Inter-dependent Tissue Growth and Turing Patterning in a Model for Long Bone Development [PDF]
The development of long bones requires a sophisticated spatial organization of cellular signaling, proliferation, and differentiation programs. How such spatial organization emerges on the growing long bone domain is still unresolved. Based on the reported biochemical interactions we developed a regulatory model for the core signaling factors IHH ...
arxiv +1 more source
Unsupervised hyperspectral data mining and bioimaging by information entropy and self-modeling curve resolution [PDF]
Unsupervised estimation of the dimensionality of hyperspectral microspectroscopy datasets containing pure and mixed spectral features, and extraction of their representative endmember spectra, remains a challenge in biochemical data mining. We report a new versatile algorithm building on semi-nonnegativity constrained self-modeling curve resolution and
arxiv
Anatomy, morphology and evolution of the patella in squamate lizards and tuatara (Sphenodon punctatus) [PDF]
The patella (kneecap) is the largest and best-known of the sesamoid bones, postulated to confer biomechanical advantages including increasing joint leverage and reinforcing the tendon against compression.
Benjamin M+18 more
core +2 more sources
Exosomes can reduce tissue damage in temporomandibular joint osteoarthritis (TMJOA), but rapid clearance limits their efficacy. This study encapsulates exosomes in hyaluronic acid hydrogels for controlled release. In a rat model, hydrogel‐encapsulated exosomes outperform free exosomes in preserving bone integrity and reducing tissue destruction ...
Victor Diez‐Guardia+7 more
wiley +1 more source
Recent progress in cartilage lubrication [PDF]
Healthy articular cartilage, covering the ends of bones in major joints such as hips and knees, presents the most efficiently-lubricated surface known in nature, with friction coefficients as low as 0.001 up to physiologically high pressures. Such low friction is indeed essential for its well being.
arxiv
Response of human engineered cartilage based on articular or nasal chondrocytes to interleukin-1? and low oxygen [PDF]
Previous studies showed that human nasal chondrocytes (HNC) exhibit higher proliferation and chondrogenic capacity as compared to human articular chondrocytes (HAC).
Andrea Barbero+8 more
core +1 more source
Chondrocytes and their matrix [PDF]
Biology of Cartilage Cells. By R.A. Stockwell. Pp.329. (Cambridge University Press: London, New York and Melbourne, 1979.) £25.
openaire +1 more source
Pyrophosphate‐Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality
The role of calcium pyrophosphate (Ca‐PP) in heterotopic bone formation and material degradation is investigated using calcium phosphate (CaP) compositions with varying Ca‐PP content. Results show that Ca‐PP does not impede heterotopic bone formation, minimally affects CaP degradation at non‐osseous sites, and increases phagocytosis.
Martina Jolic+7 more
wiley +1 more source
Are Paralysed Chondrocytes Really Dying? [PDF]
The aims of the current study were to establish a system of culture for induction of paralysed chondrocytes and to investigate if these cells are really dying. Chondrocytes were isolated from the growth cartilage of fetal equines, centrifuged and cultured as pellets in either 10% fetal calf serum or 10% horse serum for 28 days and processed for light ...
arxiv
Time-of-flight secondary ion mass spectrometry-based molecular distribution distinguishing healthy and osteoarthritic human cartilage [PDF]
Osteoarthritis (OA) is a pathology that ultimately causes joint destruction. The cartilage is one of the principal affected tissues. Alterations in the lipid mediators and an imbalance in the metabolism of cells that form the cartilage (chondrocytes) have been described as contributors to the OA development.
arxiv +1 more source