Results 111 to 120 of about 12,810 (265)
Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Kaempferol has been shown to be beneficial in the treatment of Alzheimer's disease (AD) in animal models. However, the action mechanism remains unclear. AKR1B1 has been identified as a target of kaempferol, initially suggested by the Therapeutic Target Database, DrugBank, and PubChem, and subsequently confirmed through experimental validation.
Le Li +5 more
wiley +1 more source
The inotropic effects of quinidine and procaine amide : an experimental study [PDF]
, 1959 Thesis (M.D.)--Boston ...
Hastings, Elliot P.
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Journal of the Peripheral Nervous System, Volume 31, Issue 2, June 2026.ABSTRACT Diabetic peripheral neuropathy (DPN) is a prevalent and disabling complication of diabetes, yet whether established clinical DPN is reversible remains debated. At the 35th Annual Meeting of NEUROdiab, a formal debate examined arguments ‘for’ and ‘against’ the proposition that clinical DPN can be reversed.
Gordon Sloan +9 more
wiley +1 more source
Effect of pH on Blepharisma intermedium. 5. Studies on esterases [PDF]
, 1977 Synopsis. Esterases of Blepharisma intermedium grown in buffered media of different pH values and in unbuffered media have been characterized. Selective inhibition studies indicate six carboxylesterases, two arylesterases and one cholinesterase in all ...
Jyothy, P.S., Shadaksharaswamy, M.
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Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira +9 more
wiley +1 more source
Organophosphorus (OP) compounds include a broad group of toxic chemicals such as insecticides, chemical warfare agents and antiwear agents. The liver cytochromes P450 bioactivate many OPs to potent inhibitors of serine hydrolases.
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ChemMedChem, Volume 21, Issue 10, 27 May 2026.Novel coumarin‐rasagiline hybrid molecules were designed and synthesized as multifunctional agents targeting key pathological mechanisms of neurodegenerative diseases. These compounds exhibited hMAO‐B inhibitory activity, antioxidant and neuroprotective effects, supported by ADMET profiling and molecular modeling studies. The design of hybrid molecules
Aitor Carneiro +8 more
wiley +1 more source
Advanced Science, Volume 13, Issue 27, 13 May 2026.This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang +21 more
wiley +1 more source
Phylogeny of putative cholinergic visual pathways through the pretectum to the hypothalamus in teleost fish [PDF]
, 1990 Meyer, Dietrich L., Wullimann, Mario F.
core +1 more source