Results 121 to 130 of about 12,810 (265)

Native PLGA nanoparticles attenuate disease pathology via multiple pathways in 5xFAD Alzheimer's model

open access: yesAlzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Elevated amyloid beta (Aβ) levels and aggregation contribute to neurotoxicity and development of Alzheimer's disease (AD), the leading cause of dementia in the elderly. While we reported that native poly(D,L‐lactic‐co‐glycolic acid) (PLGA) nanoparticles, clinically used in drug delivery, suppress Aβ aggregation/toxicity, their ...
Govindarajan Karthivashan   +8 more
wiley   +1 more source

Comparative Insights Into Detoxification, Regulation, and Evolution of Neonicotinoid Resistance in Three Planthoppers

open access: yesArchives of Insect Biochemistry and Physiology, Volume 122, Issue 1, May 2026.
Integrated neonicotinoid resistance mechanism in planthoppers. ABSTRACT Planthoppers, the brown planthopper (BPH, Nilaparvata lugens), white‐backed planthopper (WBPH, Sogatella furcifera), and small BPH (SBPH, Laodelphax striatellus) are among the most destructive rice pests in Asia.
Minyoung Choi, Murtaza Khan, Juil Kim
wiley   +1 more source

Aerospace Medicine and Biology: A continuing bibliography, supplement 191 [PDF]

open access: yes
A bibliographical list of 182 reports, articles, and other documents introduced into the NASA scientific and technical information system in February 1979 is ...

core   +1 more source

Prevalence and impact of prescribing cascades in community‐dwelling adults: Longitudinal analysis of the Irish longitudinal study on ageing (TILDA)

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1500-1508, May 2026.
Prescribing cascades occur when medication is prescribed to prevent/treat the adverse effects of another medication and may be intentional/unintentional. This study examines the prevalence of nine prescribing cascades (ThinkCascades) in The Irish Longitudinal StuDy on Ageing (TILDA).
Ann Sinéad Doherty   +7 more
wiley   +1 more source

Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish

open access: yesChemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
Cléia Rocha de Sousa Feitosa   +17 more
wiley   +1 more source

Contemporary Applications of Chemical Libraries for Drug Discovery and Methods for Their Synthesis

open access: yesChemistryEurope, Volume 4, Issue 5, May 2026.
Screening of chemical libraries has over the past decades become a cornerstone of drug discovery. Today, a broad range of chemical libraries exist but they are often not well described in terms of diversity. This review describes current efforts which aim to visualize chemical diversity in compound collections and discuss current trends in synthetic ...
Tobias N. Hansen, Nils J. V. Hansen
wiley   +1 more source

Correspondence of Basal Forebrain Resting‐State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Altered functional connectivity of basal forebrain subregions (Ch1‐3, Ch4) and widespread cerebral hypometabolism were identified in Alzheimer's disease using simultaneous PET/MRI. Spatial correspondence with normative neurotransmitter receptor and transporter maps suggested that serotonergic and dopaminergic systems may contribute to AD‐related ...
Yujie He   +11 more
wiley   +1 more source

Usporedba protokola za mjerenje aktivnosti kolinesteraza u ljudskoj krvi Ellmanovom metodom [PDF]

open access: yes, 2000
This paper presents a protocol for routine assays of human blood cholinesterase activities which separates erythrocytes from plasma by centrifugation and measures acetylcholinesterase activity in unwashed erythrocytes and butyrylcholinesterase activity ...
Elsa Reiner   +3 more
core  

Sugammadex Vs. Neostigmine for Cerebral Perfusion During Emergence From General Anesthesia in Patients Undergoing Carotid Endarterectomy: A Double‐Blind Randomized Controlled Trial

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
In this double‐blind RCT involving 82 patients undergoing carotid endarterectomy, sugammadex significantly reduced excessive cerebral blood flow during emergence from general anesthesia compared to neostigmine (MCAV% S: 24,600 vs. 31,575, p = 0.044). Sugammadex also shortened extubation time (110 vs.
Xuefei Jia   +19 more
wiley   +1 more source

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