Results 61 to 70 of about 15,570 (165)

In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. [PDF]

Chem Res Toxicol, 2023
Váňová N, Múčková L, Kalíšková T, Lochman L, Bzonek P, Švec F.   +5 more
europepmc   +1 more source

Phenyltetrahydroisoquinoline–Pyridinaldoxime Conjugates as Efficient Uncharged Reactivators for the Dephosphylation of Inhibited Human Acetylcholinesterase

, 2016
Pyridinium and bis-pyridinium aldoximes are used as antidotes to reactivate acetylcholinesterase (AChE) inhibited by organophosphorus nerve agents.
Rachid Baati (1843906), Mélanie Loiodice (2013088), Guillaume Mercey (2013097), Maria Kliachyna (2013094), Julien Renou (2013079), Tristan Verdelet (2013085), Emilie Gillon (447682), Florian Nachon (228914), Mélanie Arboléas (2013091), Ludovic Jean (2013082), Pierre-Yves Renard (1679626)   +10 more
core   +1 more source

Synthesis of bisquaternary nonsymmetric acetylcholinesterase reactivators

, 2010
Stanislav Sopr: PREPARATION OF BISQUARTERNARY NON-SYMETRIC ACETYLCHOLINESTERASE REACTIVATORS Abstract The acetylcholinesterase (AChE) reactivators cause the re-activation of AChE activity after inhibition by organophosphorus compounds (OP).
Sopr, Stanislav
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The therapy of organophosphorus poisoning with particular regard to the application of' reactivators of the inhibited cholinesterase [PDF]

, 1965
Prikazani su osnovni podaci o mehanizmu inhibicije kolinesteraze organofosfornim spojevima kao i o svojstvima inhibiranog enzima. Opširnije je opisan mehanizam reaktivacije inhibirane kolinesteraze, a osobito terapijske mogućnosti koje se danas ...
Katja Wilhelm, Wilhelm, Katja
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Inhibition Potencial of Human Acetylcholinesterase Reactivators in vitro Testing [PDF]

, 2011
Charles University in Prague Faculty of Pharmacy in Hradec Kralove Department of Farmacology and Toxicology Candidate: Mgr. Vendula Šepsová Supervisor: PharmDr. Jana Ţďárová Karasová, PhD. Consultant: PharmDr. Marie Vopršalová, Csc.
Šepsová, Vendula
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Substituted Monoquaternary Oximes as Reactivators of Cyclosarin- and Chlorpyrifos-Inhibited Acetylcholinesterase [PDF]

, 2006
U ovome in vitro istraživanju testiran je reaktivacijski potencijal triju reaktivatora acetilkolinesteraze (AChE; EC 3.1.1.7) dobivenih iz monokvaternog reaktivatora pralidoksima.
Martina Hrabinova, Jun, Daniel, Kamil Kuča, Daniel Jun, Veronika Racakova, Racakova, Veronika, Hrabinova, Martina, Kuča, Kamil   +7 more
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Ionization constants of cholinesterase-reactivating bispyridinium aldoximes

Journal of Pharmacy and Pharmacology, 1967
D, Bieger, O, Wassermann
openaire   +2 more sources

Oxime reactivators and their in vivo and in vitro effects on nicotinic receptors

, 2011
Current treatment of organophosphorus poisoning, resulting in overstimulation and desensitization of muscarinic and nicotinic receptors by acetylcholine (ACh), consists of the administration of atropine and oxime reactivators. However, no versatile oxime
Krusek, J, Tobin, Gunnar,, Killi, Uday Kumar,, Fusek, J, Kuca, K, Jun, D, Soukup, O, Kaniakova, M, Oz, M   +8 more
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Synthesis of novel acetylcholinesterase reactivators of isoquinolinic type [PDF]

, 2017
Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Student: Miroslava Hozová Supervisor: PharmDr. Jaroslav Roh, Ph.D. Consultant: RNDr. Dávid Maliňák, Ph.D.
Hozová, Miroslava
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Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides. [PDF]

J Enzyme Inhib Med Chem, 2022
Kohoutova Z, Malinak D, Andrys R, Svobodova J, Psotka M, Schmidt M, Prchal L, Musilek K.   +7 more
europepmc   +1 more source