Results 121 to 130 of about 8,411 (245)

The Dementia Orchestra

Journal of the American Geriatrics Society, EarlyView.
David B. Reuben
wiley   +1 more source

Bioactive Phenolics of Lygeum spartum L.: Insights Into Antioxidant, Anticholinesterase, and Antityrosinase Activities

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Phenolic profile and bioactivity of Lygeum spartum L. ABSTRACT The phenolic composition of roots and leaves of Lygeum spartum L., a Mediterranean Poaceae species, was analyzed by HPLC–DAD, revealing an organ‐specific distribution of phenolic compounds, with ferulic acid identified as the predominant phenolic compound in the methanolic leaf extract (4 ...
Zohra Arabi, Rania Arabi, Dilaycan Çam, Cansel Çakir, Mehmet Öztürk, Hamdi Bendif, Gharieb S. El‐Sayyad, Mohamed A. M. Ali, Walid Elfalleh, Stefania Garzoli   +9 more
wiley   +1 more source

Synthesis, Characterization, and Multifunctional Bioactivity of ZnO/CuO@Amoxicillin Nanocomposites: A Synergistic Nano‐Platform With Potent Antioxidant, Anti‐Inflammatory, Antidiabetic, and Anti‐Cholinesterase Activities

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
ZnO/CuO@amoxicillin nanocomposite, synthesized via sol–gel route, demonstrates exceptional multifunctional performance. It strongly inhibits α‐amylase and α‐glucosidase, effectively suppresses inflammation, and exhibits superior antioxidant activity surpassing ascorbic acid.
Hocine Sadam Nesrat, Abdelatif Aouadi, Ibtissam Laib, Salah Eddine Laouini, Abderrhmane Bouafia, Djamila Hamada Saoud, Halima Zidane, Hafidha Terea, Mahmood M. S. Abdullah, Tomasz Trzepieciński, Dalila Saidane‐Mosbahi   +10 more
wiley   +1 more source

Cholinesterases colocalize with sites of neurofibrillary degeneration in aged and Alzheimer\u27s brains

, 1994
Acetylcholinesterase and butyrylcholinesterase have been associated with structures undergoing neurofibrillary degeneration, as well as with all types of senile plaques, in non-demented aged and Alzheimer\u27s brains.
Mufson, E. J., Gómez-Ramos, P., Morán, M. A.   +2 more
core   +1 more source

First Report on the Phytochemical and Pharmacological Properties of Hedysarum yilmazunalii

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Hedysarum yilmazunalii was collected from Erzincan, Türkiye. The leaf, stem, and root parts were then used for methanolic extraction. The extracts were analyzed for their phytochemical composition by LC–MS/MS and tested for antioxidant, enzyme inhibitory, and antiproliferative activities.
Etem Osma, Tuğçe Varol, Samed Şimşek, Sevgi Altın, Mustafa Abdullah Yılmaz, Ali Aydın, Müjgan Elveren, Ali Kandemir   +7 more
wiley   +1 more source

Dual Transcranial Direct Current Stimulation Modulates Hierarchical Functional Network Organization in Post‐Stroke Cognitive Impairment: A Randomized Controlled Trial

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Bilateral DLPFC dual‐tDCS significantly promotes cognitive recovery by modulating the rs‐fMRI hierarchical organization of functional brain networks, ranging from regional synchrony, distant regions connectivity and global network topological integration.
Yao Wang, Wan Liu, Wenjie Yang, Jun Hu, Xinxin Cheng, Hao Yu, Yin Shi, Li Liu, Jiang Rao, Guangxu Xu   +9 more
wiley   +1 more source

Pragmatic Phenotype–Electrophysiology–Genomics Integration in Pediatric Congenital Myasthenic Syndromes: Insights From 36 Patients in a Single‐Center Study in China

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
In 36 Chinese pediatric CMS patients, integrated phenotype, RNS, and genomic assessment revealed marked genetic heterogeneity across 17 CMS‐associated genes and frequent VUS‐related uncertainty. Genotype‐informed therapy improved MG‐ADL scores, while CHAT‐CMS identified a high‐risk subgroup for early respiratory failure and mortality.
Liya Cui, Kaiyue Ma, Xiaona Fu, Lin Ge, Bingbing Jia, Wenna Ma, Lei Yang, Zhimei Liu, Junlan Lv, Wenmiao Xu, Lijuan Wang, Guangyuan Zhao, Jiuwei Li, Jie Wu, Quan Wang, Changhong Ding, Xiaotun Ren, Xinming Shen, Hui Xiong   +18 more
wiley   +1 more source

Advances in Targeting Central Cholinergic Dysfunction for Neurodegenerative Diseases: From Pharmacotherapy to Neuromodulation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This review charts the evolution of cholinergic therapies for neurodegenerative diseases—from classical acetylcholinesterase inhibitors (AChEIs) providing symptomatic relief to precision multi‐target drugs and neuromodulation (VNS, DBS, NIBS) that restore dysfunctional circuits. Emerging gene therapy, cell regeneration, and advanced cholinergic imaging
Lei Lei, Xiaoyu Hu, Ruida Lu, Jian‐jun Yang, Qingsheng Meng   +4 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Benzimidazol‐2‐One Hybrids as Potential Anti‐Alzheimer's Disease Agents

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder for which single‐target therapies often provide insufficient benefit, motivating the development of multi‐target‐directed ligands (MTDLs). In this study, a novel series of benzimidazolone‐based hybrids incorporating piperazine, coumarin, and triazole moieties was designed,
Fatih Yılmaz, Emre Menteşe, Ozan Emre Eyüpoğlu, Bahittin Kahveci, Mustafa Emirik   +4 more
wiley   +1 more source

Therapeutic Potential of Chickpea‐Derived Bioactives: A Review With Perspective of Different In Vitro, Animal, and Human Studies

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Chickpea (Cicer arietinum L.) is an important dietary legume worldwide and provides micronutrients and phytochemicals, including phenolics, flavonoids, carotenoids, bioactive peptides, dietary fiber, and resistant starch. This narrative review summarizes evidence from in vitro, animal, and human studies on the potential health relevance of ...
Rohama Shahid, Maria Maqsood, Nimrah Ashraf, Farzeen Asghar, Nauman Khalid   +4 more
wiley   +1 more source