Results 101 to 110 of about 8,411 (245)

Naturally Inspired Coumarin Derivatives in Alzheimer’s Disease Drug Discovery: Latest Advances and Current Challenges

Molecules
The main feature of neurodegenerative diseases, including Alzheimer’s disease, is the network of complex and not fully recognized neuronal pathways and targets involved in their onset and progression.
Rebecca Orioli, Federica Belluti, Silvia Gobbi, Angela Rampa, Alessandra Bisi   +4 more
doaj   +1 more source

Anti-Alzheimer’s Studies on β-Sitosterol Isolated from Polygonum hydropiper L.

Frontiers in Pharmacology, 2017
The family Polygonaceae is known for its traditional use in the management of various neurological disorders including Alzheimer’s disease (AD). In search of new anti-AD drugs, β-sitosterol isolated from Polygonum hydropiper was subjected to in vitro, in
Muhammad Ayaz, Muhammad Junaid, Farhat Ullah, Fazal Subhan, Abdul Sadiq, Gowhar Ali, Muhammad Ovais, Muhammad Shahid, Muhammad Shahid, Ashfaq Ahmad, Ashfaq Ahmad, Abdul Wadood, Mohamed El-Shazly, Nisar Ahmad, Sajjad Ahmad   +14 more
doaj   +1 more source

Colocalization of cholinesterases with β amyloid protein in aged and Alzheimer\u27s brains

, 1993
The colocalization of β amyloid protein with the enzymes acetyl- and butyrylcholinesterase was assessed using immunocytochemistry for β amyloid protein and a sensitive histochemical technique for cholinesterases.
Mufson, E. J., Gómez-Ramos, P., Morán, M. A.   +2 more
core   +1 more source

A Motor Vehicle Crash as an Early Signal of Alzheimer's Disease and Related Dementias

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Background People with Alzheimer's disease and related dementias (ADRD) are at increased risk of motor vehicle crash (MVC) due to cognitive decline, which often begins years before diagnosis. MVC could serve as an indicator of ADRD‐related cognitive impairment and facilitate earlier diagnosis.
Nina R. Joyce, Steven Balog, Rachel Gaither, Melissa R. Pfeiffer, Fiona Bhondoekhan, Brian R. Ott, Seth A. Margolis, Alison E. Curry, Andrew R. Zullo   +8 more
wiley   +1 more source

Macroalgae as a Valuable Source of Naturally Occurring Bioactive Compounds for the Treatment of Alzheimer’s Disease

Marine Drugs, 2019
Alzheimer’s disease (AD) is a neurological condition that affects mostly aged individuals. Evidence suggests that pathological mechanisms involved in the development of AD are associated with cholinergic deficit, glutamate excitotoxicity, beta ...
Tosin A. Olasehinde, Ademola O. Olaniran, Anthony I. Okoh   +2 more
doaj   +1 more source

Virtual Screening Approaches to Identify Promising Multitarget-Directed Ligands for the Treatment of Autism Spectrum Disorder

Molecules
Autism spectrum disorder is a complex neurodevelopmental disorder. The available medical treatment options for autism spectrum disorder are very limited.
Jakub Jończyk, Klaudia Przybylska, Marek Staszewski, Justyna Godyń, Tobias Werner, Monika Stefaniak-Napieralska, Holger Stark, Krzysztof Walczyński, Marek Bajda   +8 more
doaj   +1 more source

Disseminated Klebsiella pneumoniae Infection Mimicking Multiple Colonic Subepithelial Lesions: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT We report a rare case of disseminated Klebsiella pneumoniae infection mimicking multiple subepithelial lesion (SEL)‐like elevations throughout the colon. A 73‐year‐old man was referred for the treatment of diarrhea, edema, and anemia. Colonoscopy revealed numerous SEL‐like elevations from the cecum to the rectum, raising suspicion for ...
Yoshiaki Kobayashi, Tadanobu Nagaya, Mai Iwaya, Hiroshi Ikeuchi, Takuma Okamura, Takeshi Uehara, Yugo Iwaya   +6 more
wiley   +1 more source

Design, Synthesis and Molecular Docking Studies of Some Novel Hydrazone Derivatives Based on Trimetazidine as Selective and Potent AChE Inhibitors

Drug Development Research, Volume 87, Issue 7, November 2026.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disease, and cholinergic dysfunction is considered one of the fundamental pathological factors of this disease. Guided by the clinically used acetylcholinesterase (AChE) inhibitor donepezil, we explored trimetazidine dihydrochloride as an accessible starting scaffold to generate ...
Muhammed Oğuzhan Doğan, Begüm Nurpelin Sağlık Özkan, Abdullah Burak Karaduman, Sevgi Karakuş, Yusuf Özkay, Zafer Asım Kaplancıklı, Fatih Tok   +6 more
wiley   +1 more source

Phylogeny of putative cholinergic visual pathways through the pretectum to the hypothalamus in teleost fish [PDF]

, 1990
Wullimann, M., Meyer, Dietrich L., Wullimann, Mario F., Meyer, D.   +3 more
core   +2 more sources

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source