Results 101 to 110 of about 12,810 (265)

Structure Related Inhibition of Enzyme Systems in Cholinesterases and BACE1 In Vitro by Naturally Occurring Naphthopyrone and Its Glycosides Isolated from Cassia obtusifolia

Molecules, 2017
Cassia obtusifolia Linn. have been used to improve vision, inflammatory diseases, and as hepatoprotective agents and to promote urination from ancient times.
Srijan Shrestha, Su Hui Seong, Pradeep Paudel, Hyun Ah Jung, Jae Sue Choi   +4 more
doaj   +1 more source

The Association Between Hospital Harms and 1‐Year Mortality Following a Hip Fracture in Ontario, Canada: A Cohort Study

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background Hip fractures are a significant public health concern, associated with substantial morbidity and mortality. Mortality is the most serious consequence of hip fractures, with a 1‐year rate ranging from 14% to 36%. Hospital harms are also more prevalent among older adults with hip fractures, further increasing their risk of mortality ...
Anum Ali, Arrani Senthinathan, Laleh Rashidian, Yu Qing Bai, Walter P. Wodchis, Susan E. Bronskill, Chantal Backman, Kednapa Thavorn, Kerry Kuluski, Sara J. T. Guilcher   +9 more
wiley   +1 more source

Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges

Molecules
The main feature of neurodegenerative diseases, including Alzheimer’s disease, is the network of complex and not fully recognized neuronal pathways and targets involved in their onset and progression.
Rebecca Orioli, Federica Belluti, Silvia Gobbi, Angela Rampa, Alessandra Bisi   +4 more
doaj   +1 more source

Anti-Alzheimer’s Studies on β-Sitosterol Isolated from Polygonum hydropiper L.

Frontiers in Pharmacology, 2017
The family Polygonaceae is known for its traditional use in the management of various neurological disorders including Alzheimer’s disease (AD). In search of new anti-AD drugs, β-sitosterol isolated from Polygonum hydropiper was subjected to in vitro, in
Muhammad Ayaz, Muhammad Junaid, Farhat Ullah, Fazal Subhan, Abdul Sadiq, Gowhar Ali, Muhammad Ovais, Muhammad Shahid, Muhammad Shahid, Ashfaq Ahmad, Ashfaq Ahmad, Abdul Wadood, Mohamed El-Shazly, Nisar Ahmad, Sajjad Ahmad   +14 more
doaj   +1 more source

Assessment of enzyme inhibition : a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs [PDF]

, 2017
Both authors are grateful for the collaborations on multi-target drugs facilitated by COST Action CM1103 (2011-2015).The actions of many drugs involve enzyme inhibition.
Ramsay, Rona R., Tipton, Keith F.
core   +1 more source

Evaluation of Enzyme Inhibition and Kinetic Profiles of Origanum Essential Oils on Metabolic and Central Nervous System Targets

Natural Sciences, Volume 6, Issue 3, July 2026.
The essential oils of three Origanum species were chemically characterized and evaluated for their antioxidant and enzyme inhibitory activities. The different compositions confer selective bioactivities: O. vulgare exhibits good antioxidant and α‐glucosidase inhibitory activity, O. majorana shows promising tyrosinase inhibition, and O.
Giuseppe Amato, Lucia Caputo, Laura De Martino, Daniela Grulova, Barbara Borczak, Joanna Kapusta‐Duch, Vincenzo De Feo   +6 more
wiley   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, Volume 63, Issue 6, Page 1509-1545, June 2026.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Macroalgae as a Valuable Source of Naturally Occurring Bioactive Compounds for the Treatment of Alzheimer’s Disease

Marine Drugs, 2019
Alzheimer’s disease (AD) is a neurological condition that affects mostly aged individuals. Evidence suggests that pathological mechanisms involved in the development of AD are associated with cholinergic deficit, glutamate excitotoxicity, beta ...
Tosin A. Olasehinde, Ademola O. Olaniran, Anthony I. Okoh   +2 more
doaj   +1 more source

The importance of longitudinal evaluation using DAT‐SPECT in organophosphate‐induced toxic parkinsonism

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
We performed longitudinal evaluation using magnetic resonance imaging (MRI) and dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) in a case of organophosphate‐induced toxic parkinsonism. Fluid‐attenuated inversion recovery (FLAIR) images showed bilateral striatal hyperintensity in the acute phase, followed by reduction of ...
Shuhei Nakao, Yoichiro Kogoh, Hideki Funahashi, Yusei Yanoma, Minako Azuma, Yasushi Ishida, Yoji Hirano   +6 more
wiley   +1 more source

Theta burst stimulation for depressive symptoms in early‐stage dementia with Lewy bodies: Protocol for a single‐arm open‐label feasibility study (DL‐TBS Study)

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 2, June 2026.
Abstract Background Depressive symptoms are highly prevalent in early‐stage dementia with Lewy bodies (DLB) and are associated with impaired quality of life, functional decline, and increased caregiver burden. However, effective and well‐tolerated treatment options for depression in this population remain limited because of marked drug sensitivity and ...
Shun Takahashi, Yuto Satake, Masahiro Hata, Hisaki Omori, Koichi Hosomi, Manabu Ikeda   +5 more
wiley   +1 more source