Results 11 to 20 of about 15,570 (165)

Computational Design, Molecular Docking Study and Toxicity Prediction of Some Novel Pralidoxime Derivatives as reactivators of acetyl cholinesterase enzyme [PDF]

Journal of Advanced Biomedical Sciences, 2019
Background & Objective: oximes as Acetylcholinesterase (AChE) reactivators were developed for the treatment of organophosphate compounds (OPCs) intoxication.
abozar roeintan
doaj   +1 more source

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
The series of symmetrical and unsymmetrical isoquinolinium-5-carbaldoximes was designed and prepared for cholinesterase reactivation purposes. The novel compounds were evaluated for intrinsic acetylcholinesterase (AChE) or butyrylcholinesterase (BChE ...
David Malinak, Rafael Dolezal, Vendula Hepnarova, Miroslava Hozova, Rudolf Andrys, Petr Bzonek, Veronika Racakova, Jan Korabecny, Lukas Gorecki, Eva Mezeiova, Miroslav Psotka, Daniel Jun, Kamil Kuca, Kamil Musilek   +13 more
doaj   +2 more sources

Novel cholinergic reactivators.

, 1988
Novel cholinergic ...
Pushpa Rao. Vavilikolanu (7975661)
core   +6 more sources

Cholinesterase Reactivation: In Vitro Studies [PDF]

Anaesthesia and Intensive Care, 1975
In vitro studies confirm the clinical impression that P–2–AM does not reverse the cholinesterase inhibition caused by organophosphorus insecticides.
A, Ganendran, S, Balabaskaran
openaire   +2 more sources

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime

Biomolecules, 2020
(1) Background: Human exposure to organophosphorus compounds employed as pesticides or as chemical warfare agents induces deleterious effects due to cholinesterase inhibition. One therapeutic approach is the reactivation of inhibited acetylcholinesterase
André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Catherine Rousseau, Charlotte Courageux, Xavier Brazzolotto, Pascal Villa, Adeline Obrecht, Jean-François Goossens, Christophe Landry, Johan Hachani, Fabien Gosselet, Marie-Pierre Dehouck, Jagadeesh Yerri, Maria Kliachyna, Rachid Baati, Florian Nachon   +18 more
doaj   +1 more source

Novel Bisquaternary Oximes—Reactivation of Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon

Molecules, 2009
Four novel bisquaternary aldoxime cholinesterase reactivators differing in their chemical structure were prepared. Afterwards, their biological activity was evaluated for their ability to reactivate acetylcholinesterase (AChE; EC 3.1.1.7) and ...
Daniel Jun, Jana Zdarova Karasova, Miroslav Pohanka, Martina Hrabinova, Kamil Musilek, Martin Paar, Vladimir Cirkva, Jiri Palecek, Kamil Kuca, Lucie Musilova   +9 more
doaj   +1 more source

Combined Pre- and Posttreatment of Paraoxon Exposure

Molecules, 2020
Aims: Organophosphates (OPCs), useful agents as pesticides, also represent a serious health hazard. Standard therapy with atropine and established oxime-type enzyme reactivators is unsatisfactory.
Dietrich E Lorke, Syed M Nurulain, Mohamed Y Hasan, Kamil Kuča, Georg A Petroianu   +4 more
doaj   +1 more source

Organophosphate Poisoning Simulation Case

MedEdPORTAL, 2010
This simulation case is intended for medical students and residents in emergency medicine and involves a patient that was exposed to organophosphates while working on a farm.
Jessica Brooks, Amy Zosel, Britney Anderson   +2 more
doaj   +1 more source

Clinical characteristics and treatment of mixed-pesticide poisoning in a patient: reflections on a particular case

Journal of International Medical Research, 2020
Patients who commit suicide often deliberately hide their medical history. Given that taking pesticides is one of the most common methods of suicide, other forms of poisoning may be neglected in clinical practice. We report here a case of mixed-pesticide
Yiming Tao, Tingting Liu, Jie Han, Xiangdong Jian, Baotian Kan   +4 more
doaj   +1 more source

New heterostilbenes as potential cholinesterase inhibitors or reactivators – synthesis and photochemistry

, 2023
U ovoj disertaciji, predložena je sinteza novih stilbenskih derivata koje u svojim strukturama sadrže heterocikličke jezgre furana, tiofena, triazola, tiazola i piranona.
Mlakić, Milena
core   +3 more sources