Results 141 to 150 of about 4,982 (202)

Ligand and structure-based toxicological assessment of (thio)semicarbazones on cholinesterases. [PDF]

J Comput Aided Mol Des
de Sousa DS, Gomes AOCV, Roberto CHA, Belarmino AB, da Silva Mendes FR, Marinho MM, de Lima-Neto P, Marinho GS.   +7 more
europepmc   +1 more source

Morpholine as a privileged scaffold for neurodegenerative disease therapeutics. [PDF]

RSC Adv
Parmbil SK, Kumar S, Rangarajan TM, Grace Thomas Parambi D, Maliyakkal N, Petzer A, Petzer JP, Mathew B.   +7 more
europepmc   +1 more source

Characterization of the Anticholinesterase and Antioxidant Properties of Phytochemicals from <i>Moringa oleifera</i> as a Potential Treatment for Alzheimer's Disease. [PDF]

Biomedicines
Aljadaan AM, AlSaadi AM, Shaikh IA, Whitby A, Ray A, Kim DH, Carter WG.   +6 more
europepmc   +1 more source

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On the multifunctionality of cholinesterases

Chemico-Biological Interactions, 2005
Here we present novel information on non-classical functions of cholinesterases and on a cross-talk linking the two enzymes AChE and BChE. The first part of the article is focussed on the regulation of ChEs and the effects acquired when one of the proteins is knocked down (siRNA for BChE, AChE knock-out mouse).
P G, Layer, K, Allebrandt, P, Andermann, E, Bodur, R, Boopathy, A H, Bytyqi, L E, Paraoanu   +6 more
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Cholinesterase in the Lens

Archives of Ophthalmology, 1967
Recent reports implicating anticholinesterase agents in the production of lens opacities have led us to look for the target of these agents, that is, the enzyme cholinesterase, in the lens. A form of cholinesterase, sensitive to low concentrations of eserine, has been found.
J, Michon, J H, Kinoshita
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Cholinesterases in Neurofibromas

Archives of Dermatology, 1962
Cholinesterase is an enzyme associated with neural tissue. It has been demonstrated chemically and histochemically in sensory and motor tissue of the central nervous system, the myoneural junction, and the sensory end-organs. 1 Specific cholinesterase, which hydrolyzes acetylcholine and acetylbetamethylcholine (methacholine), is found in autonomic ...
R K, WINKELMANN, L A, JOHNSON
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Cholinesterases and Cholinesterase Inhibitors

Archives of Neurology, 2001
1. Introduction 2. Cholinesterase Inhibitors: An Introduction 3. Molecular Structure of Cholinesterases and Complexes with Inhibitors 4. Rational Design of Cholinesterase Inhibitors 5. Genetics and Epigenetics of Mammalian Cholinesterases 6. The Gene Structure of Cholinesterases 7. Molecular Forms and Anchoring of Cholinesterases 8. Mechanism of Action
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Lithium and cholinesterase

Progress in Neuro-Psychopharmacology, 1980
Abstract 1. 1. Preliminary data show that lithium carbonate administered in patients with endogenous depression significantly inhibits serum cholinesterase. 2. 2. The interaction of lithium with cholinergic system could be envisaged as a possible mechanism of lithium therapeutic action in affective disorders.
S J, Choi, R M, Derman
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Cholinesterase in a Receptor

Science, 1958
Cholinesterase is found at the sites for mechanoelectric conversion of Pacinian corpuscles; its acetylcholine-splitting activity is of the same order of magnitude as that of the cholinesterase at neuromuscular junctions. The enzyme is not a typical acetylcholinesterase.
W R, Loewenstein, D, Molins
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The Cholinesterase Inhibitors

Journal of Psychiatric Practice, 2003
Dementia is a serious and growing problem that presents enormous burdens to patients, their families, and national healthcare systems throughout the world. In the United States, there are currently two classes of psychopharmacologic agents approved for the treatment of Alzheimer's disease: the cholinesterase inhibitors, which are approved for use in ...
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