, and use in diagnostics, research and therapeutics.
Xiaohan Ma +3 more
wiley +1 more source
Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review
Resveratrol induces the expressions of TP53, NRF2, and JDP2 axis in cancer cells to control ROS balance in mitochondria. The antioxidation responses were induced through SRIT1/3, HDAC, STAT3, TGFβ, and so on, to trigger the inflammation, and NFkB response to lead to the cell death of cancers or neuro‐damaged cells.
Kenly Wuputra +9 more
wiley +1 more source
ABSTRACT OP compounds, commonly used as pesticides, are readily available over the counter and frequently implicated in intentional poisoning. We report a case of a 43‐year‐old male with OP poisoning initially misdiagnosed as alcohol intoxication. He was intubated in the emergency department on arrival due to a low Glasgow Coma Scale (GCS) of 6/15 and ...
Sujan Tamang +6 more
wiley +1 more source
This study elucidates pesticide docking onto proteins encoded by differentially expressed genes, revealing interaction networks involving chemicals, genes, proteins, drugs and diseases. It highlights structural insights, regulatory pathways and potential therapeutic or environmental implications, providing a comprehensive understanding of the ...
Jyoti Kant Choudhari +4 more
wiley +1 more source
Electrical Synapses Contribute to Sleep‐Dependent Declarative Memory Retention
Blocking electrical synapses (gap junctions) in healthy humans by mefloquine impaired the sleep‐dependent retention of verbal declarative memory and improved sensorimotor memory consolidation irrespective of sleep. Mefloquine also disrupted the coupling of sleep spindles to EEG slow oscillations in humans but did not affect hippocampal sharp‐wave ...
Gordon B. Feld +9 more
wiley +1 more source
Intermediate syndrome (IMS) is a delayed neuromuscular complication of organophosphate poisoning, typically occurring 24–96 h postexposure and often leading to respiratory failure. The author reports a 39‐year‐old male who ingested 40% chlorpyrifos and developed IMS on Day 4 post‐ingestion, presenting with proximal muscle weakness, neck flexor ...
Gudisa Bereda, Lipi Buch
wiley +1 more source

